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A Phase Difference Analysis Doppler Imaging Method

An imaging method and phase difference technology, which can be used in the analysis of materials, the measurement of phase influence characteristics, and the analysis of materials by optical means. Measurement and other issues, to achieve high-speed detection sensitivity, dynamic imaging, and high precision

Active Publication Date: 2021-06-01
HUAQIAO UNIVERSITY
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Problems solved by technology

[0009] It can be seen that the OCT technology combined with Doppler forms a new type of biomedical imaging technology, but the current OCT technology is difficult to achieve dynamic image measurement of high-speed vibrating samples such as cardiovascular systems, the system's signal-to-noise ratio and system Modulation frequency is limited, making it difficult to obtain high speed detection sensitivity
In addition, when imaging living organisms, the large-amplitude and high-speed motion in the sample to be tested will cause the time spectrum after Fourier transform to alias (that is, mix), which will make it difficult to obtain the Doppler frequency spectrum of the sample to be tested. le image

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  • A Phase Difference Analysis Doppler Imaging Method
  • A Phase Difference Analysis Doppler Imaging Method
  • A Phase Difference Analysis Doppler Imaging Method

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Embodiment Construction

[0038] An imaging method for obtaining a Doppler image by performing phase difference in the spatial domain by using a sinusoidal phase modulation complex frequency domain optical coherence tomography system. The specific steps of the method are as follows:

[0039] 1) Use the sinusoidal phase modulation complex frequency domain optical coherence tomography system to image biological samples that move at high speed and vibrate greatly: while the two-dimensional galvanometer system scans the sample horizontally (B-SCAN), the piezoelectric ceramic Drive the vibration of the reference mirror (M-SCAN) so that it makes a sinusoidal vibration acos(2πf c t+θ), thus introducing a sinusoidal phase 2kacos(2πf c t+θ), that is, sinusoidal phase modulation; the vibration of the sample can be expressed as: z 10 (t)=z 0 +bcos(2πf 0 t+θ 0 );

[0040] Among them, f c is the frequency of sinusoidal vibration of the reference mirror; b is the vibration amplitude of the sample to be tested;...

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Abstract

The invention discloses a phase difference analysis Doppler imaging method, comprising the following steps: 1) using a sinusoidal phase modulation complex frequency domain optical coherence tomography system to image a sample to be tested that moves at high speed and vibrates greatly; 2) Perform Fourier transform on the collected two-dimensional interference spectrum signal along the wavenumber domain; 3) extract the phase information of the complex tomography signal, and perform differential processing on the phases of adjacent acquisition time intervals of the signal one by one to obtain the two-dimensional tomography phase difference; 4) using the two-dimensional tomography phase difference that changes with time and the amplitude reconstruction of the complex tomography signal that changes with time to form a two-dimensional difference tomography signal that contains phase difference; 5) for the The two-dimensional differential tomographic signal is Fourier transformed along the time domain, and the differential frequency domain tomographic signal is obtained through sinusoidal phase demodulation, in which the phase information is the Doppler image of the measured biological sample over time.

Description

technical field [0001] The invention relates to the technical field of Fourier domain optical coherence tomography, in particular to a sinusoidal phase modulation complex frequency domain Doppler optical coherence tomography method. Background technique [0002] Optical coherence tomography OCT (optical coherence tomography, OCT) is an imaging technology with high-resolution, non-destructive, real-time imaging capabilities, and the characteristics of easy docking with existing instruments, so it has a broad application prospect. [0003] The development of OCT has successively formed two categories called time domain OCT and Fourier domain OCT. Time-domain OCT uses a reference mirror to scan axially to match the back-reflected scattered light at different depths of the sample. Time-domain OCT needs to scan axially point by point, and the imaging speed is limited. Fourier domain OCT does not need a moving mechanism for axial scanning. The beams returned by the sample and the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/45G01N21/84
CPCG01N21/45G01N21/84
Inventor 蒲继雄陈红芩佐佐木修己陈子阳
Owner HUAQIAO UNIVERSITY
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