Method for preparing manganese nicotinate and application of manganese nicotinate to animal feed

Abstract

The invention discloses a method for preparing manganese nicotinate. The method includes steps of adding nicotinic acid into water; adding manganese sources into the water and carrying out stirring reaction; carrying out cooling after the reaction is sufficiently completely carried out; separating solid from liquid; washing and drying obtained solid products to obtain the manganese nicotinate. ThepH (potential of hydrogen) values of reaction systems are controlled in whole procedures during stirring reaction, so that the reaction systems are weakly acidic. The invention further discloses application of the manganese nicotinate to animal feed. The method and the application have the advantages that the method is simple, is short in reaction time, low in cost and high in production efficiency and only has low requirements on equipment, the manganese nicotinate which is a product prepared by the aid of the method is high in yield and purity, the yield can reach 95% at least on the basisof manganese, and the purity of the product can reach 98% at least; excellent growth promoting effects can be realized for poultry animals when the manganese nicotinate is used in poultry feed, and the quality of carcasses can be improved; the reproductive performance of reproductive sow can be particularly greatly improved when the manganese nicotinate is used in pig feed; effects of obviously improving the growth performance and reducing the death rates can be realized when the manganese nicotinate is used in aquatic feed; effects of increasing the milk quantities of ruminant animals and reducing the mastitis incidence can be realized when the manganese nicotinate is used in ruminant feed.

Description

technical field

[0001] The invention belongs to the field of preparation of feed additives, in particular to a preparation method of manganese nicotinate and the application of manganese nicotinate in animal feed. Background technique

[0002] Manganese is a component of arginase, prolinase, RNA polymerase, manganese-containing superoxide dismutase (Mn-SOD), pyruvate carboxylase, etc. Activator of enzymes, transferases, and hydrolases. The absence of manganese in animals results in decreased feed intake, slower growth, lower feed utilization, bone abnormalities, ataxia, and reproductive dysfunction.

[0003] Niacin is 3-picolinic acid, also known as nicotinic acid. It is a vitamin with the simplest structure and the most stable physical and chemical properties. It is an indispensable nutrient in humans and animals. The function of cell metabolism and expansion of blood vessels can promote the growth and development of human and animals, and is an indispensable food and fee...

Examples

Embodiment 1

[0045] A preparation method of manganese nicotinate of the present invention is prepared through the following steps:

[0046] at 2m 3 Add 1 t of water to the reactor, add 100kg of nicotinic acid to the water, add 68kg of manganese sulfate monohydrate after heating to 65°C, cover the reactor and stir the reaction for 2.5h, and use sodium hydroxide solution to control the pH value to 5.5 throughout the process , after making it fully reacted, cooled, and centrifuged again, the solid product obtained after centrifugation was washed 3 times, and after flash drying, 123.5 kg of manganese nicotinate product was obtained.

[0047] The filtered mother liquor contains residual nicotinic acid and manganese nicotinate, which is recycled for use in the next batch of reactions; the number of cycles of recycling is 3 to 5 times.

[0048] After detection and analysis, the Mn in the product manganese nicotinate 2+ The mass content is 16.3%, the mass content of niacin ligand is 72.1%, n(C:H...

Embodiment 2

[0059] A preparation method of manganese nicotinate of the present invention is prepared through the following steps:

[0060] at 5m 3 Add 1.8t of water to the reaction kettle of 222kg of niacin, add 36L of isopropanol, heat up to 83°C, add 169kg of manganese sulfate monohydrate, stir for 0.5h, and use sodium hydroxide solution to control the pH value to 6.0, after making it fully reacted, cooling, and then filter-pressing, washing the product obtained after filter-pressing 3 times, drying at 105°C in a drying room and pulverizing to obtain 324.7kg of manganese nicotinate product.

[0061] The filtered mother liquor contains residual nicotinic acid and manganese nicotinate, which is recycled for use in the next batch of reactions; the number of cycles of recycling is 3 to 5 times.

[0062] After detection and analysis, the Mn in the product manganese nicotinate 2+ The mass content is 16.1%, the mass content of niacin ligand is 71.4%, n(C:H:N)≈6:6:1, the water loss rate of th...

Embodiment 3

[0073] A preparation method of manganese nicotinate of the present invention is prepared through the following steps:

[0074] at 5m 3 0.88t of water was added to the reaction kettle of 1, 220kg of niacin was added to the water, the temperature was raised to 30°C, 88L of isopropanol was added, 58kg of manganese oxide was added, the reaction was stirred for 1.5h, and the pH value was controlled to 6.5 with sodium hydroxide solution throughout the process. , after making it fully reacted, cooled, and centrifuged again, the product obtained after centrifugation was washed 3 times, and after flash drying, 271.0 kg of manganese nicotinate product was obtained.

[0075] The filtered mother liquor contains residual nicotinic acid and manganese nicotinate, which is recycled for use in the next batch of reactions; the number of cycles of recycling is 3 to 5 times.

[0076] After detection and analysis, the Mn in the product manganese nicotinate 2+ The mass content is 16.1%, the mass ...

technical field

[0001] The invention belongs to the field of preparation of feed additives, in particular to a preparation method of manganese nicotinate and the application of manganese nicotinate in animal feed. Background technique

[0002] Manganese is a component of arginase, prolinase, RNA polymerase, manganese-containing superoxide dismutase (Mn-SOD), pyruvate carboxylase, etc. Activator of enzymes, transferases, and hydrolases. The absence of manganese in animals results in decreased feed intake, slower growth, lower feed utilization, bone abnormalities, ataxia, and reproductive dysfunction.

[0003] Niacin is 3-picolinic acid, also known as nicotinic acid. It is a vitamin with the simplest structure and the most stable physical and chemical properties. It is an indispensable nutrient in humans and animals. The function of cell metabolism and expansion of blood vessels can promote the growth and development of human and animals, and is an indispensable food and fee...

Examples

Embodiment 1

[0045] A preparation method of manganese nicotinate of the present invention is prepared through the following steps:

[0046] at 2m 3 Add 1 t of water to the reactor, add 100kg of nicotinic acid to the water, add 68kg of manganese sulfate monohydrate after heating to 65°C, cover the reactor and stir the reaction for 2.5h, and use sodium hydroxide solution to control the pH value to 5.5 throughout the process , after making it fully reacted, cooled, and centrifuged again, the solid product obtained after centrifugation was washed 3 times, and after flash drying, 123.5 kg of manganese nicotinate product was obtained.

[0047] The filtered mother liquor contains residual nicotinic acid and manganese nicotinate, which is recycled for use in the next batch of reactions; the number of cycles of recycling is 3 to 5 times.

[0048] After detection and analysis, the Mn in the product manganese nicotinate 2+ The mass content is 16.3%, the mass content of niacin ligand is 72.1%, n(C:H...

Embodiment 2

[0059] A preparation method of manganese nicotinate of the present invention is prepared through the following steps:

[0060] at 5m 3 Add 1.8t of water to the reaction kettle of 222kg of niacin, add 36L of isopropanol, heat up to 83°C, add 169kg of manganese sulfate monohydrate, stir for 0.5h, and use sodium hydroxide solution to control the pH value to 6.0, after making it fully reacted, cooling, and then filter-pressing, washing the product obtained after filter-pressing 3 times, drying at 105°C in a drying room and pulverizing to obtain 324.7kg of manganese nicotinate product.

[0061] The filtered mother liquor contains residual nicotinic acid and manganese nicotinate, which is recycled for use in the next batch of reactions; the number of cycles of recycling is 3 to 5 times.

[0062] After detection and analysis, the Mn in the product manganese nicotinate 2+ The mass content is 16.1%, the mass content of niacin ligand is 71.4%, n(C:H:N)≈6:6:1, the water loss rate of th...

Embodiment 3

[0073] A preparation method of manganese nicotinate of the present invention is prepared through the following steps:

[0074] at 5m 3 0.88t of water was added to the reaction kettle of 1, 220kg of niacin was added to the water, the temperature was raised to 30°C, 88L of isopropanol was added, 58kg of manganese oxide was added, the reaction was stirred for 1.5h, and the pH value was controlled to 6.5 with sodium hydroxide solution throughout the process. , after making it fully reacted, cooled, and centrifuged again, the product obtained after centrifugation was washed 3 times, and after flash drying, 271.0 kg of manganese nicotinate product was obtained.

[0075] The filtered mother liquor contains residual nicotinic acid and manganese nicotinate, which is recycled for use in the next batch of reactions; the number of cycles of recycling is 3 to 5 times.

[0076] After detection and analysis, the Mn in the product manganese nicotinate 2+ The mass content is 16.1%, the mass ...

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