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Application of Danshexinkun C in preparation of medicines treating hypertensive heart muscle fibrosis

A technique for myocardial fibrosis and anti-hypertension, applied in the field of biomedicine, can solve problems such as unknown active ingredients, and achieve the effects of solving single action pathway, increasing ejection fraction and short-axis shortening rate, and improving cardiac structure and functional damage.

Inactive Publication Date: 2019-02-26
SOUTHERN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, at present, most of the theories and foundations of traditional Chinese medicine have not been scientifically verified by modern western medicine, and many Chinese medicinal materials inevitably have problems such as unknown active ingredients while exerting their effects

Method used

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  • Application of Danshexinkun C in preparation of medicines treating hypertensive heart muscle fibrosis
  • Application of Danshexinkun C in preparation of medicines treating hypertensive heart muscle fibrosis
  • Application of Danshexinkun C in preparation of medicines treating hypertensive heart muscle fibrosis

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Embodiment Construction

[0022] The present invention will be further described below in conjunction with specific tests. It should be understood that the following tests are only used to illustrate the present invention and are not intended to limit the protection scope of the present invention.

[0023] 1. Preparation of drug solution:

[0024] Preparation of Salvia quinone C solution: Precisely weigh 250 mg, 500 mg, 1000 mg of pure Danshenxin quinone C (purchased from Shanghai Lianshuo Biotechnology Co., Ltd., item number AB7447), add 0.9% normal saline to dissolve and make to volume to 100mL to obtain 2.5mg / mL, 5mg / mL, and 10mg / mL solutions, and store them in a refrigerator at 4°C in the dark for later use.

[0025] Configuration of valsartan solution: ready-to-use, use a mortar to grind valsartan tablets into powder, accurately weigh 150mg, add 0.9% normal saline to dissolve and dilute to 100mL to obtain 1.5mg / mL of valsartan solution, protected from light and stored in a refrigerator at 4°C. ...

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Abstract

The invention discloses application of Danshexinkun C or pharmacologically acceptable salts thereof in preparation of medicines and / or healthcare products treating hypertension and / or heart diseases.The Danshexinkun C can reduce collagen deposition in cardiac muscle, and increase heart EF and FS while reducing blood pressure, and can effectively improve heart structural and function damage causedby hypertension. Problems that present hypotensive drugs have single action routes and large side effects can be solved, and the basis for further mechanism research of the Danshexinkun C in hypertensive heart muscle fibrosis intervening is provided.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of salvianolic quinone C in the preparation of antihypertensive myocardial fibrosis drugs. Background technique [0002] Myocardial fibrosis refers to the massive deposition of collagen fibers in the interstitium of myocardial tissue or the collagen volume fraction is significantly higher than normal. Studies have shown that in the process of hypertension, the compliance of myocardial tissue will be reduced, and myocardial activity will be inhibited, thereby affecting the systolic and diastolic functions of the heart, which is an important cause of heart failure. Studies in recent years have found that the above-mentioned complications of hypertension are closely related to the excessive deposition of myocardial fiber collagen, that is, myocardial fibrosis. Therefore, research on improving and reversing myocardial fibrosis is of great significance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P9/12A61P9/00A23L33/105
CPCA61K31/122A23L33/105A23V2002/00A61P9/00A61P9/12A23V2200/326A23V2250/21
Inventor 吕琳张国华吴少瑜陈凯黄裕刘馨庄宇鑫全东令马韵词张静茹
Owner SOUTHERN MEDICAL UNIVERSITY
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