Herba viticis formula granules and preparation method thereof
A technology of formula granules and five-finger mandarin oranges is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., to achieve the effects of improving stability, easy storage, and uniform particle size.
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[0026] The preparation method of Wuzhigan formula granules of the present invention comprises the following steps:
[0027] (a) get the five-finger mandarin orange medicinal material, add the ethanol aqueous solution of 15-18 times volume of feeding amount and mix;
[0028] (b) Ultrasonic extraction 2-3 times, filtering;
[0029] (c) concentrating the gained filtrate under reduced pressure to a concentrated solution with a relative density of 1.1-1.2;
[0030] (d) mixing the concentrated solution with auxiliary materials;
[0031] (e) freeze-drying;
[0032] (f) pulverize the dry matter obtained in step (e), and then pass through an 80-mesh sieve;
[0033] (g) placing the sieve obtained in step (f) in a mixing tank and mixing to obtain Wuzhigan cream powder;
[0034] (h) making the quinquefolium extract powder into granules, and then sizing the obtained granules with a 20-mesh sieve and a 50-mesh sieve in turn.
[0035] In the method of the present invention, in terms of ...
Embodiment 1
[0048] (1) Get 1kg of mandarin orange medicinal material, add the aqueous ethanol solution (concentration is 40% by weight) of 16.5 times of feed intake, ultrasonically extract 3 times under the ultrasonic frequency of 90kHz, extract 45 minutes each time, filter with 200 mesh stainless steel screens, The filtrate was concentrated under reduced pressure to a concentrated solution with a relative density of 1.15;
[0049] (2) Add 100g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.25:1) to the concentrated solution for mixing, freeze-dry, collect the dry cream powder, crush it through an 80-mesh sieve, and mix it in a mixing tank ;
[0050] (3) Take Wuzhigan paste powder, sieve and granulate, and granulate the granules with a 20-mesh sieve and a 50-mesh sieve in turn to obtain the Wuzhigan formula granule sample A1.
Embodiment 2
[0052] (1) Get 1kg of mandarin orange medicinal material, add the aqueous ethanol solution (concentration is 45% by weight) of 15 times of feeding amount, ultrasonic extraction 2 times under the ultrasonic frequency of 125kHz, extract 60 minutes each time, filter with 200 mesh stainless steel screens, The filtrate is concentrated under reduced pressure to a concentrated solution with a relative density of 1.1;
[0053] (2) Add 80g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.25:1) to the concentrated solution for mixing, freeze-dry, collect the dry cream powder, crush it through an 80-mesh sieve, and mix it in a mixing tank ;
[0054] (3) Take Wuzhigan paste powder, sieve and granulate, and granulate the granules with a 20-mesh sieve and a 50-mesh sieve in turn to obtain the Wuzhigan formula granule sample A2.
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