A traditional Chinese medicine composition preparation for preventing and treating postmenopausal osteoporosis and its preparation and application

A technology for osteoporosis and composition, which is applied in the field of traditional Chinese medicine composition preparation to achieve the effect of improving curative effect and remarkable drug effect

Active Publication Date: 2022-03-15
SHAANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention has not yet seen reports on the composition of Flying Centipede Seven, Pearl Ginseng, Gynostemma pentaphyllum and Gardenia

Method used

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  • A traditional Chinese medicine composition preparation for preventing and treating postmenopausal osteoporosis and its preparation and application
  • A traditional Chinese medicine composition preparation for preventing and treating postmenopausal osteoporosis and its preparation and application
  • A traditional Chinese medicine composition preparation for preventing and treating postmenopausal osteoporosis and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Prescription: 15 parts of Flying Centipede Seven, 20 parts of Jiaogulan, 20 parts of Pearl Ginseng and 15 parts of Gardenia.

[0030] Preparation method: take 15g of flying centipede seven medicinal materials, 20g of Gynostemma pentaphyllum medicinal material, 20g of pearl ginseng medicinal material, and 15g of gardenia medicinal material, grind them through a 20-mesh sieve, add 700mL of 50% ethanol aqueous solution with volume concentration, soak at room temperature (20-30°C) for 4h, Then use 20 kHz ultrasonic extraction for 1 hour, then heat and reflux for extraction for 1 hour, filter to obtain a filtrate and a filter residue, add 700 mL of 50% ethanol aqueous solution to the filter residue, then use 20 kHz ultrasonic extraction for 1 hour, and then heat and reflux Extract for 1 hour, filter to obtain the secondary filtrate and secondary filter residue, combine the primary filtrate and the secondary filtrate, concentrate to a relative density of 10mg / mL, absorb with A...

Embodiment 2

[0032] Prescription: 20 parts of Flying Centipede Seven, 15 parts of Jiaogulan, 15 parts of Pearl Ginseng and 20 parts of Gardenia.

[0033] Preparation method: Take 20g of the medicinal materials of flying centipede seven, 15g of Gynostemma pentaphyllum, 15g of ginseng and 20g of gardenia medicinal materials, grind them through a 30-mesh sieve, add 1050mL of 40% ethanol aqueous solution with a volume concentration, soak at room temperature (20-30°C) for 6h, Then use 30 kHz ultrasonic extraction for 0.5 hours, then heat and reflux to extract for 2 hours, filter to obtain a filtrate and a filter residue, add 1050 mL of 40% ethanol aqueous solution to the filter residue, then use 30 kHz ultrasonic extraction for 0.5 hours, and then heat to reflux Extract for 2 hours, filter to obtain the secondary filtrate and secondary filter residue, combine the primary filtrate and the secondary filtrate, concentrate to a relative density of 15 mg / mL, absorb with AB-8 macroporous resin, and th...

Embodiment 3

[0035] Prescription: 20 parts of Flying Centipede Seven, 20 parts of Jiaogulan, 20 parts of Pearl Ginseng and 20 parts of Gardenia.

[0036] Preparation method: Take 20g of the medicinal materials of the flying centipede seven, 20g of the Gynostemma pentaphyllum, 20g of the ginseng medicinal material, and 20g of the gardenia medicinal material, grind them through a 40-mesh sieve, add 1200mL of 60% ethanol aqueous solution with a volume concentration, soak at room temperature (20-30°C) for 8h, Then use 40 kHz ultrasonic extraction for 1 hour, then heat and reflux for 1 hour, filter to obtain a filtrate and a filter residue, add 1200 mL of 60% ethanol aqueous solution to the filter residue, then use 40 kHz ultrasonic extraction for 1 hour, and then heat to reflux Extract for 1 hour, filter to obtain the secondary filtrate and secondary filter residue, combine the primary filtrate and the secondary filtrate, concentrate to a relative density of 20 mg / mL, absorb with AB-8 macroporo...

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Abstract

The invention discloses a traditional Chinese medicine composition preparation for treating postmenopausal osteoporosis and its preparation and application. The traditional Chinese medicine composition is prepared from raw materials with the following mass proportions: 5-200 parts of centipede seven, 10 parts of Jiaogulan ~300 parts, 10~300 parts of ginseng, 5~200 parts of gardenia. The preparation compatible with the traditional Chinese medicine composition has remarkable effect in treating postmenopausal osteoporosis.

Description

(1) Technical field [0001] The invention relates to a traditional Chinese medicine composition preparation, which is specifically made from four traditional Chinese medicines of flying centipede seven, gynostemma pentaphyllum, pearl ginseng and gardenia. The traditional Chinese medicine composition preparation can effectively treat postmenopausal osteoporosis and belongs to field of medical technology. (2) Background technology [0002] Postmenopausal osteoporosis refers to postmenopausal women due to ovarian function decline, estrogen levels drop, and follicle-stimulating hormone levels increase, so that in the process of bone metabolism, bone resorption is greater than bone formation, resulting in osteopenia and bone microscopic It is a systemic metabolic disease characterized by structural degeneration, resulting in increased bone fragility and susceptibility to fracture. Due to the emergence of menopause, women's bone density decreases rapidly, and the incidence of frac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/888A61P15/00A61P19/10
CPCA61K36/888A61P15/00A61P19/10A61K36/25A61K36/344A61K36/424A61K36/744A61K2236/333A61K2236/55A61K2236/39A61K2300/00
Inventor 潘亚磊李引刚唐志书谢培雷莉妍周瑞宋忠兴
Owner SHAANXI UNIV OF CHINESE MEDICINE
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