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Method for detecting the content of 6 phenolic acid compounds in salvia miltiorrhiza water-extracting solution and application

An aqueous extraction and phenolic acid technology, applied in the field of detecting the content of 6 phenolic acid compounds in the aqueous extract of Salvia miltiorrhiza, can solve the problems of high requirements for instruments and analysts, a lot of time spent by analysts, and complex analysis operations. To achieve the effect of shortening the measurement time, convenient preprocessing, and simple operation

Inactive Publication Date: 2019-01-25
贵州拜特制药有限公司
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  • Description
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Problems solved by technology

This method has high analytical precision, but requires analysts to spend a lot of time analyzing it. The analysis operation is complicated, the instrument takes a long time, the pretreatment is troublesome, and the requirements for instruments and analysts are high. It is not suitable for real-time analysis and monitoring of the process.

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  • Method for detecting the content of 6 phenolic acid compounds in salvia miltiorrhiza water-extracting solution and application
  • Method for detecting the content of 6 phenolic acid compounds in salvia miltiorrhiza water-extracting solution and application
  • Method for detecting the content of 6 phenolic acid compounds in salvia miltiorrhiza water-extracting solution and application

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Embodiment Construction

[0082] The present invention will be further described below in conjunction with the accompanying drawings and embodiments, but not as a basis for limiting the present invention.

[0083] Example. The method for detecting the content of 6 phenolic acid compounds in the salvia miltiorrhiza root water extract, such as Figure 1 to Figure 16As shown, the water extract of Salvia miltiorrhiza was collected as a calibration set sample, and the near-infrared absorption spectrum data of the calibration set sample was obtained by scanning, and salvianolic acid A, salvianolic acid B, danshensu, rosmarinic acid, The contents of protocatechuic acid and shikonian acid were used as reference values, and the partial least squares method in the multivariate analysis technique was used to establish a calibration model for the relationship between the near-infrared spectrum of the water extract of Danshen and various quality indicators. The near-infrared absorption spectrum data of the extract...

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Abstract

The invention discloses a method for detecting the content of 6 phenolic acid compounds in salvia miltiorrhiza water-extracting solution and application. By adopting the method, the content of corresponding quality index substances is calculated by determining near-infrared spectrum data of a salvia miltiorrhiza water-extracting solution to be determined and utilizing an established correction model. The method is simple in analyzing operation and suitable for real-time analysis and monitoring of the process, the time needed by instruments is short, pretreatment is quick and convenient, the requirements for the instruments and analyzing workers are reduced, the content of danshinolic acid A, danshinolic acid B, tanshinol, rosmarinic acid, protocatechuic acid and alkannic acid in the salviamiltiorrhiza water-extracting solution can be simultaneously and quickly detected, and the method is applied to real-time monitoring of the danshinolic acid A, danshinolic acid B, tanshinol, rosmarinic acid, protocatechuic acid and alkannic acid in a salvia miltiorrhiza water-extracting unit in the production process of salvia miltiorrhiza and chuanxiongzine injection liquid.

Description

technical field [0001] The invention relates to quality monitoring in the production process, in particular to a method and application for detecting the content of six phenolic acid compounds in the salvia miltiorrhiza water extract. Background technique [0002] Salvia miltiorrhiza is the dry root and stem of Salvia miltiorrhiza. Chinese herbal injections have been widely used in the treatment and adjuvant treatment of coronary heart disease, angina pectoris, myocardial infarction, blood stasis pulmonary heart disease, ischemic encephalopathy, cerebral thrombosis and other diseases. According to the theory of traditional Chinese medicine, Salvia miltiorrhiza has the effects of dispelling addiction and relieving pain, promoting blood circulation and promoting menstruation, clearing heart and calming nerves. With the widespread application of Danshen injection, people pay more and more attention to the quality control level of its production process. [0003] The main effe...

Claims

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Application Information

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IPC IPC(8): G01N21/359G01N21/3577G01N21/33G01N30/02
CPCG01N21/33G01N21/3577G01N21/359G01N30/02
Inventor 瞿海斌赵芳陈泽麒薛捷张禄权李白玲
Owner 贵州拜特制药有限公司
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