A method for calculating coronary blood flow reserve fraction based on porous medium theory
A technology of coronary blood flow and porous media, applied in blood flow measurement, complex mathematical operations, medical science, etc., can solve problems such as blood flow and microcirculation resistance distribution not in line with human hemodynamic distribution, and achieve wide applicability , the effect of good precision
Inactive Publication Date: 2019-01-01
DALIAN UNIV OF TECH
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[0006] The purpose of the present invention is to solve the problem that the distribution of blood flow and microcirculation resistance at the outlet of each branch at the far end of the coronary artery does not conform to human hemodynamics when calculating the coronary artery fractional flow reserve (FFR) based on computational fluid dynamics (CFD) numerical simulation. In order to solve the problem of the distribution of blood vessels, a more accurate calculation method of coronary artery fractional flow reserve (FFR) based on the theory of porous media is proposed, and the flexible properties of the vessel wall and the factors of static or moving objects in the vessel lumen are considered.
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[0028] The calculation example ( Figure 4 ) and calculation examples of moving foreign bodies in coronary vessels ( Figure 5 ), clearly and completely describe the technical solutions in the implementation cases of the present invention. The described embodiments are only some, not all, embodiments of the present invention. All other embodiments obtained by persons of ordinary skill in the art based on the implementation cases in the present invention belong to the protection scope of the present invention.
[0029] figure 1 It is a work flow diagram of a calculation method for coronary artery fractional flow reserve (FFR) based on the porous medium theory. First (step 1), the vascular lumen enveloped by the patient's coronary vessels is obtained by coronary CTA technology. Three-dimensional spatial geometric shape data; obtain the patient's coronary artery aortic inlet pressure p by measuring diastolic pressure and myocardial mass inlet and flow Q inlet data; obtain th...
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The invention relates to a method for calculating coronary artery blood flow reserve fraction based on porous medium theory, belonging to the field of biomechanics, hemodynamics and computational fluid dynamics. The purpose of this paper is to solve the problem of calculating coronary blood flow reserve fraction (FFR) based on computational fluid dynamics (CFD) numerical simulation, and the distribution of blood flow and microcirculatory resistance at the distal branches of coronary artery does not accord with the distribution of human hemodynamics. A more accurate calculation method of coronary flow reserve fraction (FFR) based on pore medium theory is proposed. Considering the flexibility of vessel wall and the presence of stationary or moving objects in vessel lumen, this method has better accuracy and wider applicability than the one with rigid vessel wall and only fluid medium in blood. The invention can be used for clinical examination of human cardiac coronary artery occlusion.
Description
technical field [0001] The invention relates to the fields of biomechanics, hemodynamics and computational fluid dynamics, in particular to a method for calculating coronary artery fractional flow reserve (FFR) based on pore medium theory. Background technique [0002] Interventional coronary angiography (ICA) is an effective method that has been used in the clinical diagnosis of coronary atherosclerotic heart disease (CHD for short), and is considered to be the "gold standard" for diagnosing CHD at this stage. However, the latest research shows that interventional coronary angiography (ICA) can only identify the degree of stenosis of the patient's coronary vessels from the image, and cannot provide a direct basis for clinical and physiological diagnosis, that is, it cannot accurately diagnose whether a certain coronary stenosis can cause myocardial infarction. Ischemic injury has a certain probability of misdiagnosis. In addition, interventional coronary angiography (ICA) ...
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Login to View More IPC IPC(8): A61B5/02A61B5/026G06F17/11
CPCA61B5/02007A61B5/02028A61B5/026G06F17/11
Inventor 韩瑞琪宿晓辉赵镛韩少峰陆遥
Owner DALIAN UNIV OF TECH