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Preparation method of molecular carrier for molecular detection

A molecular detection and molecular technology, which is applied in the field of molecular carriers, can solve the problems of sample structure damage and cumbersome detection methods, and achieve the effects of improving the enhancement factor, simple preparation method, and easy industrialization

Active Publication Date: 2022-02-08
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, the process of extracting samples may cause damage to the sample structure, and the process of extracting samples also makes the detection method cumbersome

Method used

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  • Preparation method of molecular carrier for molecular detection
  • Preparation method of molecular carrier for molecular detection
  • Preparation method of molecular carrier for molecular detection

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Embodiment Construction

[0031] The present invention will be further described in detail below in conjunction with specific embodiments and accompanying drawings.

[0032] Please also refer to Figure 1 to Figure 2 , the first embodiment of the present invention provides a molecular carrier 10 for molecular detection, the molecular carrier 10 includes a substrate 11 , an intermediate layer 12 and a metal layer 13 . Specifically, the intermediate layer 12 is disposed on the surface of the substrate 11 , and the metal layer 13 is disposed on the surface of the intermediate layer 12 . The intermediate layer 12 includes a substrate 121 and a plurality of patterned protrusions 122 disposed on the substrate 121 , and the patterned protrusions 122 are disposed on a surface of the substrate 121 away from the base 11 . The patterned protrusion 122 may include a plurality of protruding lines intersecting to form a network structure, thereby defining a plurality of holes 124 . The intersections of the plurali...

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Abstract

The invention relates to a method for preparing a molecular carrier for molecular detection, which includes the following steps: setting an intermediate layer on a substrate; providing a carbon nanotube composite structure with a plurality of micropores, the carbon nanotube composite structure comprising a carbon nanotube structure and a prefabricated layer covering the surface of the carbon nanotube structure; disposing the carbon nanotube composite structure on the surface of the intermediate layer so that the surface of the intermediate layer is partially exposed; The carbon nanotube composite structure is dry etching the middle layer with a mask to obtain a middle layer with patterned protrusions; and depositing a metal layer on the surface of the patterned protrusions.

Description

technical field [0001] The invention relates to a molecular carrier for molecular detection, a preparation method thereof and a method for detecting molecules using the carrier. Background technique [0002] Single Molecule Detection (SMD) technology is an ultra-sensitive detection technology that can detect a single molecule and is used in chemical analysis, DNA sequencing, nanomaterial analysis, medical diagnosis, molecular dynamics mechanism, food safety and other fields. Wide range of applications. Compared with traditional analysis methods, single-molecule detection method studies the individual behavior of the system in the non-equilibrium state, or the fluctuation behavior in the equilibrium state, so it is especially suitable for the study of chemical and biochemical reaction kinetics, biomolecular interactions, structure and Functional information, early diagnosis of major diseases, pathological research, and high-throughput drug screening, etc. [0003] At presen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65
CPCG01N21/65G01N21/658G01N2021/655G01N15/1484C23C14/021C23C14/14C23C14/042C23C16/0245C23C16/06C23C16/042
Inventor 王营城金元浩李群庆范守善
Owner TSINGHUA UNIV
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