Quality detection method for concentrated pill for promoting coronary circulation

Abstract

The invention provides a quality detection method for a concentrated pill for promoting coronary circulation. The quality detection method for the concentrated pill for promoting coronary circulationcomprises the steps of the identification and content measurement of the following effective ingredients. The step of identification comprises the following steps that: firstly, taking the concentrated pill for promoting coronary circulation to prepare the solution of a sample for testing; then, taking muscone, borneol, cinobufagin venom toad, bear gall and radix ginseng reference substances to prepare reference substance solution; according to thin layer chromatography, carrying out a test; and in the chromatography of the sample for testing, on a position corresponding to reference substancechromatography, developing fluorescence spots with the same color. The step of content measurement comprises the following steps that: carrying out measurement according to efficient liquid chromatography, wherein each 1g of concentrated pill for promoting coronary circulation contains at least 5.5mg of in vitro breeding bezoar by measuring by bilirubin (C33H36N4O6); each 1g contains at least 1.8mg of cinobufagin venom toad by measuring according to the total amount of cinobufagin (C26H34O6) and resibufogenin (C24H32O4); measuring according to gas chromatography, wherein each 1g of concentrated pill for promoting coronary circulation contains at least 1.0mg of artificial moschus by measuring muscone (C16H30O), and each 1g contains at least 13.5mg of borneol by measuring according to the total amount of isoborneol (C10H18O) and borneol (C10H18O).

Description

technical field [0001] The invention belongs to the field of drug testing, in particular to a quality testing method for concentrated Huoxin pills. Background technique [0002] Huoxin Pill is a 2010 national drug standard improvement product, produced by Guangzhou Yuekang Biopharmaceutical Co., Ltd. [0003] Concentrated Huoxin Pills have the effects of nourishing qi and activating blood circulation, warming the meridians and dredging the meridians. Indications of chest obstruction, heart pain, suitable for coronary heart disease, angina pectoris. [0004] Concentrated Huoxin Pills are black or golden-yellow coated concentrated water pills, brown to dark brown after removing the coating; fragrant, pungent and numb. [0005] The prescription is: Ganoderma lucidum 20g, artificial musk 1.2g, bear bile 2.4g, in vitro cultured bezoar 1.2g, pearl 2.4g, ginseng 18g, toad venom 1.8g, aconite (Heishun slice) 9g, borneol 1.2g, safflower 2.0g. [0006] The preparation method is: th...

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Problems solved by technology

[0008] The purpose of the present invention is to provide a quality detection method for concentrated Huoxin pills, which solves the problem of one-sidedness and insufficient comprehensiveness in the existing quality standard detection of concentrated Huoxin pills, and realizes comprehensive and effective control of the quality of the product

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