Method for screening regulation new gene participating in biological process

Abstract

The invention discloses a method for screening a regulation new gene participating in the biological process. A biologic informatics method is used for searching gene ontology for a tool, and the semantic relation in the specific biological process is screened out; in a genome annotation database of different species, gene set information in different species annotated to the semantic is screenedout; homology analysis is performed on the gene set information of the specific species, an orthologous gene in the species to be researched is screened out; comparison and analysis are performed on the gene and the reference gene participating in the biologic process in the species to be researched, and the regulation new gene participating in the biologic process in the specific species is screened out. On the basis that the specific biologic process has the advantage of high conservative property between different species, a method for screening the regulating new gene participating in thebiologic process is built, the supporting effect is supplied for further reconstructing a systematic gene regulation network, and the method is of a great significance in early disease diagnosis, individual treatment and medicine development.

Description

technical field [0001] The invention belongs to the technical field of biological information, and relates to a method for screening new genes involved in biological process regulation. Background technique [0002] Gene regulatory network (Gene Regulatory Networks, GRN) is a complex regulatory network that represents the interaction between genes. Through the gene regulatory network, the interaction relationship between genes can be systematically analyzed and understood, and the operating mechanism of cell life activities can be understood and mastered, so as to find the key genes that cause diseases. This plays a vital role in the treatment of complex diseases (such as radiation-induced cancer, etc.), and research in this field has become one of the research hotspots in bioinformatics and systems biology. In recent years, gene regulatory networks have been increasingly applied to research fields such as disease gene prediction and drug target screening, and have played a...

AI Technical Summary

Problems solved by technology

However, this method has many disadvantages, such as long time-consuming, expensive, etc. In most cases, it is difficult to identify new genes involved in a specific gene regulatory network, which limits the reconstruction and application of gene regulatory networks

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