Traditional Chinese medicine composition for organ fibrosis and preparation method and application thereof

A composition and fibrosis technology, which can be used in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of unclear efficacy of traditional Chinese medicine in treating tissue fibrosis, and achieve diverse drug delivery methods and wide application prospects. Effect

Active Publication Date: 2019-03-26
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, the curative effect of traditional Chinese medicine for treating tissue fibrosis is still unclear. The purpose of the present invention is to make up for the deficiencies in the prior art and provide a Chinese medicine composition prepared for visceral fibrosis

Method used

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  • Traditional Chinese medicine composition for organ fibrosis and preparation method and application thereof
  • Traditional Chinese medicine composition for organ fibrosis and preparation method and application thereof
  • Traditional Chinese medicine composition for organ fibrosis and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 Chinese medicine composition capsule

[0025] Chinese medicine composition of the present invention is prepared according to the following method:

[0026] Raw materials: 124g dragon's blood, 124g Panax notoginseng, 200g fritillary fritillaria, 352g coix seed;

[0027] Preparation method: the above four flavors, Panax notoginseng and dragon's blood are directly crushed into fine powder and used as medicine; the medicinal materials of Fritillaria fritillaria are crushed into coarse powder, soaked in 85% ethanol for 36 hours, then percolated with 85% ethanol, and 16 times the amount of percolation fluid is collected , to obtain the extract of Fritillaria japonicus; Coix seed is crushed into coarse powder, and refluxed with 30 times the amount of 95% ethanol to extract 3 times, each time for 3 hours, the extracts are combined and filtered to obtain the extract of Coix seed; the above-mentioned extract of Fritillaria coix Extraction of Coix ...

Embodiment 2

[0028] The preparation of embodiment 2 Chinese medicine composition tablet

[0029] Raw materials: 124g dragon's blood, 124g Panax notoginseng, 200g fritillary fritillaria, 352g coix seed;

[0030] Preparation method: the above four flavors, Panax notoginseng and dragon's blood are directly crushed into fine powder and used as medicine; the medicinal materials of Fritillaria fritillaria are crushed into coarse powder, soaked in 75% ethanol for 24 hours, then percolated with 75% ethanol, and 12 times the amount of percolation fluid is collected , to obtain the extract of Fritillaria japonicus; Coix seed is crushed into coarse powder, extracted twice with 20 times the amount of 90% ethanol under reflux, each time for 2 hours, the extracts are combined, and filtered to obtain the extract of Coix seed; the above-mentioned extract of Fritillaria coix Coix seed extract and coix seed extract were respectively recovered ethanol under reduced pressure, and concentrated to a thick paste...

Embodiment 3

[0031] The preparation of embodiment 3 Chinese medicine composition granules

[0032] Raw materials: 170g dragon's blood, 170g Panax notoginseng, 160g fritillary fritillaria, 280g coix seed;

[0033] Preparation method: the above four flavors, Panax notoginseng and dragon's blood are directly crushed into fine powder and used as medicine; the medicinal materials of Fritillaria fritillaria are crushed into coarse powder, soaked in 75% ethanol for 24 hours, then percolated with 75% ethanol, and 12 times the amount of percolation fluid is collected , to obtain the coix seed extract; coix seed is crushed into coarse powder, and extracted twice with 16 times the amount of 90% ethanol under reflux, each time for 2 hours, the combined extracts are filtered to obtain the coix seed extract; the above-mentioned Zhe Fritillaria extract Coix seed extract and coix seed extract were respectively recovered ethanol under reduced pressure, and concentrated to a thick paste. The obtained thick ...

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Abstract

The invention provides a traditional Chinese medicine composition for organ fibrosis. The traditional Chinese medicine composition is characterized by being prepared from the following components according to a weight ratio: 40 to 85 parts of dragon's blood, 40 to 85 parts of radix notoginseng, 80 to 125 parts of bulbus fritillariae thunbergii, and 140 to 210 parts of semen coicis. Proofed by experiment, the traditional Chinese medicine composition has the advantages that the fibrosis of liver, lung, uterus and kidney organs can be effectively treated by low, medium and high doses, and the dose reliance is realized; and the administration type is diversified, the defects of the existing medicine are overcome, and the application prospect is broad.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine application, and in particular relates to an application in preparing medicine for treating visceral fibrosis. Background technique [0002] Fibrosis is a concept in medicine. Fibrosis can occur in various organs in the body. The main pathological changes are the increase of fibrous connective tissue in organ tissues and the reduction of parenchymal cells. Continuous progress can lead to organ structural damage and functional decline. Even failure, a serious threat to human health and life. [0003] Body organs are composed of parenchyma and interstitium. The parenchyma refers to the main structure and functional cells in the tissue. The interstitium is composed of interstitial cells and extracellular matrix, which plays a role in mechanical support and connection in the tissue. As long as any reason can cause tissue damage, it can lead to degeneration, necrosis and inflammatory respon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P43/00A61P1/16A61P11/00A61P13/12A61P15/00
CPCA61K36/896A61K36/8966A61K36/8994A61P1/16A61P11/00A61P13/12A61P15/00A61P43/00A61K36/258A61K2236/333A61K2236/53A61K2300/00
Inventor 肖伟吕耀中连洁周军吴云王振中
Owner JIANGSU KANION PHARMA CO LTD
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