Application of piperlongumine in the preparation of anti-bacterial and anti-inflammatory drugs

A longanamide, antibacterial and anti-inflammatory technology, which is applied in the field of biomedicine and can solve problems such as no reports on the application of longanamide antibacterial and anti-inflammatory drugs.

Inactive Publication Date: 2019-04-12
GENERAL HOSPITAL OF PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, according to the prior art, perylene amide is mainly used in the preparation of drugs such as anti-tumor, treatment or prevention of thromboembolic diseases, and there is no report on the application of perylene amide in the preparation of antibacterial and anti-inflammatory drugs.

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  • Application of piperlongumine in the preparation of anti-bacterial and anti-inflammatory drugs
  • Application of piperlongumine in the preparation of anti-bacterial and anti-inflammatory drugs
  • Application of piperlongumine in the preparation of anti-bacterial and anti-inflammatory drugs

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Embodiment Construction

[0023] The following examples are provided to further illustrate but not limit the present invention.

[0024] 1. Materials and methods:

[0025] 1.1 Bacteria and cells

[0026] Fusobacterium nucleatum (F. nucleatum, Fn, ATCC 25586) was obtained from the frozen bacterial strain bank of the Key Laboratory of Oral Tissue Regeneration in Shandong Province.

[0027] Gingival fibroblasts (HGF): isolated from 6 volunteer patients aged 18-30 who underwent extraction of impacted teeth.

[0028] 1.2 Reagents

[0029] Defibrinated sheep blood (Haibo Bio Company, Qingdao, Shandong, China), PBS (Soleibao, Beijing, China), hemin-vitamin K1 (Haibo Bio Company, Qingdao, Shandong, China), brain Heart infusion blood culture medium (Suolaibao, Beijing, China), BHI liquid medium (Suolaibao, Beijing, China), type I collagenase (Suolaibao, Beijing, China), DispaseII dispase (Invitrogen, Carlsbad, CA, USA), Intracellular ROS Detection Kit (Bebo, Shanghai), Piperonamide (MedChemExpress, Shanghai...

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Abstract

The invention discloses an application of piperlongumine in the preparation of anti-bacterial and anti-inflammatory drugs. By performing RNA-seq transcriptome analysis for the cells of people infectedwith bacteria, a list of drug candidates with functions of antisepsis and anti-inflammation can be obtained on account of analysis methods of co-expression pathway and drug gene aggregation, whereinthe list comprises a plurality of marketed drugs with anti-bacterial and anti-inflammatory effects, the piperlongumine not discovered to have anti-bacterial and anti-inflammatory effects is right in the list. Therefore, the piperlongumine can be used in the preparation of anti-bacterial and anti-inflammatory drugs.

Description

technical field [0001] The invention relates to new uses of medicines, in particular to new uses of perylene amide, specifically the application of perylene amide in the preparation of antibacterial and anti-inflammatory drugs, and belongs to the field of biomedicine. Background technique [0002] Piperlongumine (Piperlongumine) is a natural alkaloid compound present in Piper longumine, which has anti-malignant tumor, anti-platelet aggregation, regulation of blood lipid metabolism, anti-Parkinson's disease, promotion of melanocyte proliferation, anti-inflammation, It has antifungal effects, but has no obvious toxic and side effects on normal cells, tissues, and organs (see Li Lianjian, Chen Chunlei. The pharmacological mechanism and research progress of pinionamide[J]. Hainan Medicine, 2015(14): 2113- 2115.). [0003] Perylene amide can increase the level of reactive oxygen species (ROS) in cells and selectively kill cancer cells. It inhibits gastric cancer by inhibiting T...

Claims

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Application Information

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IPC IPC(8): A61K31/4412A61K45/06A61P31/04
CPCA61K31/4412A61K45/06A61P31/04
Inventor 贾志龙何昆仑冯强康文燕王卫东石金龙赵晓静贾倩刘春蕾
Owner GENERAL HOSPITAL OF PLA
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