Centrifugal microfluidic chip for rapid detection of trace substances

Abstract

The invention relates to a centrifugal microfluidic chip for rapid detection of trace substances. The centrifugal microfluidic chip comprises a sample inlet 1, a sample inlet 2, a sample inlet 3, a clamping slot 1, a reaction tank, a reaction channel, a detection tank, a vent hole, a waste liquid tank, a clamping slot 2, a clamping slot 3 and a clamping slot 4. The sample inlets 1, 2 and 3 are close to the center of the circle. The detection tank, the vent hole and the waste liquid tank are connected to form a U-shaped structure close to the chip edge. The sample inlets 1, 2 and 3 are orderlyconnected to the reaction tank, the reaction channel, the detection tank, the vent hole and the waste liquid tank. The reaction channel is composed of four V-shaped structures. The outer walls at twosides of the channel are provided with inner raised parts. The clamping slot 1 is located at the center of the circle. The clamping slots 2, 3 and 4 are distributed at three peaks of the equilateral triangle using the center of the circle as a center. The centrifugal microfluidic chip realizes high-flux multi-channel detection of trace substances while fully mixing and reacting various reagents and can ensure high-speed and stable rotation of the microfluidic chip.

Description

technical field [0001] The invention belongs to the field of microfluidics, in particular to a centrifugal microfluidics chip for rapid detection of trace substances. Background technique [0002] In modern life, the detection of trace substances plays an important role in the food industry, environmental monitoring, medical care, and disease diagnosis. Commonly used detection methods include spectrophotometry, gas chromatography, etc., among which spectrophotometry The detection accuracy is low, and usually only qualitative measurement can be achieved; gas chromatography has disadvantages such as high cost of use and small scope of application. Microfluidic chip is a technology that integrates the basic operation units of sample preparation, reaction, separation, and detection in the process of biological, chemical, and medical analysis into a micron-scale chip, and automatically completes the entire analysis process. As a micro-analysis experimental device, the microfluid...

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Problems solved by technology

For example, the patent application number is 201820087187.7, and the patent name is a utility model patent for a microfluidic disk based on the combination of Y-type and S-type channels. The chip has few detection units and cannot achieve high-throughput detection; the patent application number is 201610045231.3, The patent name is the invention patent of microfluidic chip and its application in pesticide detection. The structure of the reaction channel of the chip is simple, which will lead to insufficient reagent reaction; for example, the patent application number is 201620365855.9, and the patent name is a compound centrifugal food A utility model patent for a microfluidic chip for additive detection, which has a small and only one card slot, and has the disadvantage of high-speed centrifugation instability

At present, microfluidic chips used in the field of trace substance detection generally have the problems of simple channel structure and unstable high-speed rotation.

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