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Herba cistanche, herba cistanche extracted product, and applications of herba cistanche total glycoside extract product in cardiac neurosis

A technology of Cistanche deserticola extract and neurosis, which can be used in nervous system diseases, medical preparations containing active ingredients, drug combinations, etc., and can solve the problems of lack of proper exercise in the circulatory system.

Inactive Publication Date: 2018-10-19
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, overwork, too little physical activity, lack of proper exercise for the circulatory system, so that a little activity or a little fatigue can not adapt, resulting in excessive cardiovascular response and leading to this disease

Method used

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  • Herba cistanche, herba cistanche extracted product, and applications of herba cistanche total glycoside extract product in cardiac neurosis
  • Herba cistanche, herba cistanche extracted product, and applications of herba cistanche total glycoside extract product in cardiac neurosis
  • Herba cistanche, herba cistanche extracted product, and applications of herba cistanche total glycoside extract product in cardiac neurosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Invention of test substances on anxiety-like behavior in mice

[0023] 1. Experimental materials

[0024] 1.1 Drugs and reagents

[0025] Tested drugs: commercially available Cistanche medicinal materials, Cistanche total glycosides extract I (Example 5), Cistanche total glycosides extract II (Example 6);

[0026] Diazepam, Tianjin Lisheng Pharmaceutical Co., Ltd.

[0027] 1.2 Animals

[0028] ICR mice, weighing 18-22 g, male, SPF grade, provided by Beijing Weitong Lihua, license number: SCXK (Beijing) 2016-0011.

[0029] 1.3 Instruments

[0030] Rat and mouse elevated plus maze video experiment system, Shanghai Ruanlong Technology Development Co., Ltd.

[0031] 2. Experimental method

[0032] 50 male ICR mice were randomly divided into 5 groups according to body weight, including 10 blank control groups (administered with the same volume of purified water), 10 positive control groups (diazepam 1mg / kg), 2 groups of test drugs: Cistanche deserticola Her...

Embodiment 2

[0044] Embodiment 2: Research on the anti-fatigue effect of the invented test substance on mice

[0045] 1. Experimental materials

[0046] 1.1 Drugs and reagents

[0047] Tested drugs: commercially available Cistanche medicinal materials, Cistanche total glycosides extract I (Example 5), Cistanche total glycosides extract II (Example 6);

[0048] Panax ginseng granule, Jinri Pharmaceutical Co., Ltd.;

[0049] Urea nitrogen test box, Nanjing Jiancheng Bioengineering Research Institute;

[0050] Whole blood lactic acid assay kit, Nanjing Jiancheng Bioengineering Institute.

[0051] 1.2 Animals

[0052] ICR mice, weighing 18-22 g, male, SPF grade, provided by Beijing Weitong Lihua, license number: SCXK (Beijing) 2016-0011.

[0053] 1.3 Instruments

[0054] Morris water maze, Spanish Panlab company.

[0055] 2. Experimental method

[0056] 50 male ICR mice were randomly divided into 5 groups according to their body weight, including 10 blank control groups (administered w...

Embodiment 3

[0069] Embodiment 3: Experimental research on the sedative effect of the invented test substance on mice

[0070] 1. Experimental materials

[0071] 1.1 Drugs and reagents

[0072] Tested drugs: commercially available Cistanche medicinal materials, Cistanche total glycosides extract I (Example 5), Cistanche total glycosides extract II (Example 6);

[0073] Diazepam, Tianjin Lisheng Pharmaceutical Co., Ltd.

[0074] 1.2 Animals

[0075] ICR mice, weighing 18-22 g, male and female, SPF grade, provided by Beijing Weitong Lihua, license number: SCXK (Beijing) 2016-0011.

[0076] 1.3 Instruments

[0077] YLS-1A multi-function mouse autonomic activity recorder, Jinan Yiyan Technology Development Co., Ltd.;

[0078] Stopwatch, Dongsiyi (Beijing) Technology Co., Ltd.

[0079] 2. Experimental method

[0080] Before the experiment, it was first necessary to screen out that there was no significant difference in the number of autonomous activities of the mice in each group, that i...

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Abstract

The invention provides herba cistanche, a herba cistanche extracted product, and applications of a herba cistanche total glycoside extract product in cardiac neurosis. It is found in study on anti-anxiety, anti-fatigue, and sedative effects of the herba cistanche, the herba cistanche extracted product, and the herba cistanche total glycoside extract product in mice models that the herba cistanche,the herba cistanche extracted product, and the herba cistanche total glycoside extract product are capable of improving cardiac neurosis symptoms; and at the same time, it is shown by clinical experiments that the herba cistanche, the herba cistanche extracted product, and the herba cistanche total glycoside extract product can be used for safe and effective treatment of cardiac neurosis.

Description

technical field [0001] The present invention relates to the application of Cistanche deserticola, Cistanche deserticola extract and total glycoside extract of Cistanche deserticola in treating cardiac neurosis. Background technique [0002] Cardiac neurosis (cardiac neurosis) is also known as functional heart discomfort, nervous blood circulation weakness or effort syndrome (effortsyndrome), and cardiovascular neurosis Neurosis is a special type of neurosis, and it is also a very common cardiovascular disease. It is mainly manifested by dysfunction of the cardiovascular system, and may also have other manifestations of neurosis. Its symptoms are various, and common ones include palpitations, precordial pain, chest tightness, shortness of breath, dyspnea, dizziness, insomnia, and dreaminess. Most of them occur in young and middle-aged people, most of whom are 20 to 40 years old. It can also be seen in high- and high-level white-collar workers, empty-nest sick middle-aged and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/64A61P9/00A61P25/00A61P25/22A61P25/20A61P39/00A61K135/00
CPCA61K36/64A61K2236/13A61K2236/15A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61P9/00A61P25/00A61P25/20A61P25/22A61P39/00
Inventor 肖伟李芳杨绪芳邓奕周军曹亮王振中
Owner JIANGSU KANION PHARMA CO LTD
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