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Fluorescent probe compound for detecting polysulfide and preparation method thereof

A polysulfide and fluorescent probe technology, applied in chemical instruments and methods, fluorescence/phosphorescence, luminescent materials, etc., can solve the problems of complex operation methods and large instruments, and achieve good selectivity, simple detection operation, and high sensitivity Effect

Active Publication Date: 2019-01-18
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the detection method requires sample pretreatment, complex operation methods and large instruments

Method used

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  • Fluorescent probe compound for detecting polysulfide and preparation method thereof
  • Fluorescent probe compound for detecting polysulfide and preparation method thereof
  • Fluorescent probe compound for detecting polysulfide and preparation method thereof

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Embodiment 1

[0034] A method for preparing a fluorescent probe compound (as shown in formula I) for polysulfide detection, the steps comprising:

[0035]

[0036] Formula I

[0037] (1) Preparation of Compound 1

[0038] 6-Bromo-2-naphthol (10g, 0.0426mol) was dissolved in 40ml of water, and methylamine hydrochloride (15g , 0.222mol) at 140°C for 96 hours. The reaction was cooled to room temperature, washed with aqueous sodium hydroxide solution (2mol / L), dried and recrystallized with methanol to obtain a brown-yellow product with a yield of 83.2%.

[0039] Compound one: 1 H NMR (500 MHz, CDCl 3 -D 1 ) δ (ppm): 2.84 (s, 3H), 3.79 (s,1H), 6.660-6.682 (d, 1H), 6.775-6.910 (q, 1H), 7.635-7.400 (q, 1H), 7.430-7.465 (d, 2H), 7.760-7.790 (d, 1H). 13 C NMR (125 MHz, CDCl 3 -D 1 ) δ (ppm): 147.28, 133.84, 129.65, 129.48, 128.53, 127.98, 127.69, 118.83, 114.98, 103.56, 30.68.

[0040]

[0041] compound one

[0042] (2) Preparation of Compound 2

[0043] Compound 1 (2g, 8.5mmol) wa...

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Abstract

The invention relates to a fluorescent probe compound for detecting polysulfide and a preparation method of the fluorescent probe compound. The structure of the compound is as shown in a formula I. Compared with a traditional detection technique, a non-invasive fluorescent probe is easy, convenient and rapid to operate in detection, high in sensitivity, good in selectivity and short in response time, can conduct in situ and real-time monitoring on a to-be-detected target, and has wide application range. (The formula I is shown in the description).

Description

technical field [0001] The invention belongs to the field of higher organic synthesis, and in particular relates to a fluorescent probe compound for detecting polysulfides and a preparation method thereof. Background technique [0002] Polysulfides are formed by the covalent attachment of mercapto groups to elemental sulfur (or sulfane sulfur). Polysulfides are mainly used as sulfur donors, regulate cell signaling and activate or inhibit enzyme activity. Polysulfides can provide sulfur for cofactors. Polysulfides can also regulate intracellular redox balance by increasing the concentration of reducing active species. For example, supersulfurized cysteine, as the main derivative of cysteine, is a direct and effective antioxidant in cells. At first, polysulfides were thought to be formed by the modification of cysteine ​​by hydrogen sulfide. But hydrogen sulfide and cysteine ​​cannot react directly without the participation of oxidizing agents or enzymes. Recent studies s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D209/14C09K11/06G01N21/64
CPCC07D209/14C09K11/06C09K2211/1029G01N21/6486
Inventor 陈令新王悦张良伟
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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