Preparation method for baicalein drug-loading nanorod

A technology of drug-loading nanometer and baicalein, applied in the directions of nanotechnology, nanotechnology, nanomedicine, etc., to achieve the effect of increased retention, broad application prospects, and prolonged circulation time

Active Publication Date: 2019-03-08
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The oral toxicity of baicalein is extremely low, but its intravenous injection is much more toxic than oral gavage

Method used

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  • Preparation method for baicalein drug-loading nanorod
  • Preparation method for baicalein drug-loading nanorod

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Embodiment 1

[0017] 1. Test plan

[0018] A preparation method of baicalein drug-loaded nanorods, comprising the following steps:

[0019] (1) Weigh 7.957g of sodium dihydrogen phosphate and 17.549g of disodium hydrogen phosphate powder, respectively dissolve them in appropriate amount of distilled water, then transfer them to a 500ml volumetric flask, dilute with distilled water to 500mL, and obtain the pH value Phosphate buffer solution of 6.7;

[0020] (2) Accurately weigh 0.01g of baicalein, add 0.10g of pectin into a 50mL volumetric flask, add a magnet, then add 20mL of PBS solution with a pH of 6.7, and then immerse in a constant temperature water bath at 50°C for magnetic stirring , heating for 0.5 hours; preparation of Ca(OH) 2 solution (0.02mol / L), add 8mL dropwise to the above solution, and stir at 50°C for 1 hour; then, NaHCO 3 8 mL of the solution (0.03 mol / L) was added dropwise to the above reaction system, stirred at 50° C. for another 3 hours, and then 0.010 g of baicalei...

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Abstract

The invention relates to a preparation method for a baicalein drug-loading nanorod, and belongs to the field of pharmacy. The method comprises the following steps that firstly, the baicalein and pectin are weight separately and are added into a glass container, then a phosphate buffer solution is added, the glass container is immersed in a thermostatic water bath at the temperature of 50 DEG C, and magnetic stirring and uniform mixing are carried out so as to obtain a mixed solution I; then a Ca(OH)-water solution is dropwise added into the mixed solution I, and then heating is carried out for1 hour at the temperature of 50 DEG C; then a NaHCO3-water solution is dropwise added, and then heating is carried out for 3 hours at the temperature of 50 DEG C so as to obtain a mixed solution II;and finally, the baicalein is added into the mixed solution II, and magnetic stirring is continuously carried out for 24 hours at the temperature of 50 DEG C, cooling is carried out, then the mixtureis put into a dialysis bag, and dialysis is carried out in the phosphate buffer solution at the temperature of 20 DEG C for 24 hours so as to obtain the baicalein drug-loading nanorod. The baicalein drug-loading nanorod prepared through the preparation method shows good targeting property, histocompatibility, low toxic and side effects and slow-release function.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a preparation method of baicalein drug-loaded nanorods. Background technique [0002] The nano drug-carrying system refers to a complete system in which the prepared nano-structure particle size is between 1 and 1000 nm, and the drug is encapsulated, dispersed, and adsorbed in the polymer. Flavonoids refer to a general term for a class of compounds with a chromone ring and a benzene ring as the basic structure. They are derivatives of chromone or chromane, derived from flavone (2-phenylchromone) as the mother nucleus. A class of yellow pigments. Nano-loaded drug system is a new drug delivery form. The size of drug-loaded nanoparticles is similar to that of body proteins. It can easily penetrate the cell membrane and enter the interstitial fluid without being rejected by the body. It has good tissue compatibility. By encapsulating the drug to achieve sustained release and sta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/52A61K31/352A61K47/36A61P1/16A61P7/10A61P29/00A61P31/04A61P31/12A61P35/00B82Y5/00
CPCA61K9/146A61K9/5161A61K31/352A61P1/16A61P7/10A61P29/00A61P31/04A61P31/12A61P35/00B82Y5/00
Inventor 梁菊吴文澜梁园李军波周惠云
Owner HENAN UNIV OF SCI & TECH
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