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Hemostatic composition, and preparation method and application of hemostatic composition

A composition and coagulation technology, applied in application, pharmaceutical formulation, drug delivery, etc., can solve the problems such as subsequent swelling properties of hemostatic composite materials that are not involved, and achieve the effect of avoiding auxiliary tools and increasing gel strength.

Active Publication Date: 2019-03-12
CHENGDU MEDART MEDICAL SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above method uses methacrylic acid-modified grafted gelatin to form a hydrogel with other monomers, it does not involve the subsequent swelling of the hemostatic composite.

Method used

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  • Hemostatic composition, and preparation method and application of hemostatic composition

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preparation example Construction

[0043] The preparation method of the hemostatic composition of the present invention comprises 1) preparation of cross-linked modified gelatin powder; 2) preparation of cross-linked oxidized alginate powder; 3) preparation of hemostatic composition. A detailed description is given below.

[0044] In step 1), 0.1 to 1 part by weight, preferably 0.5 to 0.8 parts by weight of (meth)acrylated gelatin and 0.005 to 0.1 parts by weight, preferably 0.01 to 0.05 parts by weight of β-cyclodextrin and The embedding formed by camphorquinone is added to 0.5-2 parts by weight, preferably 1.6-1.8 parts by weight of phosphate (PBS) buffer solution, and then the wavelength is 420nm-480nm, and the light intensity is 1200-2000mW / cm 2 Irradiate blue light for 3 to 5 minutes to solidify and cross-link to obtain a cross-linked product, remove residual embedded matter, freeze-dry at -80 to -35°C, preferably -60 to -40°C, crush and sieve to obtain granules Cross-linked modified gelatin powder having...

Embodiment 1

[0067] Preparation of methacrylated gelatin:

[0068] Add 10g of gelatin into 100ml of PBS buffer (0.01M), heat up to 50°C to dissolve completely, then slowly add 0.6ml of methacrylic anhydride dropwise, and keep warm for 3 hours after the dropwise addition to form a reaction solution. 400 ml of PBS buffer (0.01M) was added to the reaction solution. The diluted reaction solution was dialyzed with regenerated cellulose membrane ( Molecular weight cut-off 12000 ~ 14000) dialyzed for 5 days, and the purified water was replaced once a day. Using a 0.45 μm microporous filter membrane to filter under reduced pressure and freeze-dry to obtain methacrylic anhydride gelatin.

[0069] Visible photoinitiator:

[0070] Mix β-cyclodextrin, camphorquinone and water at a ratio of 2:1:10 (mass:mass:volume), and ultrasonically induce solubilization to form embeddings; then dry the embeddings under reduced pressure, grind them, and vacuum Dry to obtain a visible photoinitiator.

[0071] P...

Embodiment 2

[0079] Preparation of methacrylated gelatin:

[0080] Add 10g of gelatin into 100ml of PBS buffer (0.01M), raise the temperature to 50°C to dissolve completely, then slowly add 0.8ml of methacrylic anhydride dropwise, and keep warm for 3 hours after the dropwise addition to form a reaction solution. 400 ml of PBS buffer (0.01M) was added to the reaction solution. The diluted reaction solution was dialyzed with regenerated cellulose membrane ( Molecular weight cut-off 12000 ~ 14000) dialyzed for 5 days, and the purified water was replaced once a day. Using a 0.45 μm microporous filter membrane to filter under reduced pressure and freeze-dry to obtain methacrylic anhydride gelatin.

[0081] Visible photoinitiator:

[0082] Mix β-cyclodextrin, camphorquinone and water at a ratio of 2:1:10 (mass:mass:volume), and ultrasonically induce solubilization to form embeddings; then dry the embeddings under reduced pressure, grind them, and vacuum Dry to obtain a visible photoinitiato...

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Abstract

The invention discloses a hemostatic composition, and a preparation method and application of the hemostatic composition. The hemostatic composition is prepared from the following components in partsby weight: 0.5-10 parts of crosslinked modified gelatin powder, 0.05-3 parts of crosslinked oxidized alginate powder and 100-5000 U of a coagulation protein substance. The crosslinked modified gelatinpowder is prepared from (methyl)acrylated gelatin with a (methyl)acrylate group substitution degree being 30-80%, and the oxidation degree of the crosslinked oxidized alginate powder is 20-50%. The invention further discloses a composite material comprising the hemostatic composition and a preparation method. The hemostatic composition is small in initial swelling, and the subsequent swelling degree adjusting range is large.

Description

technical field [0001] The present invention relates to a hemostatic composition and its preparation method and application, and also relates to a composite material containing the hemostatic composition as well as its preparation method and application. Background technique [0002] In surgery, it is often necessary to hemostasis and seal wounds. When the hemostatic effect is poor and the patient loses too much blood, blood transfusion therapy is required. Traditional blood transfusion methods are limited in medical treatment due to factors such as blood shortage and short storage period of blood. In addition, blood transfusion also has the risk of transmission of blood-borne infectious diseases and adverse reactions of blood transfusion. Therefore, it is of great significance to develop biomedical materials with complete hemostasis and short hemostasis time. [0003] At present, the hemostatic materials commonly used in clinical practice are in solid form, including hem...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/10
CPCA61L24/001A61L24/0015A61L24/08A61L24/104A61L2300/252A61L2300/418A61L2400/04C08L89/00C08L5/04
Inventor 张晓金杨满王军
Owner CHENGDU MEDART MEDICAL SCI CO LTD
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