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Anhydrous glucose preparation process

A technology for the preparation of anhydrous glucose, which is applied in the preparation of sugar derivatives, monosaccharides, sugar derivatives, etc., can solve the problems affecting the solubility of particles, and achieve the effect of improving the purity

Inactive Publication Date: 2019-03-22
CSPC SHENGXUE GLUCOSE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The particle size and single crystal ratio will seriously affect the solubility of the particles

Method used

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  • Anhydrous glucose preparation process

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Experimental program
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Effect test

Embodiment 1

[0030] 1) Decolorization and filtration: 1.5 t of mother liquor separated from the production of glucose monohydrate, with a glucose purity of 80%, is decolorized by activated carbon at 80° C. and pH 4.3, and the decolorization time is set at 25 minutes. Take the method of decolorization in stages, and decolorize with used activated carbon for 10 minutes before decolorization, and decolorize with new activated carbon for 25 minutes after decolorization. First pass through weakly acidic cation exchange resin, and then pass through three groups of weakly basic anion exchange resins (in turn through three groups of yang and yin, yang and yin, and yang and yin) to remove inorganic salts and organic impurities, and filter to obtain glucose with a purity of 82.5%. Liquid 1.3t.

[0031] 2) Crystallization: The filtered glucose liquid enters the crystallization tank, adopts a vacuum boiling sugar tank (without special modification), and stably controls the vacuum degree at 0.85×10 5 ...

Embodiment 2

[0037] 1) Decolorization and filtration: 1.5 t of mother liquor separated from the production of glucose monohydrate, with a glucose purity of 80.7%, is decolorized by activated carbon at 80° C. and pH 4.3, and the decolorization time is set at 25 minutes. Take the method of decolorization in stages, and decolorize with used activated carbon for 10 minutes before decolorization, and decolorize with new activated carbon for 25 minutes after decolorization. First pass through weakly acidic cation exchange resins, and then pass through three groups of weakly basic anion exchange resins (three groups, which are followed by positive and negative, positive and negative, positive and negative three groups), to remove inorganic salts and organic impurities, and filter to obtain a purity of 81.8% glucose solution 1.31t.

[0038] 2) Crystallization: The filtered glucose liquid enters the crystallization tank, adopts a vacuum boiling sugar tank (without special modification), and stably ...

Embodiment 3

[0044] 1) Decolorization and filtration: 1.5 t of mother liquor separated from the production of glucose monohydrate, with a glucose purity of 80%, is decolorized by activated carbon at 80° C. and pH 4.3, and the decolorization time is set at 25 minutes. Take the method of decolorization in stages, and decolorize with used activated carbon for 10 minutes before decolorization, and decolorize with new activated carbon for 25 minutes after decolorization. First pass through weakly acidic cation exchange resins, and then pass through three groups of weakly basic anion exchange resins (three groups, which are followed by positive and negative, positive and negative, positive and negative three groups), to remove inorganic salts and organic impurities, and filter to obtain a purity of 82.4% glucose solution 1.3t.

[0045]2) Crystallization: The filtered glucose liquid enters the crystallization tank, adopts a vacuum boiling sugar tank (without special modification), and stably cont...

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Abstract

The invention discloses a production process for improving the crystal form and particle size indexes of anhydrous glucose. Through the production process, the percentage of the anhydrous glucose product on an 80-mesh sieve reaches the crystal form index of 85 percent or more than 85 percent, and the single crystal rate of the crystal form index reaches 85 percent or more than 85 percent. According to the anhydrous glucose product prepared by the process, the dissolubility of the anhydrous glucose product can be greatly improved; the requirement of quickly dissolving in injection water in a short time is met; the anhydrous glucose product can be quickly used for a patient with acute and chronic renal failure after being filtered. When the anhydrous glucose is used in infusion industry, theproduction efficiency can also be greatly improved. The anhydrous glucose preparation process comprises the following steps: (1) decolouring and filtering; (2) crystallizing; (3) separating; (4) drying; and (5) screening.

Description

technical field [0001] The invention belongs to the technical field of pharmacy and relates to a preparation process of anhydrous glucose. Background technique [0002] In the current anhydrous glucose industry, the particle size of most enterprises' products is about 35-40% on the 80 mesh sieve, and the average single crystal rate is at the level of 45%. When anhydrous dextrose is used as the main component in the preparation of peritoneal dialysis fluid, it needs to be dissolved quickly before it can be used for patient treatment. The particle size and single crystal ratio will seriously affect the solubility of particles. Therefore, high requirements are put forward for particle size index and crystal form index. Contents of the invention [0003] The purpose of the present invention is to address the above-mentioned technical deficiencies, to provide a production process for improving the particle size index of anhydrous glucose crystal form, so that the particle siz...

Claims

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Application Information

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IPC IPC(8): C07H3/02C07H1/06
CPCC07H1/06C07H3/02
Inventor 鄢飞华梁红霞李忠玉姚彩霞罗倩赵金红刘刚
Owner CSPC SHENGXUE GLUCOSE CO LTD
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