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GRP78 gene SNP (Single Nucleotide Polymorphism) marker related to asthenospermia, and application thereof

An asthenozoospermia and marker technology, applied in the fields of genetic engineering and reproductive medicine, can solve the problems such as the lack of related research reports on male infertility and asthenozoospermia of GRP78 gene polymorphism, and the lack of markers for the onset risk of asthenozoospermia.

Inactive Publication Date: 2018-11-23
AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIV FOR NATTIES
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Problems solved by technology

Studies have reported that there are differences in the expression of GRP78 protein between the normal sperm motility group and the asthenozoospermia group, that is, the expression of GRP78 protein in the asthenospermia group is relatively decreased, suggesting that GRP78 is closely related to the occurrence of asthenospermia, but so far, there is no There are reports on the correlation between GRP78 gene polymorphisms and male infertility and asthenospermia, and there is currently a lack of specific and obvious markers to determine its association with the risk of asthenospermia

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  • GRP78 gene SNP (Single Nucleotide Polymorphism) marker related to asthenospermia, and application thereof
  • GRP78 gene SNP (Single Nucleotide Polymorphism) marker related to asthenospermia, and application thereof
  • GRP78 gene SNP (Single Nucleotide Polymorphism) marker related to asthenospermia, and application thereof

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Embodiment

[0028] research object

[0029] This experiment was approved by the Ethics Committee of the Affiliated Hospital of Youjiang Medical University for Nationalities, and 400 patients with asthenozoospermia and 400 healthy men with normal reproductive history were recruited. 400 patients with asthenozoospermia were taken as the case group (i.e., less than 32% of the forward motility sperm (a and b grades), other semen parameters and biochemical indicators were normal), all of them had normal sex life after marriage and had no contraception. Cohabitation for 18 months or more is infertile, and the inspection indicators of the spouse are normal, and there is no history of infertility. Patients with infertility caused by endocrine gland hypofunction, Y chromosome microdeletion, abnormal karyotype, obstruction of the vas deferens, varicocele, cryptorchidism, orchitis, epididymitis, and history of reproductive tract infection were excluded. The control group was healthy men with normal...

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Abstract

The invention discloses a GRP78 gene SNP (Single Nucleotide Polymorphism) marker related to asthenospermia, and application thereof, and relates to the technical field of genetic engineering and reproductive medicine. A multiple single base extension technology is adopted to analyze the correlation of the polymorphism of a plurality of locus of the GRP78 gene and the asthenospermia to obtain thatGRP78 genes rs3216733 and rs391957 SNP have correlation with the occurrence of the asthenospermia, protein expression can be lowered to increase an asthenospermia occurrence risk, and the GRP78 gene SNP marker can be used as reagent or a kit for assisting in diagnosing the asthenospermia.

Description

technical field [0001] The invention relates to the technical fields of genetic engineering and reproductive medicine, in particular to an asthenozoospermia-related GRP78 gene SNP marker and its application. Background technique [0002] The incidence of infertility is increasing year by year, seriously affecting about 10% to 15% of couples of childbearing age, and the male factor is considered to play a vital role in infertility. The causes of male infertility are complex and diverse, among which asthenospermia is one of the important pathogenic factors. Asthenozoospermia refers to a disease in which sperm motility decreases and leads to male infertility, manifested as less than 32% of forward motility sperm. Its pathogenesis is related to infection, abnormal semen liquefaction, endocrine factors, immune factors, genetic factors, etc., but it has not been fully elucidated so far. In recent years, studies on the correlation between single nucleotide polymorphism (SNP) and ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12Q1/6858C12N15/11
CPCC12Q1/6858C12Q1/6883C12Q2600/156C12Q2600/172C12Q2533/101C12Q2537/143
Inventor 王俊利罗小琼韦玉霞韦敬锡李妹燕蒙县宗廖碧云陈兴鸿覃海媚庞晓霞
Owner AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIV FOR NATTIES
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