Nutritional formula with non-digestible oligosaccharides and non-replicating lactic acid producing bacteria

A lactic acid-producing bacteria, non-replicating technology, applied in the field of infant nutrition, can solve problems such as secretory IgA not mentioned

Inactive Publication Date: 2018-10-23
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although IgE and IgG levels are monitored, the document does not mention secretory IgA

Method used

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  • Nutritional formula with non-digestible oligosaccharides and non-replicating lactic acid producing bacteria
  • Nutritional formula with non-digestible oligosaccharides and non-replicating lactic acid producing bacteria
  • Nutritional formula with non-digestible oligosaccharides and non-replicating lactic acid producing bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1: Synergistic effect of an infant formula comprising non-replicating lactic acid producing bacteria selected from Bifidobacterium breve and Streptococcus thermophilus and non-digestible oligosaccharides on secretory IgA levels in infants

[0086] In a randomized, double-blind, controlled, parallel-group, prospective, multicenter, multinational, interventional study, subjects were randomized equally into four treatment groups. In addition, infants who had been exclusively breastfed (never received any infant formula) since birth and whose mothers intended to continue exclusive breastfeeding until at least 4 months of age were included in the breastfeeding reference group. A total of 350 subjects were enrolled, of which 280 subjects were randomly given any of the four test products and 70 subjects were included in the breastfeeding reference group.

[0087] Test Group 1: Infant Formula 1 is a modified cow's milk-based infant formula (Nutrilon 1 , marketed by Nutr...

Embodiment 2

[0104] Example 2: Consumption of infant formula comprising non-replicating lactic acid producing bacteria selected from Bifidobacterium breve and Streptococcus thermophilus and non-digestible oligosaccharides increases intestinal sIgA levels

[0105] In a randomized, multicenter, double-blind, prospective clinical trial, infants were enrolled before 28 days of age and assigned to receive one of three formulas until 17 weeks of age:

[0106] Test group 1: Infant formula 1 contains 66kcal per 100ml, 1.35g protein (bovine whey protein / casein, weight ratio is 1 / 1), 8.2g digestible carbohydrates (of which 5.6g lactose and 2.1g maltodextrin) , 3.0g fat (mainly vegetable fat), 0.8g contains scGOS in a weight ratio of 9:1 (source GOS) and lcFOS (source ) non-digestible oligosaccharides. On a dry weight basis, approximately 50% in this infant formula is derived from Lactofidus TM , a commercially available infant formula sold under the trade name Gallia. Lactofidus TM is a ferme...

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Abstract

A nutritional composition comprises non-digestible oligosaccharideandnon-replicating Bifidobacterium breveand/or Streptococcus thermophilussynergistically stimulates secretory IgA in infants.

Description

technical field [0001] The present invention relates to the field of infant nutrition for improving the mucosal immune system. Background technique [0002] It is generally accepted that the best nutrition for newborn babies is human milk. Infant formula (IF) based on mature human milk is considered the best alternative when mothers are unable to breastfeed their infants or choose not to breastfeed. Research to improve the quality of infant formula is not necessarily to mimic the precise composition of human milk, but to achieve functional effects beyond the nutritional aspects only observed in breastfed infants. [0003] Human milk is rich in secretory IgA (sIgA), which serves as the first line of defense to protect the intestinal barrier of infants from intestinal toxins and pathogenic microorganisms. sIgA is resistant to digestive enzymes and facilitates clearance of antigens and pathogenic microorganisms from the gut by blocking access to epithelial cell receptors, tra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00A23L33/135A23L33/21A61K31/702A61K35/744A61K35/745A61P37/04
CPCA61K45/06A61K31/702A61K35/744A61K35/745A23L33/40A23L33/135A23L33/21A61P37/04A61K2300/00
Inventor J·科诺尔H·鲍里迪尤斯A·R·奥泽尔A·J·纳奥塔
Owner NV NUTRICIA
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