Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Bortezomib purification method

A technology of bortezomib and purification method, which is applied in the fields of chemical instruments and methods, compounds containing elements of group 3/13 of the periodic table, organic chemistry, etc., can solve the problems of bortezomib with many impurities and reduce production costs, Good dissolution speed, saving manpower and material resources

Inactive Publication Date: 2018-09-25
JIANGSU HANSOH PHARMA CO LTD
View PDF7 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] There are many impurities in the finished product of bortezomib obtained by the above synthetic route, and it is necessary to develop a purification method that can reduce impurities in the finished product of bortezomib and improve product quality

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bortezomib purification method
  • Bortezomib purification method
  • Bortezomib purification method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Add a certain amount of crude bortezomib to an appropriate amount of ethyl acetate and heat to 60-65°C to dissolve, and prepare four solutions with concentrations of 300mg / mL, 90mg / mL, 60mg / mL and 30mg / mL respectively, and cool to 25°C Stand still for crystallization for 22 hours, filter to obtain the finished product of bortezomib, take a small amount for liquid phase detection of purity, and weigh the remaining sample after vacuum drying at 30-40°C to calculate the yield.

[0027] serial number

Embodiment 2

[0029] Add a certain amount of crude bortezomib to an appropriate amount of ethyl acetate and heat to 60-65°C to dissolve, and prepare a crystallization solution with a concentration of 60mg / mL, and select 40°C, 30°C, 20°C, 10°C and 0°C respectively Four different crystallization temperatures, static crystallization for 22 hours, filtered to obtain the finished product of bortezomib, a small amount was used for liquid phase detection of purity, and the remaining samples were vacuum-dried at 30-40°C and weighed to calculate the yield.

[0030] serial number

Embodiment 3

[0032] A certain amount of crude bortezomib was added to an appropriate amount of ethyl acetate and heated to 60-65°C to dissolve to prepare a crystallization solution with a concentration of 60mg / mL, and cooled to 20-30°C to stand for crystallization, and to investigate different crystallization times Effect of Team Bortezomib Yield.

[0033] serial number

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
concentrationaaaaaaaaaa
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention relates to a bortezomib purification method. The bortezomib is recrystallized in ethyl acetate to prepare bortezomib at a high purity. According to the method, bortezomib production efficiency is improved, production cost is lowered, and the bortezomib purification method is suitable for mass production.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a method for crystallization and purification of bortezomib. Background technique [0002] Bortezomib, whose trade name is Velcade, is a new type of antineoplastic drug developed by Millennium Pharmaceutical Company of the United States. The drug is a 26S proteasome inhibitor, which can lead to tumor cell death by blocking the degradation of various proteins that regulate apoptosis and signal transduction in cells. A large number of studies have found that bortezomib is effective in a variety of tumors, especially multiple myeloma, mantle cell lymphoma and other B cell lymphomas (diffuse large B cell type, follicular cell type, small lymphocyte type, etc.) type / chronic lymphocytic leukemia, marginal zone lymphoma), Hodgkin's lymphoma have strong anti-tumor activity. [0003] CN1960996A discloses N-(2-pyrazine carbonyl)-L-phenylalanine and (1S, 2S, 3R, 5S)-pinanediol 1-ammoniu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/02
CPCC07F5/025
Inventor 周明杨文彬葛广存
Owner JIANGSU HANSOH PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com