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Blood pressure lowering application of furancoumarin in cancura

A technology of furocoumarin and cankula, applied in the field of natural medicinal chemistry, can solve the problems of unreported pharmacological activity, and achieve the effects of significant vasodilation, safe drug selection, and high safety.

Inactive Publication Date: 2019-01-15
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few studies on the chemical constituents of Cankula, and almost no reports on its pharmacological activity

Method used

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  • Blood pressure lowering application of furancoumarin in cancura
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  • Blood pressure lowering application of furancoumarin in cancura

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0050] 1. Preparation and Identification of Angular Furanocoumarins in Kankura

[0051] The E medicine Kankura used in the present invention is collected in the Daxinganling area of ​​Heilongjiang Province, and identified as Heracleum dissectum Ledeb.

Embodiment 1

[0052] Example 1, the separation and purification of isobergamotide in Kankura

[0053] 1) Take the dried roots of Kankura, cut them into 2-3cm segments, soak in industrial methanol for 24 hours, heat and reflux for extraction three times, each time for 3 hours, combine the extracts and recover the solvent under reduced pressure to obtain the total extract. After the total extract is dispersed with an appropriate amount of water, it is extracted 3-5 times with chloroform, the extracts are combined, and the solvent is recovered under reduced pressure to obtain the chloroform extraction part of Kankura.

[0054] 2) 81.8 g of samples from Kankura chloroform extraction site were mixed in 100-200 mesh column chromatography silica gel, packed by wet method, and chloroform-methanol (1:0-0:1) gradient elution. Coumarin compounds can be seen as blue or blue-green fluorescence under ultraviolet light, and the color will change under 365nm of ultraviolet detector after being developed by...

Embodiment 2

[0062] Example 2, Separation and Purification of 6-Methoxy Angelica in Kankura

[0063] 1) Take the dried roots of Kankura, cut them into 2-3cm segments, soak in industrial methanol for 24 hours, heat and reflux for extraction three times, each time for 3 hours, combine the extracts and recover the solvent under reduced pressure to obtain the total extract. After the total extract is dispersed with an appropriate amount of water, it is extracted 3-5 times with chloroform, the extracts are combined, and the solvent is recovered under reduced pressure to obtain the chloroform extraction part of Kankura.

[0064] 2) 81.8 g of samples from Kankura chloroform extraction site were mixed in 100-200 mesh column chromatography silica gel, packed by wet method, and chloroform-methanol (1:0-0:1) gradient elution. Thin-layer chromatography identified 30 fractions after merging the same fractions.

[0065] 3) Fraction 16 was repeatedly passed through the Sephadex LH-20 column, the elution...

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Abstract

The invention discloses a blood pressure lowering application of furancoumarin in cancura, belonging to the fields of natural medicine chemistry and biomedicine. The furanocoumarin has a significant vasodilating effect, and can be used for preparing antihypertensive drugs and / or health products. The furancoumarin compound can be prepared into any pharmaceutically acceptable preparation. The invention opens up a new medical application of the furanocoumarin compound, has the characteristics of strong pharmacological action and high safety, and provides a new, effective and safe drug selection for the cardiovascular patients.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, and in particular relates to horn-type furanocoumarin in cankula, an extraction method thereof and blood pressure lowering application. Background technique [0002] Hypertension is a chronic disease characterized by continuous increase in arterial blood pressure. It is the chief culprit of cardiovascular and cerebrovascular diseases, and can cause a series of cardiovascular and cerebrovascular diseases such as cerebral infarction, cerebral hemorrhage, angina pectoris, and myocardial infarction. disease. What's more, high blood pressure can invade the kidneys, causing patients to suffer from renal insufficiency, and clinically, symptoms such as lower limb edema will appear. [0003] At present, the existing chemical drugs have the disadvantages of single antihypertensive mechanism, large toxic and side effects, and high price, while natural herbal medicines have the advantages of wide ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61P9/12A61P9/00
CPCA61K31/37A61P9/00A61P9/12
Inventor 张海龙张昌龙高阳
Owner XI AN JIAOTONG UNIV
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