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Azithromycin dispersible tablet

A technology of azithromycin and dispersible tablets, which is applied in the field of azithromycin dispersible tablets, can solve the problems of patients’ blood drug concentration not being optimal, high content of azithromycin single product, and low bioavailability, so as to reduce the cost of material quality management and facilitate rehabilitation , The effect of simple preparation method

Inactive Publication Date: 2018-10-09
江苏黄河药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the single product content of azithromycin is high, the solubility is poor, and the bioavailability is low, so that the blood drug concentration of patients cannot reach the best

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A dispersible tablet of azithromycin, wherein 10 parts by weight of azithromycin, 4 parts by weight of a binding agent, 4 parts by weight of a disintegrant, and 1 part by weight of a lubricant;

[0027] The preparation method of azithromycin dispersible tablet comprises the following steps:

[0028] 1) Weigh 10 parts by weight of azithromycin, 2 parts by weight of sodium carboxymethylcellulose, and 4 parts by weight of crospovidone, and place them in a wet mixing granulator;

[0029] 2) Mix the mixture described in step 1) at 100-200r / min for 5-10min;

[0030] 3) Add 2 parts by weight of sodium carboxymethylcellulose into an appropriate amount of purified water, and stir repeatedly to form a uniform and clear liquid. ;

[0031] 4) Add the liquid described in step 3) into the wet mixing granulator, and mix at 100-200r / min for 1-2min;

[0032] 5) Make the azithromycin mixture described in step 4) into wet granules through a swing granulator, and dry at 50-60°C for 40 m...

Embodiment 2

[0036] A dispersible tablet of azithromycin, wherein 10 parts by weight of azithromycin, 4 parts by weight of a binding agent, 4 parts by weight of a disintegrant, and 1 part by weight of a lubricant;

[0037] The preparation method of azithromycin dispersible tablet comprises the following steps:

[0038] 1) Weigh 10 parts by weight of azithromycin, 2 parts by weight of sodium carboxymethylcellulose, and 4 parts by weight of croscarmellose sodium, and place them in a wet mixing granulator;

[0039] 2) Mix the mixture described in step 1) at 100-200r / min for 5-10min;

[0040] 3) Add 2 parts by weight of sodium carboxymethylcellulose into an appropriate amount of purified water, and stir repeatedly to form a uniform and clear liquid. ;

[0041] 4) Add the liquid described in step 3) into the wet mixing granulator, and mix at 100-200r / min for 1-2min;

[0042] 5) Make the azithromycin mixture described in step 4) into wet granules through a swing granulator, and dry at 50-60°C...

Embodiment 3

[0046] A dispersible tablet of azithromycin, wherein 10 parts by weight of azithromycin, 4 parts by weight of a binding agent, 4 parts by weight of a disintegrant, and 1 part by weight of a lubricant;

[0047] The preparation method of azithromycin dispersible tablet comprises the following steps:

[0048] 1) Weigh 10 parts by weight of azithromycin and 4 parts by weight of crospovidone, and place them in a wet mixing granulator;

[0049] 2) Mix the mixture described in step 1) at 100-200r / min for 5-10min;

[0050] 3) Add 4 parts by weight of sodium carboxymethylcellulose into an appropriate amount of purified water, and stir repeatedly to form a uniform and clear liquid. ;

[0051] 4) Add the liquid described in step 3) into the wet mixing granulator, and mix at 100-200r / min for 1-2min;

[0052] 5) Make the azithromycin mixture described in step 4) into wet granules through a swing granulator, and dry at 50-60°C for 40 minutes;

[0053] 6) Add the granules described in st...

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Abstract

The invention relates to the technical field of azithromycin preparations and particularly relates to an azithromycin dispersible tablet prepared from azithromycin, a disintegrating agent, a binder, and a lubricant; by organically combining the mentioned components, the tablet can be disintegrated quickly and stably with the disintegrating agent, thus quickly releasing active components, increasing bioavailability and reducing pain of patients.

Description

technical field [0001] The invention relates to the technical field of azithromycin preparations, in particular to an azithromycin dispersible tablet. Background technique [0002] Azithromycin is effective in the treatment of respiratory tract, skin, soft tissue infections and disseminated diseases caused by common pathogens. Compared with other antibiotics, azithromycin has made great progress in the treatment of respiratory and soft tissue infections in that the course of treatment is short (3-5 days), the dose is 10-15 times lower, and it only needs to be administered once a day. A major breakthrough in the treatment of sexually transmitted diseases requires only a single dose for chlamydia infection. Resistance to azithromycin is better than, or at least equal to, that of commonly used antibiotics [1]. Azithromycin is a macrolide antibiotic, which was first developed by Yugoslav Piliva Company and transferred to Pfizer Company of the United States for production. It w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/32A61K47/38A61K47/36A61K31/7052A61P31/04
CPCA61K9/0056A61K9/2027A61K9/2054A61K9/2059A61K31/7052A61P31/04
Inventor 朱正标张汉华裴雪梅范小雪刘耀文
Owner 江苏黄河药业股份有限公司
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