Application of ICTF (trifluoro-icaritin) to preparation of drug for activating Akt signals and inhibiting autophagy

A technology of epimedium trifluoride and signal inhibition, applied in the field of medicine, can solve the problems of myocardial dysfunction, impaired cardiac function, myocardial cell damage and the like

Active Publication Date: 2019-02-26
GANNAN MEDICAL UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

The treatment of ischemic myocardial tissue to get blood supply again often leads to reperfusion injury to varying degrees, with obvious myocardial dysfunction and structural damage
This phenomenon of tissue damage aggravated or even irreversible damage after blood supply is restored on the basis of myocardial ischemia is called myocardial ischemia / reperfusion injury, which reduces the effect of reperfusion therapy, resulting in impaired cardiac function and myocardial infarction. Cell damage, etc., has seriously affected the prognosis of basic diseases and has become an important issue in clinical cardiology

Method used

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  • Application of ICTF (trifluoro-icaritin) to preparation of drug for activating Akt signals and inhibiting autophagy
  • Application of ICTF (trifluoro-icaritin) to preparation of drug for activating Akt signals and inhibiting autophagy
  • Application of ICTF (trifluoro-icaritin) to preparation of drug for activating Akt signals and inhibiting autophagy

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Experimental program
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Embodiment 1

[0020] (1) In vivo experiment

[0021] 1) Experimental animals: 30 male Sprague-Dawely (SD) rats of SPF grade, weighing 250±20g, all rats had free access to water and diet, and were maintained in a constant temperature and humidity environment of 12h:12h light:dark. Rats were randomly divided into 5 groups

[0022] ① Sham operation control group: sublingual intravenous injection of normal saline;

[0023] ②Myocardial ischemia-reperfusion injury model group: sublingual injection of normal saline;

[0024] ③ Myocardial ischemia-reperfusion injury model + trifluoroicariin low-dose group: intraperitoneal injection of 0.5 mg / ml trifluoroicariin;

[0025] ④ Myocardial ischemia-reperfusion injury model + trifluoroicariin medium dose group: intraperitoneal intravenous injection of 1.0 mg / ml trifluoroicariin;

[0026] ⑤ Myocardial ischemia-reperfusion injury model + trifluoroicariin high-dose group: intraperitoneal intravenous injection of 2.0 mg / ml trifluoroicariin;

[0027] 2) Pr...

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Abstract

The invention discloses an application of ICTF (trifluoro-icaritin) to preparation of a drug for activating Akt signals and inhibiting autophagy. When ICTF is applied to a drug for treating cardiovascular diseases, it is proved that ICTF can relieve ischemia reperfusion-induced EGG damage, reduce myocardial oxidative stress of ischemia reperfusion injury, inhibit autophagy and apoptosis of myocardial cells, improve activation of the Akt signals and reduce levels of autophagy markers Beclin-1 and LC3-II. The drug for treating the cardiovascular diseases has development prospect and is especially used for treating myocardial ischemia (myocardial infarction) reperfusion injury.

Description

Technical field: [0001] The invention belongs to the field of medicine, and specifically relates to the application of trifluoroicariin in the preparation of drugs for activating Akt signal and inhibition of autophagy and the application of trifluoroicariin in the preparation of drugs for inhibiting apoptosis. Background technique: [0002] With the continuous development of our country's economy and the continuous improvement of people's living standards, the incidence of cardiovascular system diseases in our country has been increasing, and it has become one of the main causes of death in our country. Among them, ischemic cardiomyopathy has become the first Cause of death. The treatment of ischemic myocardial tissue to get blood supply again often leads to reperfusion injury to varying degrees, and obvious myocardial dysfunction and structural damage. This phenomenon of tissue damage aggravated or even irreversible damage after blood supply is restored on the basis of myo...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P9/10
CPCA61K31/352A61P9/10
Inventor 黄志华黎晓李良东刘瑞珍薛进华黄诚
Owner GANNAN MEDICAL UNIV
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