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Chiral organic metallic framework hollow nanosphere and preparation method and application thereof

An organometallic, hollow nanotechnology, applied in organic chemistry methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of high-efficiency adsorption and separation of racemic amino acids, such as the lack of technical literature, and achieve excellent separation effect, processing Simple, easy-to-use effects

Active Publication Date: 2018-09-28
INST OF CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are few technical literatures on the chiral modification of ZIF-8 at the molecular level and the regulation of the nanostructure of ZIF-8 to efficiently adsorb and separate racemic amino acids.

Method used

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  • Chiral organic metallic framework hollow nanosphere and preparation method and application thereof
  • Chiral organic metallic framework hollow nanosphere and preparation method and application thereof
  • Chiral organic metallic framework hollow nanosphere and preparation method and application thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0047] Example 1. Preparation of Chiral Organometallic Framework Hollow Nanospheres

[0048] The composition of raw materials is as follows:

[0049] 45 parts of styrene

[0050] 3 parts methyl methacrylate

[0051] 2 parts acrylic

[0052] Zinc nitrate 25 parts

[0053] 22 parts of 2-methylimidazole

[0054] D-histidine 3 parts.

[0055] The preparation method is as follows:

[0056] 1. Add 3 parts by mass of methyl methacrylate and 2 parts by mass of acrylic acid to 45 parts by mass of styrene, and react at 80°C for 12 hours under nitrogen protection, using 0.1 part by mass of ammonium persulfate as an initiator. After the reaction was completed, it was centrifuged and freeze-dried for later use.

[0057]2. Dissolve 25 parts by mass of zinc nitrate, 22 parts by mass of 2-methylimidazole, and 3 parts by mass of D-histidine in an appropriate amount of distilled water, and then add the carboxylated polystyrene microspheres obtained in step 1. After hydrothermal reaction...

Embodiment 2

[0065] Example 2. Preparation of Chiral Organometallic Framework Hollow Nanospheres

[0066] The composition of raw materials is as follows:

[0067] 43 parts of styrene

[0068] 4 parts methyl methacrylate

[0069] 2 parts acrylic

[0070] Zinc nitrate 26 parts

[0071] 22 parts of 2-methylimidazole

[0072] D-histidine 3 parts.

[0073] The preparation method is as follows:

[0074] The preparation method that the present invention applies:

[0075] 1. Add 4 parts by weight of methyl methacrylate and 2 parts by weight of acrylic acid to 43 parts by weight of styrene, and react at 80° C. for 12 hours under nitrogen protection, using 0.1 parts by weight of ammonium persulfate as an initiator. After the reaction was completed, it was centrifuged and freeze-dried for later use.

[0076] 2. Dissolve 26 parts by weight of zinc nitrate, 22 parts by weight of 2-methylimidazole, and 3 parts by weight of D-histidine in an appropriate amount of distilled water, and then add the...

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Abstract

The invention discloses a chiral organic metallic framework hollow nanosphere and a preparation method and an application thereof. The chiral organic metallic framework hollow nanosphere comprises thefollowing raw materials in parts by mass: 43-45 parts of styrene, 3-4 parts of methyl methacrylate, 2-3 parts of acrylic acid, 20-26 parts of zinc nitrate, 22-25 parts of 2-methylimidazole, and 3-5 parts of D-histidine. By using a hydro-thermal reaction, the chiral organic metallic framework hollow nanosphere can be obtained in a simple mode. The raw materials are common and easily available; theracemic amino acid splitting performance is excellent, and the separating process is simple.

Description

technical field [0001] The invention relates to a chiral organometallic skeleton hollow nanosphere and a preparation method and application thereof. Background technique [0002] The resolution of racemic amino acids is a specific application of chiral resolution techniques. Amino acids are the basic building blocks of proteins and are widely used in medicine, food and other industries. Amino acid molecules contain chiral centers, and there are D and L enantiomers. The physiological effects of these two isomers are different or completely opposite in most cases. Most of the artificially synthesized amino acids are racemates. In order to meet the requirements of use, chiral resolution is necessary. Amino acid monomers with high optical purity have always been important chemical raw materials for related companies. In the important pharmaceutical industry, the optical purity of amino acid raw materials is even higher. [0003] The chemical resolution method is one of the e...

Claims

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Application Information

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IPC IPC(8): C08F212/08C08F220/14C08F220/06C08F8/32C08G83/00C07C227/40C07C229/24C07C229/26
CPCC07B2200/07C07C227/40C08F8/32C08F212/08C08G83/008C07C229/24C07C229/26C08F220/14C08F220/06
Inventor 宋卫国王小实曹昌燕
Owner INST OF CHEM CHINESE ACAD OF SCI
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