Ceramide lipidosome and preparation method thereof

A technology of ceramide lipid and ceramide, which is applied in the field of ceramide liposome and its preparation, can solve the problems of limiting the wide application of ceramide, and achieve the effects of good moisturizing effect, good water dispersibility and high transparency

Inactive Publication Date: 2019-01-01
苏州纳康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The above problems greatly limit the wide application of c...

Method used

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  • Ceramide lipidosome and preparation method thereof
  • Ceramide lipidosome and preparation method thereof
  • Ceramide lipidosome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: a kind of preparation method of ceramide liposome adopts the following steps:

[0025] A. Weigh 7.5g of ceramide, 3g of cholesterol, 4.5g of fatty acid, 8.5g of ceteth-25, and 0.5g of glyceryl stearate. After weighing, put them in a 150mL beaker and place them in a water bath at 88°C for 200r / min Stir until it melts evenly to obtain an oil phase;

[0026] B. Weigh 5g of deionized water, heat it in a water bath to 88°C, add it into the oil phase obtained in step 1 under the condition of stirring at 200r / min, then naturally cool it to 32°C under the condition of stirring, and then heat it to 88°C in a water bath, so high The low temperature cycle was performed twice, and the obtained solution was homogenized once under a pressure of 800 bar to obtain an emulsion;

[0027] C. Weigh 48g of deionized water, 5g of lecithin, and 18g of sorbitol, and dissolve them uniformly in a water bath at 88°C to obtain the outer aqueous phase;

[0028] D. Slowly inject the...

Embodiment 2

[0030] Embodiment 2: a kind of preparation method of ceramide liposome adopts the following steps:

[0031] A. Weigh 2.5g of ceramide, 1g of cholesterol, 1.5g of fatty acid, 5.5g of glyceryl myristate, and 212g of steareth-212g. After weighing, put it into a 150mL beaker and place it in a water bath at 85°C at 200r / min. Stir until it melts evenly to obtain an oil phase;

[0032] B. Weigh 6g of deionized water, heat it in a water bath to 85°C, add it into the oil phase obtained in step 1 under the condition of stirring at 200r / min, then naturally cool it to 35°C under the condition of stirring, and then heat it to 85°C in a water bath, so high The low temperature cycle was performed twice, and the obtained solution was homogenized once under a pressure of 1000 bar to obtain an emulsion;

[0033] C. Weigh 52.5g of deionized water, 19g of sorbitol, and 10g of lecithin, and dissolve them uniformly in a water bath at 85°C to obtain an outer aqueous phase;

[0034] D. Slowly injec...

Embodiment 3

[0036] Embodiment 3: a kind of preparation method of ceramide liposome adopts the following steps:

[0037] A. Weigh 5g of ceramide, 2g of cholesterol, 3g of fatty acid, 3g of Tween 80, 0.5g of Span 80, and 6g of glyceryl stearate, weigh them and put them in a 150mL beaker, and put them in a 90°C water bath at 200r / min Stir until melted evenly, the oil phase;

[0038]B. Weigh 5g of deionized water, heat it in a water bath to 90°C, and add it to the oil phase obtained in step 1 under the condition of stirring at 200r / min, then naturally cool it to 40°C under the condition of stirring, and then heat it to 90°C in a water bath, so high Low temperature cycle 3 times, homogenize the obtained solution once under 1000 bar pressure, to obtain emulsion;

[0039] C. Weigh 48.5g of deionized water, 20g of sorbitol, and 7g of lecithin, and dissolve them uniformly in a water bath at 90°C to obtain the outer aqueous phase;

[0040] D. Slowly inject the emulsion obtained in step B into the...

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Abstract

The invention relates to a ceramide lipidosome. The ceramide lipidosome is characterized by comprising ceramide, cholesterol, fatty acid, lecithin, emulgator, sorbitol and deionized water at mass ratio of 5:2:3:(2-20):(0.25-15):(10-25):(20-60), wherein the emulgator is selected from one or mixture of stearyl alcohol polyether-21, stearyl alcohol polyether-2, glyceryl stearate, glyceryl laurate, glyceryl myristate, span 80, tween 80, tween 60, span 60, cetyl alcohol polyether-25, cetyl alcohol polyether-6 and laureths-23. The ceramide lipidosome prepared according to the invention has the advantages of excellent water dispersibility, high stability, excellent transdermal absorption, being approximate to physiologic lipid of human skin, high transparence of aqueous dispersion, and the like.

Description

technical field [0001] The invention relates to the technical field of nano liposome preparation, in particular to a ceramide liposome and a preparation method thereof. Background technique: [0002] The barrier function of the skin mainly depends on the stratum corneum of the epidermis. The stratum corneum of the epidermis is composed of protein-rich keratinocytes and intercellular lipids, which are called physiological lipids of human skin. The lipid chemical composition is 50% ceramide, 20% of cholesterol and cholesteryl ester and 30% of free fatty acid play a vital role in maintaining the stability of the internal environment and preventing physical, chemical and biological damage from the external environment. Studies have proved that the intercellular lipids of the stratum corneum form a double-layer lipid structure and fill between the corneocytes, which can effectively prevent the loss of water, nutrients and electrolytes in the body, and have a deep moisturizing eff...

Claims

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Application Information

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IPC IPC(8): A61K8/68A61K8/14A61K31/164A61K9/127A61P17/00A61Q19/00
CPCA61P17/00A61Q19/00A61K8/14A61K8/68A61K9/127A61K31/164
Inventor 马超龙徐静朱金花
Owner 苏州纳康生物科技有限公司
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