Equipment and preparation method for preparing lipid microspheres
A technology of lipid microspheres and lecithin, which is applied to the equipment and preparation of lipid microspheres, and the field of preparation of lipid microspheres, which can solve the problems of surface floating oil phase separation and insufficient colostrumization, etc.
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Embodiment 1
[0039] Water phase composition: water 103kg, glycerin 2.65kg; Oil phase composition: alprostadil 0.72g, refined soybean oil 12kg, refined egg yolk lecithin PC-98T 2.16kg, oleic acid 288g; pH regulator: 10% (g / ml ) sodium hydroxide solution to adjust the pH value to 5.2-5.8.
[0040] (1) Water phase preparation: add 80% water for injection into the water phase tank, control the water temperature at 65-75°C, add glycerin under nitrogen filling conditions, stir to dissolve, and set aside;
[0041] (2) Oil phase preparation: under the condition of nitrogen filling in the oil phase tank, heat alprostadil, soybean oil, refined egg yolk lecithin, oleic acid to 60--70°C, shear and stir until the solution is clear;
[0042] (3) Primary emulsification: slowly add the oil phase to the water phase, and emulsify in the water phase tank through the high-speed shear emulsification head for 25-35 minutes, and the high-speed shear emulsification head is set on the tank body through the fixed s...
Embodiment 2
[0044] Raw material composition, step 1, step 2 are identical with embodiment 1.
[0045](3) Primary emulsification: Under the condition of nitrogen filling, the oil phase and the water phase are passed through the three-stage online disperser (with a speed of 2000-3000rpm) according to the volume ratio of 1:4, and then flow back into the water phase tank, and the three-stage online dispersion The machine circulates and shears 3-5 times. After the circular shearing, the liquid is stored in the water phase tank and continues to be emulsified for 25-35 minutes. 2000-3000rpm, add water for injection to the full amount, and add an appropriate amount of 10% (g / ml) sodium hydroxide solution to adjust the pH value of the solution, and stir to obtain colostrum.
Embodiment 3
[0047] Raw material composition, step 1, step 2 are identical with embodiment 1.
[0048] (3) Primary emulsification: Under the condition of nitrogen filling, the oil phase and the water phase are sheared by a three-stage online disperser (rotating speed: 2000-3000rpm) according to the volume ratio of 1:4, and then flowed back into the water phase tank. The online disperser cuts 3-5 times in a cycle; the three-stage online disperser turns on the high-speed shear emulsification head at the same time during the cycle shear process. 2000-3000rpm; the liquid after cyclic shearing is stored in the water phase tank and continues to emulsify for 25-35 minutes, the shearing speed is 2000-3000rpm, add water for injection to the full amount and add an appropriate amount of 10% (g / ml) hydroxide Sodium solution adjusts the pH value of the solution, stirs and mixes to obtain colostrum;
[0049] (4) High-pressure homogenization: the colostrum is subjected to high-pressure homogenization, a...
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Abstract
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