Preparation method of 2-chloro-3-isothiocyanato-prop-1-ene

Abstract

The invention discloses apreparation method of 2-chloro-3-isothiocyanato-prop-1-ene. According to the preparation method, the 2-chloro-3-isothiocyanato-prop-1-ene is prepared with 2,3-dichloropropeneand ammonium thiocyanate as reaction raw materials and water as a reaction solvent under the action of a phase transfer catalyst in a microreactor. Compared with a kettle type reactor adopted in the prior art, the microreactor adopted by the method has the advantages of full contact in a two phase reaction, good mass and heat transfer effect, high process controllability, high safety coefficient and the like, the 2-chloro-3-isothiocyanato-prop-1-ene can be prepared efficiently in an environmentally friendly manner at low cost, and high product yield and product content are realized. The preparation method has the advantages of ready availability of raw materials, simple process, easiness and convenience in operation, low cost, high reaction speed, less three wastes (waste gas, waste waterand industrial residue), high product yield, high product content, environmental friendliness and the like, is suitable for industrial production, and has a very good application prospect.

Description

technical field [0001] The invention relates to a preparation method of 2-chloropropenyl isothiocyanate. technical background [0002] 2-Chloropropenyl isothiocyanate is the precursor of 2-chloro-5-chloromethylthiazole, which is a second-generation nicotinic insecticide thiazole pesticide Clothiazole Key intermediates of oxazine and clothianidin. Therefore, it is of great significance to obtain high-quality 2-chloropropenyl isothiocyanate by an efficient and environmentally friendly preparation method for the research on the new process of 2-chloro-5-chloromethylthiazole. [0003] At present, there are many preparation methods of 2-chloroallyl isothiocyanate reported both at home and abroad, such as the Chinese patent literature whose publication number is CN102363605A discloses a kind of preparation method of 2-chloroallyl isothiocyanate, Using water as a solvent, react 2,3-dichloropropene with sodium thiocyanate, and react for 20 hours under the action of a phase transfe...

AI Technical Summary

Problems solved by technology

In this method, although it has advantages such as shorter reaction time and higher yield, its experimental operation is comparatively complicated; Simultaneously this method is greater than the molar charging capacity of 2,3-dichloropropene due to the molar charging capacity of sodium thiocyanate, There are a lot of thiocyanate ions in the wastewater, so this method is also not suitable for green and clean industrial production

[0004] In summary, there are following problems in the existing method for preparing 2-chloropropenyl isothiocyanate: complex process, difficult operation, high production cost, slow reaction speed, large amount of three wastes, easy to cause secondary pollution to the environment, etc.