Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of microneedles

A technology of microneedles and needle tips, which is applied in the field of preparing microneedle arrays, can solve the problems of low efficiency, high cost, complicated preparation process, etc., and achieve the effect of simple and efficient method, controllable shape and size, and good mechanical properties

Pending Publication Date: 2019-05-14
成都华航创微科技有限公司
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned prior art, its preparation process all is very complicated, and efficiency is low and cost is higher

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of microneedles
  • Preparation method of microneedles
  • Preparation method of microneedles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1, select lipophilic material, such as 3D printing photosensitive resin material as the printing material of the printing material layer 2 and drop it on the surface of the printing platform 4 with a silica gel film as the non-stick cushion layer 7, and avoid the formation of air bubbles during the liquid addition process After the exposure and molding of the microneedles are affected, the slide glass 5 is installed on the adjustment platform 9, and the distance between the slide glass 5 and the printing platform 4 is adjusted to be 1mm by controlling the adjustment platform 9; observe the distance between the slide glass 5 and the printing platform 4 Whether it is kept in a horizontal state and the slide glass 5 is fully in contact with the photosensitive material to ensure that the height of the needle tip structure 3 formed by exposure is consistent. Then start the 3D printer to project the pre-set printing beam 1, and control the exposure of the printing b...

Embodiment 2

[0039] Embodiment 2, select hydrophilic material, such as 30% PEGDA, 2.1% Lap material as the printing material of printing material layer 2 and drip onto the surface of printing platform 4 with silica gel film as non-stick cushion layer 7, in the process of adding liquid The generation of air bubbles should be avoided to affect the exposure molding of microneedles. Then slide glass 5 is installed on the adjusting table 9 again, and the distance between the slide glass 5 and the printing platform 4 is 1mm by controlling the adjusting table 9; The slide glass 5 is fully contacted with the photosensitive material to ensure that the needle point structure 3 formed by exposure is highly consistent. Then start the 3D printer, project the pre-set printing beam 1, and control the exposure of the printing beam 1 for 15 seconds before ending.

[0040] According to the microneedle preparation method of the present invention, according to the photosensitive material selected, the thickn...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of microneedles and belongs to the technical field of 3D printing technologies and medical equipment. With the adoption of the preparation method of the microneedles, the preparation method is simple and efficient, the shape and size are controllable, and the preparation method has the good mechanical property. According to the preparation method of themicroneedles, a 3D printer based on a DLP principle is utilized, so that conical-tip-shaped needlepoint structures are exposed and formed in a printing material layer by controlling exposure time T of printing light beams. The 3D printer based on the DLP principle is directly used for preparation, for instance, light-sensitive materials are subjected to exposure forming through ultraviolet illumination, and the effect that the light intensity, which is in the printing material layer and located at the same cross section, of the printing light beams is gradually weakened from the centers of the light beams to the peripheries, and the light intensity at the same longitudinal section is gradually weakened from the end close to a light source to the end far away from the light source is utilized, so that the needlepoint structures of the microneedles are formed at one time by controlling the specific exposure time T.

Description

technical field [0001] The invention relates to a principle and method for preparing a microneedle array. Background technique [0002] Microneedles, that is, tiny needles, use microneedle arrays for drug administration or sampling; they have the advantages of small wounds, precision, trace volume, and painlessness, and can also improve the accuracy and reliability of biochemical tests. [0003] In recent years, the application of microneedles has mainly focused on transdermal drug delivery, microelectrodes, fluid sampling analysis and detection, etc. At present, the microneedle manufacturing technology mainly adopts silicon micromachining technology and LIGA (Lithographie, Galvanoformung, Abformung, namely photolithography, electroforming and injection molding) and other technologies. The former process generally includes thermal oxidation, photolithography, bulk silicon corrosion, reactive ion etching, etc.; the latter basic steps are X-ray exposure, development, electrop...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): B29C64/124B33Y10/00B33Y80/00
CPCB33Y80/00A61M37/0015A61M2037/0053
Inventor 苟马玲魏于全刘渲
Owner 成都华航创微科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com