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Avermectin B2a phosphorylation modifier as well as preparation method and application thereof

A technology of abamectin and phosphorylation, applied in botany equipment and methods, phosphorus organic compounds, applications, etc., can solve problems such as poor application effect of abamectin B2a

Pending Publication Date: 2019-05-17
河北美荷药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problem that the application effect of abamectin B2a is not good at present, the present invention provides a phosphorylated modified substance of abamectin B2a

Method used

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  • Avermectin B2a phosphorylation modifier as well as preparation method and application thereof
  • Avermectin B2a phosphorylation modifier as well as preparation method and application thereof
  • Avermectin B2a phosphorylation modifier as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] This example provides a method for preparing a phosphorylated modified abamectin B2a.

[0028] Specifically include the following steps:

[0029] 10g Abamectin B2a is dissolved in the ethanol (95%v / v) of 100ml, the sodium phosphate of 3.5g is added in the solution, stirring and dissolving, adjust pH value to 8 with 5% sodium hydroxide solution, set solution temperature at 60°C, put the solution into the irradiation platform, and irradiate it with an electron beam (electron beam 10MeV), with an irradiation dose of 1.50kGy. After the irradiation, control the reaction time for 2h, and then evaporate the ethanol on a rotary evaporator , to precipitate the precipitate, filter the precipitate, and dry in a vacuum drying oven at a temperature not exceeding 60°C. Add 30ml of ethanol to the dried solid for recrystallization to obtain the phosphorylated avermectin B2a.

Embodiment 2

[0031] This example provides a method for preparing a phosphorylated modified abamectin B2a.

[0032] Specifically include the following steps:

[0033] 10g Abamectin B2a is dissolved in the ethanol (92%v / v) of 100ml, adds the sodium phosphate of 7g in the solution, stirs and dissolves, adjusts pH value to 6 with 5% sodium hydroxide solution, setting solution temperature is 40°C, put the solution into the irradiation platform, and irradiate it with an electron beam (electron beam 10MeV), with an irradiation dose of 1.00kGy. After the irradiation, control the reaction time for 0.5h, and then evaporate the ethanol on a rotary evaporator , to precipitate the precipitate, filter the precipitate, and dry in a vacuum drying oven at a temperature not exceeding 60°C. Add 30ml of ethanol to the dried solid for recrystallization to obtain the phosphorylated avermectin B2a.

Embodiment 3

[0035] This example provides a method for preparing a phosphorylated modified abamectin B2a.

[0036] Specifically include the following steps:

[0037] 10g Abamectin B2a is dissolved in the ethanol (95%v / v) of 100ml, in the solution, add the sodium phosphate of 3g, stirring and dissolving, adjust pH value to 8 with 5% sodium hydroxide solution, set solution temperature as 60°C, put the solution into the irradiation platform, and irradiate it with an electron beam (electron beam 10MeV), with an irradiation dose of 1.50kGy. After the irradiation, control the reaction time for 1.5h, and then evaporate the ethanol on a rotary evaporator , to precipitate the precipitate, filter the precipitate, and dry in a vacuum drying oven at a temperature not exceeding 60°C. Add 30ml of ethanol to the dried solid for recrystallization to obtain the phosphorylated avermectin B2a.

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PUM

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Abstract

The invention relates to the technical field of agricultural chemicals, in particular to an avermectin B2a phosphorylation modifier as well as a preparation method and application thereof. The structure of the phosphorylation modifier is that hydrogen on all hydroxyl groups in avermectin B2a is replaced by phosphoric acid groups. The preparation method comprises the following steps: preparing avermectin B2a and phosphate into a solution; reacting under electron beam irradiation. The avermectin B2a phosphorylation modifier can be used as a medicament for preventing and controlling root-knot nematode, and can increase the yield of watermelon and improve the quality of the watermelon.

Description

technical field [0001] The invention belongs to the technical field of agricultural chemicals, and in particular relates to a phosphorylated avermectin B2a modified product and its preparation method and application. Background technique [0002] Avermectins and their derivatives belong to biological source insecticides, have bactericidal, insecticidal and acaricidal effects, are safe to humans, animals and the environment, and are widely used in biological pesticides and veterinary drugs. Abamectin is a sixteen-membered macrolide disaccharide compound. Natural abamectin has 8 components in total, and the 8 components are respectively named A1a, A2a, B1a, B2a, A1b, A2b, B1b and B2b, wherein, the drug effect of component B of abamectin is stronger than that of component A, B1 has the highest activity and the widest insecticidal spectrum, followed by B2, but it is the safest for mammals. Abamectin B2 is an accessory in the process of microbial fermentation to produce Abamect...

Claims

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Application Information

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IPC IPC(8): C07F9/09A01N43/90A01P5/00A01P21/00
Inventor 孟凡桥梁妍张梦迪王闪梁剑平
Owner 河北美荷药业有限公司
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