Method for detecting residual roxithromycin in animal hair
A technology of roxithromycin and animal hair, applied in the field of detection of roxithromycin residues in animal hair, can solve the problem of unreliable detection results of roxithromycin, unfavorable safety supervision of livestock and poultry products, and difficulty in obtaining test samples, etc. problems, achieve the effect of shortening hydrolysis time, saving pretreatment time, and mild hydrolysis extraction conditions
Inactive Publication Date: 2019-01-04
INST OF AGRI PROD QUALITY SAFETY & STANDARD JIANGXI ACAD OF AGRI SCI
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Problems solved by technology
[0005] Therefore, the technical problem to be solved in the present invention is to overcome the unreliable detection results of roxithromycin in livestock and poultry products in the prior art, which is not conducive to the safety supervision of livestock and poultry products, and the detection samples are not easy to obtain or difficult to preserve. Determination method of roxithromycin residue in animal hair
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[0047] 1. Instruments and equipment
[0048] Equipment: University liquid chromatography-tandem mass spectrometer: equipped with electrospray ion source, high-speed centrifuge, nitrogen blowing instrument, analytical balance (0.1mg), ultrasonic generator, etc.
[0049] Standards and reagents: roxithromycin standard: purity >98.5%; internal standard: roxithromycin-D7; methanol and dithiothreitol: chromatographically pure; other reagents are analytically pure, and the experimental water is secondary water .
[0050] Preparation of standard solution: Accurately weigh an appropriate amount of standard roxithromycin and roxithromycin-D7, dissolve in methanol to make a 100.0-1000.0 mg / L standard solution.
[0051]Preparation of standard stock solution: Pipette an appropriate amount of standard solution into a 10.0mL volumetric flask, dilute to the mark with methanol, and prepare a 1.0mg / L standard stock solution.
[0052] Preparation of standard working solution: Properly dilute t...
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Abstract
The invention belongs to the technical field of drug residue detection, in particular to a method for detecting residual roxithromycin in animal hair. The method has the advantages that the animal hair is used as the detection object, livestock and poultry such as chickens, pigs and cattle do not need to be killed, and living livestock and poultry detection is achieved; hair samples are easy to obtain as compared with muscles, livers, excrement and the like, whether roxithromycin is used in the growth process of the livestock and poultry can be accurately monitored due to the fact that the hair is long in growth cycle, and accordingly safety production monitoring of food such the livestock and poultry is achieved; in addition, the method is accurate in detection result, capable of avoidingfalse positive, false negative and the like and high in sensitivity.
Description
technical field [0001] The invention belongs to the technical field of drug residue detection, and in particular relates to a detection method for roxithromycin residue in animal hair. Background technique [0002] Roxithromycin is the second generation of semi-synthetic macrolides as antibiotics. It mainly inhibits the synthesis of bacterial proteins to play a bactericidal effect. It has a wide antibacterial spectrum, fast onset, and strong bactericidal power. Moderately stable and widely distributed in the body, with high and long-lasting tissue concentration and cell concentration, and good curative effect. It is mainly used for respiratory infections of livestock and poultry, such as swine pneumonia, panting disease, influenza, chicken slow breathing, etc., or secondary infections caused by throat, branch, and nose transmission. In addition, roxithromycin also has a good effect on intestinal diseases. [0003] However, the illegal use of roxithromycin in livestock and ...
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Login to View More IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 廖且根袁丽娟张大文向建军罗林广
Owner INST OF AGRI PROD QUALITY SAFETY & STANDARD JIANGXI ACAD OF AGRI SCI