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Quality detection method for concentrated pill for promoting coronary circulation

A quality inspection method and technology for Huoxin Pills, which can be applied to measurement devices, instruments, scientific instruments, etc., and can solve the problems of insufficient comprehensiveness and one-sidedness of concentrated Huoxin Pills.

Active Publication Date: 2019-01-18
GUANGZHOU RUIKANG BIOLOGICAL PHARMA
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  • Abstract
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  • Claims
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Problems solved by technology

[0008] The purpose of the present invention is to provide a quality detection method for concentrated Huoxin pills, which solves the problem of one-sidedness and insufficient comprehensiveness in the existing quality standard detection of concentrated Huoxin pills, and realizes comprehensive and effective control of the quality of the product

Method used

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  • Quality detection method for concentrated pill for promoting coronary circulation
  • Quality detection method for concentrated pill for promoting coronary circulation
  • Quality detection method for concentrated pill for promoting coronary circulation

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Experimental program
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Embodiment Construction

[0044] The quality detection method of described concentrated heart pill comprises following identification method and assay method:

[0045] (1) Identification method

[0046] 1. TLC identification of muscone

[0047] ①Materials and reagents: Merck silica gel G thin-layer plates. All other reagents were analytically pure.

[0048] ②Reference substance: Muscone reference substance, batch number 110719-201014, purchased from China Inspection Institute.

[0049] ③ Test product: Concentrated Huoxin Pills with batch numbers 12030201, 12050101, 12060101, 12070101, 12080101, provided by Guangzhou Yuekang Biopharmaceutical Co., Ltd.

[0050] Take 0.8g each of 5 batches of the test sample, grind it finely, add 15ml of ether, ultrasonic treatment for 15 minutes, filter, filter the residue for later use, evaporate the filtrate, add 1ml of ethanol to the residue to dissolve, and use it as the test solution; For the reference substance, add ethanol to make a solution containing 1mg pe...

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Abstract

The invention provides a quality detection method for a concentrated pill for promoting coronary circulation. The quality detection method for the concentrated pill for promoting coronary circulationcomprises the steps of the identification and content measurement of the following effective ingredients. The step of identification comprises the following steps that: firstly, taking the concentrated pill for promoting coronary circulation to prepare the solution of a sample for testing; then, taking muscone, borneol, cinobufagin venom toad, bear gall and radix ginseng reference substances to prepare reference substance solution; according to thin layer chromatography, carrying out a test; and in the chromatography of the sample for testing, on a position corresponding to reference substancechromatography, developing fluorescence spots with the same color. The step of content measurement comprises the following steps that: carrying out measurement according to efficient liquid chromatography, wherein each 1g of concentrated pill for promoting coronary circulation contains at least 5.5mg of in vitro breeding bezoar by measuring by bilirubin (C33H36N4O6); each 1g contains at least 1.8mg of cinobufagin venom toad by measuring according to the total amount of cinobufagin (C26H34O6) and resibufogenin (C24H32O4); measuring according to gas chromatography, wherein each 1g of concentrated pill for promoting coronary circulation contains at least 1.0mg of artificial moschus by measuring muscone (C16H30O), and each 1g contains at least 13.5mg of borneol by measuring according to the total amount of isoborneol (C10H18O) and borneol (C10H18O).

Description

technical field [0001] The invention belongs to the field of drug testing, in particular to a quality testing method for concentrated Huoxin pills. Background technique [0002] Huoxin Pill is a 2010 national drug standard improvement product, produced by Guangzhou Yuekang Biopharmaceutical Co., Ltd. [0003] Concentrated Huoxin Pills have the effects of nourishing qi and activating blood circulation, warming the meridians and dredging the meridians. Indications of chest obstruction, heart pain, suitable for coronary heart disease, angina pectoris. [0004] Concentrated Huoxin Pills are black or golden-yellow coated concentrated water pills, brown to dark brown after removing the coating; fragrant, pungent and numb. [0005] The prescription is: Ganoderma lucidum 20g, artificial musk 1.2g, bear bile 2.4g, in vitro cultured bezoar 1.2g, pearl 2.4g, ginseng 18g, toad venom 1.8g, aconite (Heishun slice) 9g, borneol 1.2g, safflower 2.0g. [0006] The preparation method is: th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 上官康
Owner GUANGZHOU RUIKANG BIOLOGICAL PHARMA
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