Cleaning machine cleaning testing method based on laser distance measuring

Abstract

The invention discloses a cleaning machine cleaning testing method based on laser distance measuring. The method comprises the following steps of 1, acquiring an initial distance L; 2, based on the initial distance L, making a laser sensor move for one circle along a barrel wall, obtaining distance data, using the distance data as the number between the laser sensor and the barrel wall, and makingrelative initial positions of n points on the barrel wall fluctuate; 3, establishing a rectangular coordinate system; 4, calculating a surface roughness value; 5, dividing n points into k intervals,k>=1, wherein m points exist in one interval, obtaining k surface roughness values Rak according to the surface roughness value in the step 4; 6, calculating an average value [mu]k and a standard deviation sigmak of the Rak, and establishing an interval [([mu]k+3sigmak),([mu]k-3sigmak)]; and 7, comparing a mean value [mu]k with the Ra in the step 4, and if [mu]k>=5Ra, proving existence of an adhesive substance. According to the method, a laser distance measuring method is combined with the surface roughness. The method is used for discriminating the surface roughness change of a hopper, thereby representing whether particles residue at the surface of the hopper.

Description

technical field [0001] The invention relates to the technical field of medicine machine cleaning, in particular to a cleaning and detection method for cleaning machines based on laser ranging. Background technique [0002] In the production of solid preparations, mixing, feeding and transfer, and cleaning of equipment are often inseparable. However, the most prominent problem in the production of most solid preparations in my country is the cleaning of tools (that is, the cleaning of hoppers). The purpose of equipment cleaning validation is defined from the "Guidelines for Pharmaceutical Production Validation (2003)", "The purpose of equipment cleaning validation is to prove through testing that the automatic cleaning procedure or manual cleaning procedure of the equipment can remove active drug residues on equipment parts , and meet the acceptable standards, and prove the stability and repeatability of this cleaning procedure.” Although the existing single-chamber and doubl...

AI Technical Summary

Problems solved by technology

"Although the existing single-chamber and double-chamber hopper cleaning machines get rid of the manual cleaning method and adopt the automatic intelligent cleaning method, the cleaning method adopts a single solution, that is, the cleaning machine completes cleaning according to the program requirements, and the key parameters such as cleaning method and time are in accordance with It is set by experience to complete the cleaning process of the hopper. At this time, the cleaning system does not know whether there are residual drug dust particles on the barrel wall.

[0003] At present, the water quality after cleaning is tested to indirectly explain the cleanliness of the cleaning. Facts have proved that this method cannot explain whether there is residue on the barrel wall

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