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A kind of flexible membrane material and preparation method thereof for SERS detection

A flexible and membrane-like detection technology, which is applied in the fields of material analysis, material excitation analysis, and material analysis through optical means, can solve the problems of light avoidance, weak stability of metallic silver, and uneven distribution, and achieve high enhancement factor and convenient Wipe sampling, the effect of uniform thickness

Active Publication Date: 2022-04-19
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Patent No. CN110132940A specifically discloses an arrayed flexible SERS substrate and its preparation method, in which silver nanoparticles are directly added dropwise to the detection area, which is likely to cause uneven distribution. On the other hand, the stability of metallic silver is weaker than that of metallic gold, so It needs to be protected from light during the preparation process

Method used

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  • A kind of flexible membrane material and preparation method thereof for SERS detection
  • A kind of flexible membrane material and preparation method thereof for SERS detection
  • A kind of flexible membrane material and preparation method thereof for SERS detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 (see figure 1 )

[0030] 1) Preparation of PCL / CS composite solution: Dissolve 0.8g of PCL particles in 9.2g of glacial acetic acid solution at 50°C to obtain 8%wt PCL solution; dissolve 0.2g of CS powder in 9.8g of 90%wt acetic acid at 90°C solution, a 2% wt CS solution was obtained. At 50°C, 3.33g 8%wt PCL was added dropwise to 10g 2%wt CS with a mass ratio of 1:1.5, and stirred at 50°C for 2h to synthesize a PCL / CS solution.

[0031] 2) Preparation of PCL / CS flexible film: inject the PCL / CS solution into the mold, dry it at 50°C to form a film, soak it in 10% NaOH for 5 minutes, rinse and soak it with clean water until the solution is neutral. Finally, dry again in a natural state for later use.

[0032] 3) Preparation of gold seed solution: 0.025mL 0.01M HAuCl 4 solution and 0.6 mL of 0.01M NaBH 4 The solution was added to 1 mL of 0.1M CTAB solution, stirred for 30 min, and left to stand for use.

[0033] 4) Immerse the PCL / CS flexible film cut in...

Embodiment 2

[0037]1) Preparation of PCL / CS composite solution: Dissolve 0.8g of PCL particles in 9.2g of glacial acetic acid solution at 50°C to obtain 8%wt PCL solution; dissolve 0.2g of CS powder in 9.8g of 90%wt acetic acid at 90°C solution, a 2% wt CS solution was obtained. At 50°C, 3.33g 8%wt PCL was added dropwise to 10g 2%wt CS with a mass ratio of 1:1.5, and stirred at 50°C for 2h to synthesize a PCL / CS solution.

[0038] 2) Preparation of PCL / CS flexible film: inject the PCL / CS solution into the mold, dry it at 50°C to form a film, soak it in 10% NaOH for 5 minutes, rinse and soak it with clean water until the solution is neutral. Finally, it was dried again in a natural state for further use, and its morphology was characterized by SEM.

[0039] 3) Preparation of gold seed solution: 0.025mL 0.01M HAuCl 4 solution and 0.6 mL of 0.01M NaBH 4 The solution was added to 1 mL of 0.1M CTAB solution, stirred for 30 min, and left to stand for use.

[0040] 4) Immerse the PCL / CS flexi...

Embodiment 3

[0044] 1) Preparation of PCL / CS composite solution: Dissolve 0.8g of PCL particles in 9.2g of glacial acetic acid solution at 50°C to obtain 8%wt PCL solution; dissolve 0.2g of CS powder in 9.8g of 90%wt acetic acid at 90°C solution, a 2% wt CS solution was obtained. At 50°C, 3.33g 8%wt PCL was added dropwise to 10g 2%wt CS with a mass ratio of 1:1.5, and stirred at 50°C for 2h to synthesize a PCL / CS solution.

[0045] 2) Preparation of PCL / CS flexible film: inject the PCL / CS solution into the mold, dry it at 50°C to form a film, soak it in 10% NaOH for 5 minutes, rinse and soak it with clean water until the solution is neutral. Finally, dry again in a natural state for later use.

[0046] 3) Preparation of gold seed solution: 0.025mL 0.01M HAuCl 4 solution and 0.6 mL of 0.01M NaBH 4 The solution was added to 1 mL of 0.1M CTAB solution, stirred for 30 min, and left to stand for use.

[0047] 4) Immerse the PCL / CS flexible film cut into a suitable size into the gold nanopar...

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PUM

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Abstract

The invention discloses a flexible film material for SERS detection and a preparation method thereof, which is characterized in that the material is composed of gold nanoparticles and polycaprolactone (PCL) / chitosan (CS) composite polymer film, Among them, the hydrophobicity of PCL and the hydrophilicity of chitosan make the film have both hydrophilic and hydrophobic characteristics, and the gold nanoparticles play the role of surface Raman enhancement. The preparation method includes: 1. Preparation of PCL / CS composite film; 2. In-situ growth of gold nanoparticles on the composite film, which has the advantages of not only enhancing the surface Raman effect, but also enhancing the uniformity of the SERS signal and Reproducibility.

Description

technical field [0001] The invention relates to a flexible film material for SERS detection and a preparation method thereof, belonging to the technical field of surface-enhanced Raman analysis and detection. Background technique [0002] Polycaprolactone (PCL) is a linear aliphatic polyester synthetic polymer, and its molecular chain has good flexibility, so that it has excellent mechanical properties. In addition, polycaprolactone has biocompatibility, biodegradability, good flexibility and fibrilability, and is widely used in drug carriers, plasticizers, and degradable plastics, but the disadvantage of poor hydrophilicity makes it Application is restricted. [0003] Chitosan (CS) is a derivative of natural biological macromolecule chitin obtained by deacetylation, with active hydroxyl and amino groups for chemical reaction and salt formation. As a marine biomass material, chitosan is rich in sources and has many excellent properties, such as moisture absorption, reactiv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/04C08L5/08C08J7/06C08J5/18G01N21/65
CPCC08J7/06C08J5/18G01N21/658C08J2367/04C08J2405/08
Inventor 范敏卢玉栋陈彩柔姚天博游瑞云李爱民
Owner FUJIAN NORMAL UNIV
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