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Composite Au nano particle as well as preparation method and application thereof

A nanoparticle and metathesis reaction technology, applied in the field of composite Au nanoparticles and their preparation, can solve the problems of further improvement of photothermal efficiency, poor water solubility and the like

Active Publication Date: 2018-10-09
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Gold nanomaterials have also been extensively studied because of their stable physical and chemical properties, high photothermal efficiency and simple preparation methods; however, gold nanomaterials in the prior art have poor water solubility and photothermal efficiency needs to be further improved

Method used

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  • Composite Au nano particle as well as preparation method and application thereof
  • Composite Au nano particle as well as preparation method and application thereof
  • Composite Au nano particle as well as preparation method and application thereof

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preparation example Construction

[0026] The invention provides a kind of preparation method of composite Au nanoparticles, comprising the following steps:

[0027] (1) AlCl 3 , UCNPs mixed with ether to get AlCl adsorbed on the surface of UCNPs 3 ether solution;

[0028](2) adding ammonia dropwise to the surface of UCNPs obtained in step (1) to adsorb AlCl 3 A metathesis reaction occurs in the ether solution of UCNP@Al(OH) 3 core-shell structure;

[0029] (3) The UCNP@Al(OH) obtained in the step (2) 3 Core-shell structure with alendronate sodium and HAuCl 4 Mixing and carrying out a precipitation reaction to obtain a precipitated product;

[0030] (4) Mix the precipitated product obtained in step (3) with a reducing agent to undergo a redox reaction to obtain UCNP@Al(OH) 3 / Au nanoparticles.

[0031] The present invention will AlCl 3 , UCNPs mixed with ether to get AlCl adsorbed on the surface of UCNPs 3 ether solution. In the present invention, the UCNPs and AlCl 3 The molar ratio is preferably 1...

Embodiment 1

[0064] (1) Prepare UCNPs ether solution with a concentration of 0.067mol / L and AlCl with a concentration of 0.3mol / L 3 Diethyl ether solution, 10mLAlCl 3 Ether solution was added dropwise to 30mL UCNPs ether solution, stirred at room temperature for 1h and then centrifuged, and the precipitate was redispersed into 30mL ether solution to obtain AlCl adsorbed on the surface of UCNPs 3 ether solution;

[0065] (2) Under stirring at room temperature, add 500 μL of ammonia water with a mass concentration of 5% to the solution obtained in step 1) dropwise, react for 1 hour, and centrifuge to obtain UCNP@Al(OH) 3 core-shell structure;

[0066] (3) To prepare an aqueous solution of sodium alendronate with a concentration of 0.03mol / L, take 10mL aqueous solution of sodium alendronate and add it dropwise to 20mL of 0.1mol / L UCNP@Al(OH) 3 In the aqueous solution, stir at room temperature for 24 hours, centrifuge at 6000rpm for 3 minutes, and UCNP@Al(OH) 3 Nanoparticles were dispersed...

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Abstract

The invention provides a preparation method of a composite Au nano particle, and relates to the field of material chemistry and biological nano medicines. The preparation method comprises the following steps: (1) mixing AlCl3, UCNPs and diethyl ether to obtain a diethyl ether solution in which the AlCl3 is adsorbed on the surface of the UCNPs; (2) dropwise adding ammonia water into the diethyl ether solution in which the AlCl3 is adsorbed on the surface of the UCNPs, obtained in Step (1), so as to obtain a UCNP@Al(OH)3 core-shell structure; (3) mixing the UCNP@Al(OH)3 core-shell structure obtained in Step (2) with alendronate sodium and HAuCl4 for precipitation reaction, thus obtaining a precipitation product; and (4) mixing the precipitation product obtained in Step (3) with a reducer forredox reaction, thus obtaining the UCNP@Al(OH)3 / Au nano particle. The composite Au nano particle provided by the invention is excellent in water solubility and has efficient photo-thermal performance.

Description

technical field [0001] The invention belongs to the field of material chemistry and bionano medicine, and in particular relates to a composite Au nanoparticle and its preparation method and application. Background technique [0002] The new diagnosis and treatment technology of tumors is currently a research hotspot in the field of tumor treatment, especially the new non-invasive treatment methods represented by Photothermal Therapy (PTT) have great potential in the field of tumor treatment. However, the absorption spectrum of traditional photothermal therapy materials is in the ultraviolet-visible region, and there is no way to achieve better treatment efficiency for tumors in deep tissues. Therefore, a variety of nanomaterials with near-infrared light absorption capabilities have been introduced for deep-layer tumors. In the study of photothermal therapy of tissue tumors. Such as up-conversion nanoparticles, semiconductor quantum dots and gold nanomaterials. Gold nanomat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/00A61K9/51A61P35/00
CPCA61K9/5115A61K41/0052A61K49/0017A61K49/0056A61P35/00
Inventor 师冰洋张东亚王杰菲陈健
Owner HENAN UNIVERSITY
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