Eye drops containing exosomes for dry eye treatment and preparation method thereof

Abstract

The invention provides eye drops containing exosomes for dry eye treatment and a preparation method thereof. The eye drops are prepared from the following components: 2.5% of exosomes, an auxiliary ingredient and the balance water for injection, wherein the total content of the raw materials is 100%, the auxiliary ingredient is prepared from the following components in percentage by mass: 0.2% ofvitamin E, 0.2% of carbomer and 2% of an osmotic pressure regulator, the exosomes are extracted from human umbilical cord mesenchymal stem cells, the vitamin E can inhibit the reaction of lipid peroxidase in lens of eyes, enable peripheral blood vessels top be expanded and improve blood circulation, the carbomer enables the eye drops to achieve proper viscosity, and the osmotic pressure regulatoris NaCl. The method comprises the following steps of extracting the exosomes in a gradient centrifugation method, preparing a sealed container, preparing the auxiliary ingredient, and finally carryingout split packaging to obtain a sterile preparation convenient to use so as to safely and effectively treat dry eyes.

Description

technical field [0001] The invention belongs to the technical field of eye drops for treating dry eye, and in particular relates to an eye drop containing exosomes for dry eye treatment and a preparation method thereof. technical background [0002] Dry eye is a common and frequently-occurring disease in ophthalmology clinics. According to the large sample dry eye epidemiological survey conducted in the United States by Schaumberg et al.: the prevalence of dry eye in women under the age of 50 is 5.7%, and the prevalence rate rises to 9.8% after the age of 75, and the dry eye of women Symptoms are more obvious than men, and the higher the education level, the higher the prevalence rate; similarly, the prevalence rate of dry eye in men aged 50-54 is 3.9%, and the prevalence rate increases to 7.67%, it is estimated that by 2030, there will be 2.79 million male dry eye patients in the United States. In my country, according to the epidemiological survey results conducted by Sh...

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Problems solved by technology

[0004] In recent years, although there are eye drops that can increase the moisturizing effect on the market, such as sodium hyaluronate eye drops or eye drops containing sodium hyaluronate, sodium hyaluronate is unstable under light and heat and is easy to degrade. It is not suitable for long-term storage at room temperature. At the same time, sodium hyaluronate is a kind of biological macromolecule mucopolysaccharide, which is easy to be polluted and grow bacteria

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