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Application of chimonanthus plant extracts in preparing medicines

A plant extract and extract technology, applied in the field of medicine, can solve the problems of large toxic and side effects, easy secondary drug resistance, serious side effects, etc.

Inactive Publication Date: 2018-12-04
浙江华润三九众益制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, it has serious toxic and side effects, easy secondary drug resistance, superinfection, patient compliance and other problems.
Drugs for clinical treatment mainly include steroidal (SAID) and non-steroidal (NSAID) anti-inflammatory drugs. Although there are many available drugs, most of them have serious side effects

Method used

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  • Application of chimonanthus plant extracts in preparing medicines
  • Application of chimonanthus plant extracts in preparing medicines
  • Application of chimonanthus plant extracts in preparing medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0196] Take the crushed medicinal material, put it into a round bottom flask, and add water twice to reflux for extraction. Add 10-16 times of water for the first time, filter after 1 hour of extraction, add 8-12 times of water for the second time, extract for 1 hour, and combine the two filtrates. Concentrate on a rotary evaporator or concentrate on a water bath, water bath at 75°C, rotating speed 80rpm, concentrate to a specific gravity of 1.18-1.22, pour it into a stainless steel pan, place it in a vacuum drying oven at 65°C, dry it in a vacuum and then pulverize it. The code number of the water extract of Wintersweet is LYS, the number of water extract of Zhejiang Wintersweet is ZYS, and the code of water extract of Wintersweet is SYS.

[0197]

[0198]

[0199] 2. Alcohol extracts of 3 varieties

Embodiment 5-7

[0201] Alcohol extraction: take the dried and old leaves of the willow-leaved wintersweet and crush the medicinal materials, put them into a round-bottomed flask, and add ethanol twice for reflux extraction. Add 10 times of ethanol for the first time, filter after 1 hour of extraction, add 8 times of ethanol for the second time, extract for 1 hour, and combine the two filtrates. Concentrate on a rotary evaporator, water bath at 65°C, rotating speed at 80rpm, concentrate until the specific gravity is 1.18-1.22, pour it into a stainless steel pan, put it in a decompression drying oven at 65°C, dry it in a vacuum and crush it.

[0202]

[0203] 3. Three types of steam distilled volatile oils

Embodiment 8-11

[0205] Weigh an appropriate amount of crushed medicinal materials, put them into 5-20 times of water for extraction, install the volatile oil extractor, and collect after the oil is produced.

[0206]

[0207] 4. Supercritical Extract (Wursanthus osmanthus)

[0208] 4.1 Supercritical without entrainer

[0209] 4.1.1 Collection without separating the separation kettle

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PUM

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Abstract

The invention discloses an application of chimonanthus plant extracts in preparing medicines, and in particular relates to an application of chimonanthus plants and extracts thereof in preparing medicines for preventing / treating various diseases. The chimonanthus plants include chimonanthus salicifolius, chimonanthus zhejiangensis or chimonanthus nitens; and the extracts are obtained by aqueous extraction, alcohol extraction, steam distillation and supercritical extraction.

Description

technical field [0001] The invention specifically relates to a preparation method and a pharmaceutical use of an extract of the genus Wintersweet, which includes wax plums, Zhejiang wintersweet or mountain wintersweet, and belongs to the technical field of medicine. Background technique [0002] 1. Wintersweet [0003] Wintersweet (Chimonanthus salicifolius S.Y.Hu), Zhejiang wintersweet (Chimonanthuszhejiangensis M.C.Liu) or mountain wintersweet (Chimonanthus nitens Oliv.) are common folk medicines of the She people. Since the Northern Song Dynasty, their dried leaves have been taken as herbal teas , has been used for the treatment and prevention of colds for nearly a thousand years. Modern research has progressed again. Among them, the granule preparation prepared from the extract of wintersweet has a good effect on treating / preventing colds and has been sold in the market; wax plum and Zhejiang wintersweet have been included in the "Zhejiang traditional Chinese medicine p...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P29/00A61P31/00A61P31/04A61P31/06A61P31/16A61P31/22A61P31/14
CPCA61K36/185A61K2236/33A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/51A23K10/30
Inventor 王子厚葛发欢陈昌红袁宙新李水福马领弟范蕾
Owner 浙江华润三九众益制药有限公司
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