Chicken coccidiosis attenuated live vaccine as well as preparation method and application thereof

A chicken coccidiosis and vaccine technology, which is applied in the direction of medical formulas, medical preparations containing active ingredients, antibody medical ingredients, etc., can solve the problems of slow growth and poor weight gain of chickens

Pending Publication Date: 2018-09-21
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a chicken coccidiosis attenuated live vaccine and its preparation me...

Method used

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  • Chicken coccidiosis attenuated live vaccine as well as preparation method and application thereof
  • Chicken coccidiosis attenuated live vaccine as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of Chicken Coccidiosis Attenuated Live Vaccine

[0023] Count the sporulated oocysts of Eimeria brucei and Eimeria placidum respectively with a hemocytometer to obtain their concentrations, and calculate the required quantity of each component of the coccidia oocysts according to the ratio in Table 1. Put them into different clean containers, add the preservation solution and stir to obtain the mixed oocyst solution of the corresponding components, and store them in an environment of 2-8°C for later use.

[0024] Table 1 Composition of chicken coccidiosis attenuated live vaccine

[0025]

Embodiment 2

[0027] Take 110 SPF chickens aged 3 to 7 days (referring to chickens grown in barrier systems or isolators without the pathogens of major chicken infectious diseases that are popular internationally, especially domestically), and divide them into 11 groups, with 10 chickens in each group, and weigh them. Among them, the 1st and 2nd groups are the immune challenge groups of the vaccine described in the ratio 1, the 3rd and 4th groups are the immune challenge groups of the vaccine described in the ratio 2, and the 5th and 6th groups are the vaccines described in the ratio 3 The 7th and 8th groups are immune challenge groups of the vaccine described in ratio 4, the 9th and 10th groups are non-immune challenge groups; the 11th group is non-immune and non-worm challenge groups.

[0028] The 11 groups of SPF chickens were isolated and reared under the same conditions. After oral administration for 21 days, the chickens in each group were weighed and challenged with worms. Insect poi...

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PUM

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Abstract

The invention discloses chicken coccidiosis attenuated live vaccine as well as a preparation method and application thereof. The vaccine contains 100 to 500/sera of Eimeria brunetti and 100 to 500/sera of Eimeria. The vaccine is prepared by uniformly mixing early-maturing attenuated strains of the Eimeria brunetti and early-maturing attenuated strains of the Eimeria, and storing the mixed strainsin storage liquid. The vaccine composition is scientific and reasonable; the cost is low; after the use, no drug residue exists; no drug tolerance is generated; the environment pollution cannot be caused; the immunogenicity is good; the use is safe; the vaccine can be applied to preparation of medicine preparations for preventing chicken coccidiosis.

Description

technical field [0001] The invention relates to the coccidiosis vaccine and its application field, in particular to a chicken coccidiosis attenuated live vaccine and its preparation method and application. Background technique [0002] Chicken coccidiosis is an epidemic disease characterized by enteritis, diarrhea, growth retardation, decreased feed conversion rate and death caused by one or more Eimeria coccidiosis parasitizing on chicken intestinal mucosal epithelial cells. Among the 7 species of Eimeria recognized in the world, Eimeria brucei belongs to the species with moderate pathogenicity, and Eimeria placidus is the species with relatively weak pathogenicity. From the investigation of the prevalence status, it can be seen that 7 kinds of coccidia were found in a large area, but there were great differences in the prevalence rates of various coccidia. Eimeria brucei can be found all over the world, but the reports on the prevalence rate are not the same in different ...

Claims

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Application Information

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IPC IPC(8): A61K39/00A61P33/02
CPCA61K39/00A61K2039/54A61K2039/542A61P33/02A61K2300/00
Inventor 谭志坚翁亚彪刘丽丹王文莉伍存唐建红曾莉
Owner FOSHAN STANDARD BIO TECH
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