Subcutaneous medicine slow release device
A slow-release device and a technology for drugs, which are applied in the field of subcutaneous drug slow-release devices, can solve problems such as inability to release drugs in a controlled manner, incapable of intermittent drug delivery, etc., and achieve the effects of convenient implantation and suture positioning, low cost, and simple operation.
Active Publication Date: 2018-11-20
ZHEJIANG UNIV
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Problems solved by technology
Although the device can be embedded under the skin and has good biocompatibility, the drug release method is continuous and slow, and intermittent drug administration cannot be realized for a long time, and the drug release cannot be controlled, which has certain limitations.
Method used
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Effect test
Embodiment
[0071] Subcutaneous controlled intermittent release of parathyroid hormone.
[0072] 1. Using polycaprolactone (PCL) as the material, 3D printing is used to complete the device processing. The device is equipped with 15 drug release cells to meet the drug release requirements of two cycles (14 days), and the assembly is completed according to the drawings.
[0073] 2. Place the device in disinfectant alcohol and perform aseptic treatment under ultraviolet light for 12 hours.
[0074] 3. Take the gel microspheres made of parathyroid stimulating hormone and place them in 15 drug release cells in the drug storage tray at an amount of 20 μg / cell to complete the preparation of the drug release device.
[0075] 4. Place the drug release device under the skin at the corresponding position of the human body, and use the 4 fixing holes on the device to suture and fix it.
[0076] 5. Use the drive magnet drive device to release the medicine at the specified time every day. After releas...
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The invention discloses a subcutaneous medicine slow release device. The subcutaneous medicine slow release device comprises a base and a cover board, wherein a medicine applying opening is formed inthe cover board. The subcutaneous medicine slow release device also comprises a medicine storing disk in rotary connection to inner part of the base, a first driving mechanism and a second driving mechanism, wherein medicine storing cavities which are uniformly distributed in the circumferential direction are formed in the medicine storing disk, a medicine pushing board is arranged in each medicine storing cavity, and medicines are placed on the medicine pushing boards; the first driving mechanism is used for driving the medicine storing disk to perform intermittent rotation according to a setangle, and after rotation is completed each time, one of the medicine storing cavities is aligned with the medicine applying opening; and when a certain medicine storing cavity is aligned with the medicine applying opening, the second driving mechanism is used for driving the medicine pushing boards to push out the medicines. According to the subcutaneous medicine slow release device disclosed bythe invention, the medicines are released through magnetic force driving, the subcutaneous medicine slow release device is simple in structure, convenient in medicine release operation, low in cost,and safe and reliable, and subcutaneous controllable intermittent medicine release can be realized.
Description
technical field [0001] The patent of the present invention relates to a medical device for subcutaneous sustained-release drug administration, which belongs to medical equipment, and specifically relates to a subcutaneous drug sustained-release device embedded under the skin of a human body. Background technique [0002] Implantable drug delivery system (IDDS) is a kind of controlled drug release device implanted in the body or subcutaneously or introduced subcutaneously through surgery, and is a long-term drug delivery system. It overcomes the shortcomings of traditional drug administration methods during long-term administration, can stably control the drug concentration or blood drug concentration at the target site for a long time, and improve the bioavailability of the drug, thereby reducing the dosage and reducing side effects. [0003] The current IDDS can be divided into two categories: uncontrollable and controllable. After the uncontrollable IDDS is implanted in t...
Claims
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IPC IPC(8): A61M37/00A61K38/29A61P19/10
CPCA61K38/29A61M37/00A61M2205/04A61P19/10
Inventor 贺永周璐瑜高庆傅建中
Owner ZHEJIANG UNIV