Application of rosmarinic acid in preparation of medicine for inhibiting varicella-zoster virus

A technology of herpes zoster virus and rosmarinic acid, which can be used in antiviral agents, drug combinations, pharmaceutical formulations, etc., and can solve problems such as limitations

Active Publication Date: 2021-11-26
CHENGDU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The wide application of antiviral drugs such as acyclovir and foscarnet sodium has solved the pain of patients, but with the emergence of VZV drug-resistant strains, the application of antiviral drugs such as acyclovir has limitations

Method used

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  • Application of rosmarinic acid in preparation of medicine for inhibiting varicella-zoster virus
  • Application of rosmarinic acid in preparation of medicine for inhibiting varicella-zoster virus
  • Application of rosmarinic acid in preparation of medicine for inhibiting varicella-zoster virus

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Embodiment 1, the research of rosmarinic acid of the present invention to the inhibitory effect of varicella-zoster virus (VZV)

[0021] 1. Experimental method

[0022] In this example, the maintenance solution is composed of 3% calf serum, 1% double antibody and 95% DMEM high-glucose medium, which is prepared and used immediately to maintain the survival of cells without growth.

[0023] 1. Determination of VZV titer

[0024] Inoculate well-growing Vero cells in 96-well cell culture plates at 37°C, 5% CO 2 cultured in an incubator. After the cells adhered to the wall, the VZV stock solution was diluted to 10 with maintenance solution. -1 、10 -2 、10 -3 、10 -4 、10 -5 、10 -6 、10 -7 、10 -8 、10 -9 A total of 9 dilutions were added to each hole of the cell culture plate after discarding the culture medium, and 50 uL of the virus dilution solution of the above concentration was added, and each dilution concentration was provided with 6 duplicate holes, and a cell c...

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Abstract

The invention provides the use of rosmarinic acid in the preparation of medicines for inhibiting varicella-zoster virus. The rosmarinic acid of the present invention has significant inhibitory effect on VZV, can be used to prepare medicines for inhibiting varicella-zoster virus (VZV), and can also be used to prepare medicines for treating infectious diseases caused by varicella-zoster virus, Such diseases include chickenpox and herpes zoster, postherpetic neuralgia, varicella pneumonia, and acute cerebellar ataxia and encephalitis caused by the varicella-zoster virus, among others.

Description

technical field [0001] The invention relates to the use of rosmarinic acid in the preparation of medicines for inhibiting varicella-zoster virus. Background technique [0002] Varicella-zoster virus (VZV) is a double-stranded DNA virus belonging to the subfamily Alphaherpesviridae, which can cause two diseases: varicella and herpes zoster. VZV is highly neurotropic, and can remain latent in the trigeminal nerve and dorsal root ganglia for a long time, and humans are its only host. Under the action of decreased body resistance or some predisposing factors, the latent VZV can be activated and proliferate along the sensory nerve axon to the skin innervated by the nerve, causing herpes zoster. VZV infection is a self-limiting disease in schoolchildren and children; however, in pregnant women, VZV infection can lead to congenital malformations or death in the fetus; in newborns, VZV infection can lead to acute cerebellar ataxia and cerebral In the elderly with low immune functi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/216A61P31/22A61P11/00A61P25/00
Inventor 陈恬李祖锐任科曹康张倩孙宇豪
Owner CHENGDU MEDICAL COLLEGE
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