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Method for rapidly detecting contents of ginsenosides in red ginseng alcohol extraction solution and application

A technology of ginsenoside and alcohol extract, which is applied in measuring devices, color/spectral characteristic measurement, instruments, etc. It can solve the problems of high professional level requirements for analysts, inapplicable production process control, long analysis time analysis equipment, etc. , to shorten the measurement time, solve the problem of ginsenoside content monitoring, and simple operation

Inactive Publication Date: 2018-09-21
DALI PHARMA
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although this method has high analytical precision, it requires a long analysis time and sophisticated analytical equipment, and requires a high level of professionalism for analysts, so it is not suitable for production process control.

Method used

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  • Method for rapidly detecting contents of ginsenosides in red ginseng alcohol extraction solution and application
  • Method for rapidly detecting contents of ginsenosides in red ginseng alcohol extraction solution and application
  • Method for rapidly detecting contents of ginsenosides in red ginseng alcohol extraction solution and application

Examples

Experimental program
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Effect test

Embodiment 1

[0042] A method for rapidly detecting ginsenoside content in red ginseng alcohol extract, said ginsenoside being ginsenoside Rg 1 , Re, Rf, Rb 1 , Rc, Rb 2 and Rd, the method comprises the steps of:

[0043] 1. Collection of Calibration Set Samples

[0044] Accurately weigh 30g of red ginseng decoction pieces, place them in a glass jacketed extraction tank, add alcohol solution as the extraction solvent, heat and reflux for extraction for a period of time, collect the filtrate, repeat the above steps, a total of 6 times of reflux extraction for one decoction slice, different batches of red ginseng The ethanol dosage, alcohol concentration and single extraction time of ginseng ethanol reflux extraction process were all different. The extracts were collected from time to time during the extraction process of 17 batches as calibration set samples, and a total of 26 calibration set samples were obtained.

[0045] 2. Determination of Reference Values ​​of Calibration Set Sample...

Embodiment 2

[0071] According to the method of Example 1, the difference is that the calculation software BWIQ is used instead, and the quantitative correction model of ginsenosides in the red ginseng alcohol extract is established by using the principal component regression method.

[0072] 1. Use the same calibration set sample as in Example 1, its reference value, and ultraviolet absorption spectrum.

[0073] 2. Establishment of calibration model

[0074] Use BWIQ TM The software (B&W Tek Opto-Electronics, USA) processed the raw data to obtain the characteristic spectrum information of the red ginseng alcohol extract. The comparison of the model performance obtained by multiple preprocessing methods proves that the calibration model with a correlation coefficient greater than 0.95 can be established after the SG smoothed spectrum, without additional complex spectral preprocessing. The quantitative regression model of ginsenosides was established by principal component regression PCR m...

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Abstract

The invention discloses a method for rapidly detecting the contents of seven ginsenosides in a red ginseng alcohol extraction solution and application thereof, and belongs to the field of quality monitoring in the traditional Chinese medicine production process. The method includes the steps of (1), collecting a calibration set sample; (2), determining the ginsenoside reference values of the calibration set sample, wherein the contents of seven ginsenosides Rg1, Re, Rf, Rb1, Rc, Rb2 and Rd in the calibration set sample are determined respectively; (3), determining the ultraviolet absorption spectrum of the calibration set sample; (4), establishing a calibration model; (5), verifying the calibration model; (6), calculating the contents of ginsenosides in the red ginseng alcohol extraction solution to be detected. The method is easy and fast to operate, and compared with the high-performance liquid chromatography, the method shortens the total determination time by 50 times or above. A good correlation exists between the ultraviolet characteristic spectrum and the contents of seven ginsenosides, and quality indexes are monitored in real time to guarantee the completing quality of theextraction process so as to guarantee the final product quality.

Description

technical field [0001] The invention relates to the field of quality monitoring in the production process of traditional Chinese medicines, in particular to a method for rapidly detecting the content of ginsenosides in red ginseng alcohol extracts and its method for determining the content of ginsenosides in the intermediates of red ginseng alcohol extraction units during the production process of Shenmai injection Applications. Background technique [0002] Shenmai injection is a pure Chinese medicine quick-acting preparation developed on the basis of the ancient Chinese medicine "Shengmaisan". Clinically, Shenmai Injection is mainly used for the treatment of cardiovascular diseases such as heart failure and arrhythmia, and is also commonly used as an adjuvant drug for antineoplastic drugs. With the wide application of Shenmai injection, people pay more and more attention to the quality control level of its production process. [0003] A large number of studies have shown...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N21/33
CPCG01N21/33G01N30/02
Inventor 瞿海斌袁玮赵芳张金华李文龙厉明段锦云
Owner DALI PHARMA
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