NSCLC (non-small cell lung cancer) detection kit and application thereof

Abstract

The invention discloses an NSCLC (non-small cell lung cancer) detection kit and an application thereof. The NSCLC detection kit comprises substances for detecting the content of 9 miRNAs (miRNA-hsa-miR-20a, hsa-miR-25, hsa-miR-223, hsa-miR-320, hsa-miR-222, hsa-miR-146a, hsa-miR-191, hsa-miR-24 and hsa-miR-130a), CEA and CYFRA21-1. The kit can be used for well screening NSCLC and is high in sensitivity, high in specificity and suitable for screening of NSCLC, particularly for NSCLC at the early stage. Therefore, early warning can be given for the lung cancer risk of people by use of the 9 miRNAs in combination with the CEA and CYFRA21-1, and the early diagnosis proportion can be increased.

Description

technical field [0001] The invention relates to a non-small cell lung cancer detection kit and its application in the field of biomedicine. Background technique [0002] Lung cancer is one of the most common malignant tumors clinically. Lung cancer is mainly divided into small cell lung cancer and non-small cell lung cancer. The main type of lung cancer in my country is non-small cell lung cancer, accounting for about 80% of lung cancer patients, mainly including two types of adenocarcinoma and squamous cell carcinoma. Early detection and early treatment of lung cancer patients are very likely to improve the survival rate and reduce mortality of lung cancer patients. [0003] At present, the commonly used diagnosis of lung cancer mainly relies on the finding of intrapulmonary tumors on imaging, including chest X-ray, CT, nuclear magnetic resonance (MRI) and other imaging methods, combined with tumor markers such as carcinoembryonic antigen in serum. However, imaging exami...

AI Technical Summary

Problems solved by technology

However, different research groups mostly use a single reference miRNA for data normalization, and the markers screened by different NSCLC studies are quite different, and the diagnostic value of some miRNAs varies greatly in different research reports

In addition, there are few reports on the complementarity between miRNA and tumor protein markers, and the specificity to benign and malignant diseases of other tissues and organs.

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