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One step cardiac test device

A test strip and human detection technology, applied in the field of immunoassay, can solve problems such as insufficient diagnostic accuracy

Inactive Publication Date: 2019-04-02
NOVAMED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Heart-type fatty acid binding protein (HFBP) has been found to be another AMI marker, and conveniently, this protein appears in the blood within about 1 hour of an AMI event and peaks within about 5 hours [Tanaka T. et al. : Clinical Biochemistry 24(1991) 195–201; Van NieuwenhovenF.A. et al: Circulation 92(1995) 2848–54], but the diagnostic accuracy of HFBP as a marker alone was found to be insufficient in a clinical setting [Park S.Y. et al.: Clin. Neurol. Neurosurg. 115(2013) 405-10]

Method used

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  • One step cardiac test device

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Experimental program
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Embodiment

[0015] Antibody conjugates were obtained that provided chromogenic reactions with CT, HFBP or human serum albumin, in particular anti-Troponin I, anti-HFBP and anti-HSS. Antibody conjugates were immobilized in narrow bands on capillary bed paper to construct immobilized antibody conjugates. A lateral flow immunoassay device (LFID) was prepared using dipstick. By fixing the amount / concentration of a series of conjugates (for conjugate immobilization, a volume of a certain concentration is applied to the test paper, which volume corresponds to the total amount of different chromogenic reagents in the strip), and by applying The strips were reacted with a series of samples containing different antigen concentrations and the amount of reagent needed to achieve the desired signal intensity was determined for all antigens. Determine the following threshold amounts / concentrations: the amount of anti-TnTnI for the detection of 1 ng / ml Troponin I in the sample, the amount of Anti-FABP...

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Abstract

The invention provides a device for detecting diagnostic blood markers as early as half an hour upon an acute myocardial infarction symptoms onset.

Description

field of invention [0001] The present invention relates to immunoassays for the detection of cardiac markers in the early stages of a cardiac event, such as myocardial infarction. In particular, the present invention provides a device for detecting a diagnostically relevant combination of two blood markers as early as half an hour after the onset of symptoms of acute myocardial infarction. Background technique [0002] In the United States alone, approximately one million people suffer from acute myocardial infarction (AMI) each year, 10% of whom may die within a year, depending on the severity of the event and the quality of the intervention. In all cases, medical assistance should be provided as soon as possible, including first percutaneous coronary intervention and / or thrombolytic therapy if needed. Reducing the duration between the onset of chest pain and reperfusion to less than about 4 hours has been found to be critical to reducing myocardial necrosis and improving ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B10/00G01N33/53G01N33/68
CPCG01N2333/4712G01N2800/324G01N33/6893G01N33/53G01N33/68G01N33/92G01N33/54388
Inventor E·卡茨T·特贝里
Owner NOVAMED
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