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Albendazole mixed suspension liquid and preparation method thereof

A technology of albendazole and suspension, which is applied in the field of albendazole suspension and its preparation, which can solve the problems of dosage for livestock vomiting, cumbersome feeding operation, and influence on deworming effect, and achieve the suspension effect Good, uniform distribution, good emulsifying effect

Inactive Publication Date: 2018-12-14
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since albendazole is an insoluble substance, it is neither soluble in water nor in most organic solvents, but only soluble in some acids, so its application is greatly limited
At present, the widely used albendazole preparation is only tablets. In the use of animal husbandry, due to the cumbersome feeding operation when used in livestock, it is easy to cause vomiting in livestock, resulting in inaccurate dosage and affecting the deworming effect.

Method used

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  • Albendazole mixed suspension liquid and preparation method thereof
  • Albendazole mixed suspension liquid and preparation method thereof
  • Albendazole mixed suspension liquid and preparation method thereof

Examples

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preparation example Construction

[0046] The preparation method of above-mentioned albendazole suspension, comprises the following steps:

[0047] (1) Weigh the prescribed amount of Span 60, add water, stir and heat to about 60°C to fully dissolve;

[0048] (2), take the Tween 85 of recipe quantity, join in the solution of step (1), stir rapidly with mixer, make emulsifying agent fully emulsify;

[0049] (3), weigh the sodium citrate and potassium sorbate in the prescription quantity, dissolve in water, then add in the emulsion of step (2), fully stir;

[0050] (4), take the hydroxypropyl methylcellulose of recipe quantity, add in the emulsion of step (3), fully stir;

[0051] (5), take by weighing the polyethylene glycol 300 of recipe quantity, add in the emulsion of step (4), fully stir;

[0052] (6), take the albendazole of recipe quantity, add in the emulsion of step (5), fully stir;

[0053] (7), add water in the mixture of step (6), stir while adding, constant volume with water;

[0054] (8) Regulate...

Embodiment 1

[0060] (1) Weigh 1 kg of Span 60, add water, stir and heat until fully dissolved at about 60°C, and pour it into a liquid mixing container;

[0061] (2) Take by weighing 11kg of Tween 85, join in the solution of step (1), stir rapidly with agitator, fully emulsify the emulsifier;

[0062] (3) Take by weighing 1kg sodium citrate and 250g potassium sorbate, dissolve in water, then add in the emulsion of step (2), fully stir;

[0063] (4) Take by weighing 13g hydroxypropyl methylcellulose, add in the emulsion of step (3), fully stir;

[0064] (5) Take by weighing 5.5kg polyethylene glycol 300, add in the emulsion of step (4), fully stir;

[0065] (6) Take 10kg of albendazole, add in the emulsion of step (5), fully stir;

[0066] (7) Add water to the mixture of step (6), stir while adding, and set the volume to 100L with water;

[0067] (8) Use the glacial acetic acid in the prescription to adjust the pH to 5.0-7.0 to obtain the veterinary albendazole suspension.

Embodiment 2

[0069] (1) Weigh 2kg of Span 60, add water, stir and heat to about 60°C to fully dissolve;

[0070] (2) Tween 85 of 14kg is weighed, joined in the solution of step (1), stirs rapidly with agitator, fully emulsifies emulsifying agent;

[0071] (3) Take by weighing 1kg sodium citrate and 250g potassium sorbate, dissolve in water, then add in the emulsion of step (2), fully stir;

[0072] (4) Take by weighing 13g hydroxypropyl methylcellulose, add in the emulsion of step (3), fully stir;

[0073] (5) Take by weighing 5.5kg polyethylene glycol 300, add in the emulsion of step (4), fully stir;

[0074] (6) Take 10kg of albendazole, add in the emulsion of step (5), fully stir;

[0075] (7) Add water to the mixture of step (6), stir while adding, and set the volume to 100L with water;

[0076] (8) Use the glacial acetic acid in the prescription to adjust the pH to 5.0-7.0 to obtain the veterinary albendazole suspension.

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Abstract

The invention relates to the technical field of veterinary medicines and discloses an albendazole mixed suspension liquid and a preparation method thereof. Each 100 ml of the mixed suspension liquid comprises, by volume, 10% to 20% of albendazole, 12% to 16% of an emulsifier, 0.013% to 0.015% of a thickener, 1% to 1.5% of a stabilizer, 5.5% to 6% of a suspending agent, 0.25% to 0.3% of a preservative, an acidity regulator and the balance of filling water. The albendazole mixed suspension liquid solves the problem that the existing albendazole tablets are difficult to feed to the livestock, have complex operation processes, easily cause vomiting, have good emulsification effects and prevent layering in one week. Albendazole is uniformly distributed in the suspension liquid, effectively prevents the poisoning or dose inaccuracy caused by unevenness of the suspension liquid and keeps the effect of deworming. The albendazole mixed suspension liquid has a wide application range, can be mixed with water at any ratio, has good mixing suspension effects, can be suspended for a long time and can prevent drug poisoning caused by drug precipitation.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to albendazole suspension and a preparation method thereof. Background technique [0002] Albendazole (Albendazole), also known as albendazole, belongs to benzimidazoles, and its chemical name is 5-propylthio-1H-benzimidazole-2-methyl carbamate. It is a broad-spectrum, high-efficiency, low- Poisonous veterinary anthelmintics. It is highly active against nematodes, schistosomes, and tapeworms, and has a significant inhibitory effect on the development of eggs. It also has obvious repelling effect on various nematodes, schistosomes, tapeworms and cysticercosis parasitic on animals. [0003] Since albendazole is an insoluble substance, it is neither soluble in water nor in most organic solvents, but only soluble in some acids, so its application is greatly limited. At present, the widely used albendazole preparation is only tablets. In the use of animal husbandry, due to...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K47/26A61K47/22A61K47/38A61K47/10A61K31/4184A61P33/10
CPCA61K9/10A61K31/4184A61K47/10A61K47/22A61K47/26A61K47/38A61P33/10
Inventor 刘重智刘肖娟袁增辉谭志坚黎剑坤符德文陈艺青
Owner FOSHAN STANDARD BIO TECH
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