Eye drops containing exosomes for dry eye treatment and preparation method thereof

A technology for exosomes and eye drops, which is applied in the directions of medical preparations containing active ingredients, medical preparations with non-active ingredients, and pharmaceutical formulas, can solve problems that are not suitable for long-term storage, easily contaminated by bacteria, and sodium hyaluronate. Instability and other problems, to achieve the effect of facilitating treatment, reducing systemic toxicity and increasing drug concentration

Pending Publication Date: 2019-03-08
西安市第四医院
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In recent years, although there are eye drops that can increase the moisturizing effect on the market, such as sodium hyaluronate eye drops or eye drops containing sodium hyaluronate, sodium hyaluronate is unstable under light a

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Eye drops containing exosomes for dry eye treatment and preparation method thereof
  • Eye drops containing exosomes for dry eye treatment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The present invention will be clearly and completely described below, so that those skilled in the art can fully implement the present invention without creative efforts.

[0016] The specific embodiment of the present invention is: an eye drop containing exosomes for dry eye treatment, its component content specifically includes: 2.5% exosomes, auxiliary ingredients, the balance is water for injection, the amount of each raw material The total content is 100%, and the auxiliary ingredients include vitamin E, 0.2 carbomer, and 2% osmotic pressure regulator in a total mass fraction of 0.2%, and the exosomes are obtained from human umbilical cord mesenchymal stem cells Extraction, the vitamin E can inhibit the lipid peroxide reaction in the lens of the eye, dilate the peripheral blood vessels, improve blood circulation, the carbomer makes the eye drops reach a suitable viscosity, and the osmotic pressure regulator is NaCl .

[0017] A method for preparing eye drops conta...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides eye drops containing exosomes for dry eye treatment and a preparation method thereof. The eye drops are prepared from the following components: 2.5% of exosomes, an auxiliary ingredient and the balance water for injection, wherein the total content of the raw materials is 100%, the auxiliary ingredient is prepared from the following components in percentage by mass: 0.2% ofvitamin E, 0.2% of carbomer and 2% of an osmotic pressure regulator, the exosomes are extracted from human umbilical cord mesenchymal stem cells, the vitamin E can inhibit the reaction of lipid peroxidase in lens of eyes, enable peripheral blood vessels top be expanded and improve blood circulation, the carbomer enables the eye drops to achieve proper viscosity, and the osmotic pressure regulatoris NaCl. The method comprises the following steps of extracting the exosomes in a gradient centrifugation method, preparing a sealed container, preparing the auxiliary ingredient, and finally carryingout split packaging to obtain a sterile preparation convenient to use so as to safely and effectively treat dry eyes.

Description

technical field [0001] The invention belongs to the technical field of eye drops for treating dry eye, and in particular relates to an eye drop containing exosomes for dry eye treatment and a preparation method thereof. technical background [0002] Dry eye is a common and frequently-occurring disease in ophthalmology clinics. According to the large sample dry eye epidemiological survey conducted in the United States by Schaumberg et al.: the prevalence of dry eye in women under the age of 50 is 5.7%, and the prevalence rate rises to 9.8% after the age of 75, and the dry eye of women Symptoms are more obvious than men, and the higher the education level, the higher the prevalence rate; similarly, the prevalence rate of dry eye in men aged 50-54 is 3.9%, and the prevalence rate increases to 7.67%, it is estimated that by 2030, there will be 2.79 million male dry eye patients in the United States. In my country, according to the epidemiological survey results conducted by Sh...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/08A61K47/22A61K47/32A61K35/28A61P27/02
CPCA61K9/0048A61K9/08A61K35/28A61K47/22A61K47/32A61P27/02
Inventor 李娟龙乾发周颖王甜鲜盼盼邵毅谭钢
Owner 西安市第四医院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap