Repairing gel as well as preparation method and application thereof

A gel and sol technology, applied in the field of skin care products, can solve the problems of limited promotion and application, poor preservation, and high prices of skin care products, and achieve the effects of enhancing curative effects, reducing prices, and relieving dry skin.

Pending Publication Date: 2018-11-02
广州领衔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, due to these shortcomings of bFGF in the application field, the price of bFGF-containing skin care products is relatively high. Generally, it is stored in a solid state after freeze-drying, and it needs to be reconstituted when used, which seriously limits its popularization and application.
[0006] Therefore, research and development of a bFGF-cont

Method used

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  • Repairing gel as well as preparation method and application thereof
  • Repairing gel as well as preparation method and application thereof
  • Repairing gel as well as preparation method and application thereof

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preparation example Construction

[0055] According to one aspect of the present invention, a kind of preparation method of repairing gel, described method comprises the following steps:

[0056] Firstly, the precursor sol is prepared by stepwise cooling and feeding. When the sol is cooled down to 29-32°C step by step, basic fibroblast growth factor bFGF is added and mixed evenly to obtain a repair gel.

[0057]The preparation method of the repairing gel provided by the present invention is to first prepare the precursor sol by adopting the method of step-by-step cooling and feeding, and when the sol is cooled to 29-32°C step by step, add basic fibroblast growth factor bFGF and mix well, Get Repair Gel. The above method adds basic fibroblast growth factor bFGF to the sol at 29-32°C, which can effectively avoid the problem of protein denaturation of bFGF caused by high temperature, and at the same time, adding bFGF at a certain temperature can make bFGF more evenly and fully dispersed in the Repairing Gel.

[...

Embodiment 1

[0068] A repair gel, which includes basic fibroblast growth factor bFGF and precursor sol;

[0069] The precursor sol is mainly made of the following raw materials in parts by weight:

[0070]

[0071] The mass ratio of the basic fibroblast growth factor bFGF to the precursor sol is 1:1,000,000.

Embodiment 2

[0073] A repair gel, which includes basic fibroblast growth factor bFGF and precursor sol;

[0074] The precursor sol is mainly made of the following raw materials in parts by weight:

[0075]

[0076]

[0077] The mass ratio of the basic fibroblast growth factor bFGF to the precursor sol is 2:1,000,000.

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Abstract

The invention provides repairing gel as well as a preparation method and application thereof, relating to the technical field of skin care products. The skin care gel is prepared from basic fibroblastgrowth factors bFGF and precursor sol; the mass ratio of the basic fibroblast growth factors bFGF to the precursor sol is (1-2) to 1,000,000. The bFGF can maintain relatively good stability in the precursor sol, and still has relatively good activity when stored for half a year in a normal temperature status through detection, thereby effectively remitting the problem that current bFGF ingredient-contained skin care products are difficult to preserve at normal temperature. Meanwhile, various ingredients in the precursor sol and various ingredients which cooperate with the bFGF in use not onlycan respectively give play to original effects but also can have a synergistic effect simultaneously, the curative effect of the repairing gel is further reinforced, and the repairing gel is obviously superior to current skin care products in remitting symptoms such as dry skin, senility, dark yellow, color spots, acne and allergy.

Description

technical field [0001] The invention relates to the technical field of skin care products, in particular to a repair gel and its preparation method and application. Background technique [0002] As early as 1940, Hoftman found a substance that could promote the growth of fibroblasts in the extracts of the brain and pituitary gland. In 1974, the substance was isolated and purified, and named as fibroblast growth factor (fibroblast growthfactor, FGF). Then people isolated a highly homologous substance, because it contains more acidic amino acid bases, and its isoelectric point is acidic (5.6), so it was named acidic FGF (aFGF). Acid and heat sensitive, the isoelectric point is alkaline (9.6), it is called basic FGF (bFGF). [0003] Basic fibroblast growth factor bFGF is a mitogenic cationic polypeptide containing 155 amino acids, with a molecular weight of 16-18.5KD. Success in purification by heparin-agarose affinity chromatography followed the high degree of purification ...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/9728A61K8/04A61Q19/00A61Q19/08
CPCA61K8/042A61K8/64A61K8/9728A61K2800/85A61Q19/00A61Q19/005A61Q19/08
Inventor 王宏刘斌王华英
Owner 广州领衔生物科技有限公司
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