Sulfasalazine Tablet Preparation Method

A technology of sulfasalazine tablet and sulfasalazine, which is applied in the field of sulfasalazine tablet making mold, sulfasalazine tablet making device, and sulfasalazine tablet making, which can solve the problem of price increase and cost reduction , unfavorable and other problems, to achieve the effect of stable weight, cost reduction and simple structure

Active Publication Date: 2021-03-02
SUZHOU HUANGHE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Tablet pressing (tablet pressing is the process of pressing and processing materials and suitable auxiliary materials into tablet preparations with a tablet machine), each process needs to be equipped with special equipment, which leads to an increase in the price of traditional sulfasalazine production equipment. Helps reduce costs

Method used

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  • Sulfasalazine Tablet Preparation Method
  • Sulfasalazine Tablet Preparation Method
  • Sulfasalazine Tablet Preparation Method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1, this embodiment is a mold for making sulfasalazine tablets.

[0075] see Figure 1-Figure 9 The tablet-making mold of sulfasalazine in this embodiment includes a tablet-making mold 1 , and the tablet-making mold 1 includes an upper mold 11 , a lower mold 12 and a stopper 13 .

[0076] The upper mold 11 is provided with a penetrating tablet-making chamber 111 , and the lower mold 12 is provided with a tablet-making jack post 121 , and the tablet-making jack post 121 is inserted into the tablet-making chamber 111 snugly. Usually, the cross-section of the film-making chamber 111 and the cross-sectional shape of the film-making push column 121 are the same and are circular. The section of the film chamber 111 and the section of the film-making top column 121 are square, triangular or the like. Usually, the upper mold 11 and the lower mold 12 are made of medical stainless steel or medical ABS.

[0077] The limiting member 13 includes a limiting bar 131 , the...

Embodiment 2

[0086] Embodiment 2, this embodiment is a tablet-making device for sulfasalazine.

[0087] see Figure 10-Figure 15 , The sulfasalazine tablet-making device of this embodiment includes a tablet-making device 2 , and the tablet-making device 2 includes a transport unit 21 ; the transport unit 21 includes a transport device 211 . The conveying device 211 is usually a power belt, and may also be a linear conveying device such as a power chain or a power chain plate. Usually, the conveying part 21 further includes a frame 212 fixedly connected with the conveying device 211 for supporting the conveying device 211 .

[0088] The tablet making device 2 also includes a coating machine 22 fixedly arranged above the conveying device 211 . Usually, the coater 22 is a conventional roller coater [in the accompanying drawings, the details of the coater 22 are drawn], such as the DCM-36 coater of Nanjing Xiante Automation Equipment Co., Ltd., of course It can be a coating machine of other...

Embodiment 3

[0102] Embodiment 3, this embodiment is a method for preparing tablets of sulfasalazine.

[0103] Sulfasalazine tablet preparation method, comprises the following steps:

[0104] S1, mixing and stirring sulfasalazine powder and water to make sulfasalazine ointment 3. In the sulfasalazine powder, one or more of conventional disintegrants (such as starch, etc.), lubricants, and glidants (such as talc powder, micronized silica gel, hydrogenated vegetable oil, etc.) are usually added. Mixing, stirring is usually done in a conventional blender. Sulfasalazine ointment 3 usually determines the appropriate penetration through experiments to facilitate application.

[0105] S2, coating the sulfasalazine ointment 3 on the tablet-making mold 1 to obtain the tablet-making mold 1 coated with the sulfasalazine ointment 3 . The coating of the sulfasalazine ointment 3 is usually completed on the above-mentioned tablet making device 2 .

[0106] In S2, a step S21 of extruding the tablet-ma...

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Abstract

The present invention relates to a tablet-making method of sulfasalazine, which uses a tablet-making mold, and the tablet-making mold includes an upper mold, a lower mold and a limiting member; the upper mold is provided with a penetrating tablet-making cavity, and the lower mold is provided with a tablet-making top column, The film-making top pillars are inserted into the film-making cavity in a fit manner; the limiting member includes a limiting bar, and the top surface of the limiting bar and the bottom end surface of the limiting bar are respectively against the upper mold and the lower mold; it includes the following steps: Sulfasalazine powder and water are mixed and stirred to make sulfasalazine ointment; the sulfasalazine ointment is coated on a tablet mold to obtain a tablet mold coated with sulfasalazine ointment; the sulfasalazine ointment coated with The tablet-making mold of azasalazine ointment is dried to obtain the tablet-making mold equipped with sulfasalazine tablets; the upper mold is brought close to the lower mold so that the tablet-making top column ejects the sulfasalazine tablet to obtain sulfasalazine tablets. Pyridine tablets. The sulfasalazine tablet-making method of the invention has simple procedures, is beneficial to cost reduction, and can ensure the weight stability of the sulfasalazine tablet.

Description

technical field [0001] The invention relates to the technical field of sulfasalazine production, in particular to a sulfasalazine tablet-making mold, a corresponding sulfasalazine tablet-making device, and a corresponding sulfasalazine tablet-making method. Background technique [0002] The traditional production of sulfasalazine is all through, [0003] Crushing (crushing is mainly the operation process of finely pulverizing solid materials by mechanical force), [0004] Sieving (sieving is the operation of separating mixed materials of different particle sizes according to particle size), [0005] Mixing (mixing is the operation of uniformly mixing two or more components) [0006] Granulation (granulation is the operation of processing materials in the state of powder, molten liquid, aqueous solution, etc. into granular objects with a certain shape and size), [0007] Drying (drying is the operation of using heat energy to vaporize the moisture in the material, and usin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61J3/00
CPCA61J3/00A61J2200/20A61J2200/42
Inventor 肖祖华江尔胜
Owner SUZHOU HUANGHE PHARMA CO LTD
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