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Cordyceps bassiana extract and preparation method

A technology of Cordyceps coccidioides and extracts, which is applied in the field of Cordyceps coccidioides extracts and its preparation, can solve problems such as adverse reactions and side effects, and achieve the effect of simple preparation method and broad application prospects

Active Publication Date: 2019-01-18
XUZHOU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most widely used anti-ulcer western medicines are mainly ranitidine, omeprazole and other drugs. Although the short-term curative effect of western medicine is obvious, there are adverse reactions and side effects after taking the medicine.

Method used

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  • Cordyceps bassiana extract and preparation method
  • Cordyceps bassiana extract and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Using Cordyceps sporocarpus fruiting bodies as raw materials, drying the raw materials to a water content of 18%, and then performing vacuum low-temperature puffing treatment, the conditions of the vacuum low-temperature puffing treatment are: puffing temperature 45°C; vacuum pumping times of 8 times, the puffing time is 1.5 hours.

[0028] (2) Adding a volume concentration of 75% ethanol solution to the Cordyceps coccidioides raw material after vacuum low-temperature puffing treatment, extracting 3 times at 65°C, each time for 1.5h, the addition of each extraction ethanol solution is vacuum low-temperature puffing treatment 6 times of the final Cordyceps coccidioides raw material weight, the liquid that extracts obtains the total extract of ethanol through concentrating and drying; The amount is 4 times of the total extract weight of ethanol), and each extract is evaporated to dryness to obtain the petroleum ether part extract and the ethyl acetate part extract res...

Embodiment 2

[0030] (1) Using Cordyceps coccidioides fruiting body as raw material, drying the raw material to a water content of 15%, and then performing vacuum low-temperature puffing treatment, the conditions of the vacuum low-temperature puffing treatment are: puffing temperature 40°C; vacuum pumping times of 10 times, the puffing time is 2 hours.

[0031] (2) Adding a volume concentration of 70% ethanol solution to the Cordyceps coccidioides raw material after vacuum low-temperature puffing treatment, extracting 4 times at 60°C, each 2h, the addition of each extraction ethanol solution is after vacuum low-temperature puffing treatment 6 times of the Cordyceps coccidioides raw material weight, the liquid that extracts obtains the total extract of ethanol through concentrated drying; Both are 4 times of the total extract weight of ethanol), and each extract is evaporated to dryness to obtain the petroleum ether part extract and the ethyl acetate part extract respectively, and the petrol...

Embodiment 3

[0033] (1) Using Cordyceps coccidioides fruiting body as raw material, drying the raw material to a water content of 20%, and then performing vacuum low-temperature puffing treatment, the conditions of the vacuum low-temperature puffing treatment are: puffing temperature 50°C; vacuum pumping times of 8 times, the puffing time is 1 hour.

[0034] (2) Adding a volume concentration of 80% ethanol solution to the Cordyceps coccidioides raw material after vacuum low-temperature puffing treatment, extracting 2 times at 70°C, each 1h, the addition of each extraction ethanol solution is after vacuum low-temperature puffing treatment 6 times of the Cordyceps coccidioides raw material weight, the liquid that extracts obtains the total extract of ethanol through concentrated drying; Both are 4 times of the total extract weight of ethanol), and each extract is evaporated to dryness to obtain the petroleum ether part extract and the ethyl acetate part extract respectively, and the petroleu...

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Abstract

The invention relates to a Cordyceps bassiana extract and a preparation method thereof. The preparation method comprises the following steps: (1) drying the raw material of Cordyceps sphaerocephala until the water content is 15-20%, and then carry out vacuum low-temperature expansion treatment; (2) adding ethanol solution into the raw material of Cordyceps bassiana after vacuum and low-temperatureexpansion treatment, heating and extracting, and concentrating and drying the extracted liquid to obtain ethanol total extract; A Cordyceps bassiana extract is obtain by dispersing total ethanol extract in water, sequentially extracting with petroleum ether and ethyl acetate, drying solvent of each extracting solution to obtain petroleum ether extract and ethyl acetate extract respectively, and mixing that petroleum ether extract and ethyl acetate extract to obtain Cordyceps bassiana extract. The Cordyceps bassiana extract prepared by the invention can be used as a proton pump inhibitor for preparing a medicine for treating gastric ulcer.

Description

technical field [0001] The invention relates to the technical field of active ingredient extraction, in particular to an extract of Cordyceps coccidioides and a preparation method thereof. Background technique [0002] Cordyceps bassiana was discovered in Anhui in 2000 by the Entomogenous Fungus Research Center of Anhui Agricultural University and reported for the first time in the world. The anamorph of Cordyceps coccidioides is the most widely distributed and most important entomogenous fungus in the world - Beauveria bassiana. Wild Cordyceps coccidioides is obtained from hosts infected with Beauveria bassiana, and belongs to the type-type generation of Beauveria bassiana. [0003] As a kind of medicinal fungus, Cordyceps sinensis is a kind of medicinal fungus, and its active ingredients have always been a hot topic of concern. At present, the research on the active ingredients of Cordyceps sinensis mainly focuses on Cordyceps sinensis and Cordyceps militaris, and there a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61P1/04
CPCA61K36/068A61K2236/333A61K2236/39A61K2236/51A61P1/04
Inventor 邵颖陈安徽刘恩岐张建萍巫永华张爱文
Owner XUZHOU UNIV OF TECH