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Application of a kind of teriflunomide in preparation of medicine for preventing foot-and-mouth disease virus infection

A technology of foot-and-mouth disease virus and teriflunomide, which is applied in the direction of antiviral agents, nitrile/isonitrile active ingredients, etc., can solve the problems of not being able to provide protection for animals, and achieve the effect of low cytotoxicity

Active Publication Date: 2021-06-08
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, vaccine immunization is the main means of preventing and controlling foot-and-mouth disease. However, there is an "immunity window period" in the use of vaccines, that is, it cannot provide protection to animals within 7 days.

Method used

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  • Application of a kind of teriflunomide in preparation of medicine for preventing foot-and-mouth disease virus infection
  • Application of a kind of teriflunomide in preparation of medicine for preventing foot-and-mouth disease virus infection
  • Application of a kind of teriflunomide in preparation of medicine for preventing foot-and-mouth disease virus infection

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Experimental program
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Effect test

Embodiment 1

[0025] 1. Experimental materials

[0026] 1.1 Cells, Animals, Viruses and Drugs

[0027] IBRS-2 cells were preserved by our research group; 3-day-old suckling mice were purchased from the Experimental Animal Farm of Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences. FMDV (O / MY98 / BY / 2010 and A / GDMM / CHA / 2013) was preserved and provided by the National Foot-and-Mouth Disease Reference Laboratory; Teriflunomide was purchased from MCE and prepared in DMSO.

[0028] 1.2 Reagents

[0029] DMEM, fetal bovine serum FBS, and trypsin medium were purchased from Gibco; MTS detection kit was purchased from Abcam; TRIZOL was purchased from Invitrogen; SYBRPremix Ex Taq Ⅱ The kits were purchased from Bao Biological Engineering (Dalian) Co., Ltd.; RIPA lysate, BCA method protein quantification kit, SDS-PAGE gel preparation kit, ECL were purchased from Biyuntian Company; BSA and PVDF membranes were purchased from BioRad Company; Tween-20 and Tween-80 were purcha...

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Abstract

The invention relates to the application of teriflunomide in the preparation of medicines for preventing foot-and-mouth disease virus infection, and belongs to the technical field of veterinary medicines. The application of the invention can provide a class of highly efficient, safe and quality-controllable anti-foot-and-mouth disease virus medicine for further controlling the spread of foot-and-mouth disease.

Description

technical field [0001] The invention relates to the technical field of veterinary drugs, in particular to the application of teriflunomide in the preparation of drugs for preventing foot-and-mouth disease virus infection. Background technique [0002] Foot-and-mouth disease virus is a non-enveloped single-stranded positive-sense RNA virus belonging to the Picornaviridae family. It has been found that the virus includes 7 serotypes including A, O, C, Asian I, and South African I, II, and III, and each serotype is divided into multiple subtypes. The foot-and-mouth disease caused by this virus mainly infects cloven-hoofed animals such as pigs and cattle, and often forms blisters in the mouth, nose, hooves and other parts, accompanied by clinical symptoms such as fever and walking. Foot-and-mouth disease has many transmission routes, wide epidemic range and strong infectivity. Currently, frequent outbreaks in many countries have seriously threatened the development of global an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/277A61P31/14
Inventor 李世芳常惠芸龚美娇邵军军常艳燕张永光
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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