Unlock instant, AI-driven research and patent intelligence for your innovation.

Biocompatible quantum dot and preparation method thereof

A biocompatible, quantum dot technology

Inactive Publication Date: 2018-11-13
TCL CORPORATION
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a biocompatible quantum dot and its preparation method, aiming at solving the problem of poor stability of existing quantum dots and low biocompatibility between quantum dots and organisms, which cannot meet the needs of modern biomedical fields. Application Requirements Questions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biocompatible quantum dot and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] Correspondingly, an embodiment of the present invention also provides a method for preparing biocompatible quantum dots, including the following steps:

[0022] S01. Provide oil-soluble quantum dots;

[0023] S02. Put the oil-soluble quantum dots in a mixed solution of an organic solvent and a surface modifier to obtain a surface-modified oil-soluble quantum dot; stir and mix the organic solvent and the emulsifier to prepare an inverse microemulsion; After the oil-soluble quantum dots are added to the reverse microemulsion and stirred, ammonia is added to form a water-oil microemulsion; a transparent amorphous insulating material source is added to the water-oil microemulsion, and the stirring process is performed to obtain a transparent amorphous insulating material encapsulating oil-soluble Quantum dot solution;

[0024] S03. Adjust the pH value of the solution in which the transparent amorphous insulating material wraps the oil-soluble quantum dots to 8-11, and add the fir...

Embodiment 1

[0038] A method for preparing biocompatible quantum dots includes the following steps. The schematic flow chart is as follows: figure 1 Shown:

[0039] S11. The preparation of near-infrared PbS quantum dots is as follows:

[0040] S111. Lead oleate{Pb(OA) 2 }Preparation of the precursor: Take 0.6mmol of lead acetate trihydrate, 2ml of oleic acid (OA), and 10ml of octadecene (ODE) into a three-necked flask, first exhaust at room temperature for 20 minutes, then raise the temperature to 150°C and stir for 30 minutes. The temperature drops to 120°C.

[0041] S112. Preparation of sulfur (S) precursor: Weigh 4mmol of S and add 6ml of trioctylphosphorus oxide (TOP), heat to 170°C for 30min, and then lower the temperature to 140°C.

[0042] S113. After raising the temperature of the mixture in S111 to 300°C, take 2ml of sulfur (S) precursor and quickly inject it into the flask to react for 10 minutes, and then extract 2ml of sulfur (S) source and inject it into the reaction mixture again A...

Embodiment 2

[0054] A method for preparing biocompatible quantum dots includes the following steps. The schematic flow chart is as follows: figure 1 Shown:

[0055] S21. The preparation of red CdSe quantum dots is as follows:

[0056] S211. Cadmium oleate{Cd(OA) 2 }Precursor preparation: Take 0.6mmol of cadmium oxide, 2ml of oleic acid (OA), and 10ml of octadecene (ODE) into a three-necked flask, first exhaust at room temperature for 20 minutes, then raise the temperature to 250°C and stir for 30 minutes. Reduce to 200°C.

[0057] S212. Preparation of sulfur (Se) precursor: weigh 4mmol of Se and add 6ml of trioctylphosphorus oxide (TOP), heat to 170°C for 30min, and then lower the temperature to 140°C.

[0058] S213. After raising the temperature of the mixture in S111 to 300°C, take 2ml of the selenium (Se) precursor and quickly inject it into the flask for 10 minutes, and then again extract 2ml of sulfur (S) source and inject it into the reaction mixture After reacting for 10 minutes, red CdSe...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a biocompatible quantum dot. The biocompatible quantum dot is of a core-shell structure comprising an oil-soluble quantum dot core, a transparent amorphous insulating material layer, a first surface modifier layer and a second surface modifier layer, wherein the transparent amorphous insulating material layer wraps the oil-soluble quantum dot core and is made from an inorganic transparent amorphous insulating material, the first surface modifier layer is formed on the surface of the transparent amorphous insulating material layer and made from a first surface modifier, the second surface modifier layer is formed on the surface of the first surface modifier layer and made from an organic second surface modifier.

Description

Technical field [0001] The invention belongs to the technical field of quantum dot synthesis, and particularly relates to a biocompatible quantum dot and a preparation method thereof. Background technique [0002] Quantum dots are a new type of semiconductor nanomaterials with unique size-dependent optoelectronic properties. As luminescent materials, they have the advantages of high energy efficiency, high stability, and wide color gamut. In recent years, colloidal quantum dots have been deeply studied and widely used in many fields, and related technologies have also been greatly developed, especially in the fields of quantum dot light-emitting diodes, solar cells, and biomarkers. The application of quantum dots in the field of biomarkers has attracted more and more attention, especially in the field of bioimaging technology. With the development of modern biomedicine, higher requirements have been put forward for quantum dots. For example, quantum dots can be transported freel...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/66C09K11/88
CPCC09K11/025C09K11/661C09K11/881
Inventor 程陆玲杨一行
Owner TCL CORPORATION