Method for preparing 2,2,3,3,3-pentafluoro-1-propanol

Abstract

The invention discloses a method for preparing 2,2,3,3,3-pentafluoro-1-propanol. According to the method, pentafluoropropionate with a general formula of CF3CF2COOCnH(2n+1) is taken as a raw materialfor preparing 2,2,3,3,3-pentafluoro-1-propanol through a one-step process under the existence of a catalyst. M-KF / Al2O3 is served as the catalyst; catalytic active metal M is one or more of Pt, Au, Pd, Ag and Cu; mass percent of the catalytic active metal M in the catalyst is 0.1%-20%; the pentafluoropropionate with the general formula of CF3CF2COOCnH(2n+1) is composed of methyl pentafluoropropionate and ethyl pentafluoropropionate; in the invention, reaction temperature is at 40 DEG C-100 DEG C, reaction time is 1h-8h, and mass ratio of pentafluoropropionate to catalyst is at 1:(0.05-0.2); the method for preparing 2,2,3,3,3-pentafluoro-1-propanol provided by the invention has the advantages of few reaction step, simple operation, low-cost and easily acquired raw materials, high yield andmild reaction condition.

Description

Technical field [0001] The invention belongs to the field of fluorine chemicals and relates to a preparation method of 2,2,3,3,3-pentafluoropropanol. Background technique [0002] ODS cleaning agent (ODS is the abbreviation of "Ozone Depleting Substance", meaning "ozone depleting substance") is an important class of substances commonly used in human life and industry. It has the characteristics of low toxicity, non-combustibility, and chemical inertness, so it is widely used It is used as a refrigerant, foaming agent, aerosol, and cleaning agent for electronic components and precision parts. Its application range covers households and all walks of life, and it has become an indispensable product for modern life. [0003] However, ODS cleaning agent has a strong destructive effect on the ozone layer and will cause global temperature warming. According to the effective "Montreal Protocol on Substances that Deplete the Ozone Layer" and the "Overall ODS Phase-out Plan for China's Clea...

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Problems solved by technology

[0006] The existing methods for synthesizing 2,2,3,3,3-pentafluoropropanol are mainly addition method and catalytic hydrogenation method, both of which have many synthesis steps, complicated operation, expensive reagents, and low yield.

[0007] Japanese patent JP 06072925 reported that in liquid HF, TiF4 was used as a catalyst to obtain 2,2,3,3,3-pentafluoropropanol through the addition reaction of trioxane and tetrafluoropropene. The method used liquid HF, TiF 4 and other reagents, which are highly polluting, highly toxic, unfriendly to the environment, and have high safety risks; US4273947 reported that 2,2,3,3,3-pentafluoropropionic acid was used as a raw material in the presence of a Ru / C catalyst to undergo catalytic hydrogenation in one step Synthesis of 2,2,3,3,3-pentafluoropropanol, the raw material price of this method is high, it is difficult to industrialize, and it needs to react under the condition of hydrogen, which has a large safety risk; PTC2002026679 reported 2,2,3,3 , 3-pentafluoropropanamide is used as a raw material to synthesize 2,2,3,3,3-pentafluoropropanol in one step through catalytic hydrogenation in the presence of a Pd / C catalyst. This method has high raw material prices, is difficult to industrialize, and requires Reaction under hydrogen conditions, there is a greater safety risk

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