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Method for improving anticoagulant property of nano particles and application thereof, UV-Ag@TiO2 composite nano particles and medical catheter

A composite nanoparticle, anticoagulant technology, used in anticoagulation treatment, catheters, medical containers, etc., can solve problems such as limited application and poor anticoagulation

Inactive Publication Date: 2019-05-21
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously, the poor anticoagulant property of AgNPs severely limits its application in indwelling blood catheters

Method used

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  • Method for improving anticoagulant property of nano particles and application thereof, UV-Ag@TiO2 composite nano particles and medical catheter
  • Method for improving anticoagulant property of nano particles and application thereof, UV-Ag@TiO2 composite nano particles and medical catheter
  • Method for improving anticoagulant property of nano particles and application thereof, UV-Ag@TiO2 composite nano particles and medical catheter

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Embodiment 1

[0045] The invention provides a method for improving the anticoagulant property of composite nanoparticles, comprising:

[0046] Choose TiO 2 Ag@TiO made from nanoparticles 2 Nanoparticles, using UV light irradiation intensity of 10mW / cm 2 For Ag@TiO with a concentration of 1mg / mL 2 The nanoparticle suspension was irradiated for 60 minutes to obtain UV-Ag@TiO with anticoagulant and antibacterial properties 2 composite nanoparticles.

Embodiment 2

[0048] The invention provides a method for improving the anticoagulant property of composite nanoparticles, comprising:

[0049] Using ultraviolet radiation intensity of 15mW / cm 2 For Ag@TiO with a concentration of 0.1mg / mL 2 The nanoparticle suspension was irradiated for 1 min to obtain UV-Ag@TiO with anticoagulant and antibacterial properties 2 composite nanoparticles.

Embodiment 3

[0051] The invention provides a method for improving the anticoagulant property of composite nanoparticles, comprising:

[0052] The intensity of ultraviolet radiation is 5mW / cm 2 For Ag@TiO with a concentration of 1mg / mL 2 The nanoparticle suspension was irradiated for 60 minutes to obtain UV-Ag@TiO with anticoagulant and antibacterial properties 2 composite nanoparticles.

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Abstract

The invention relates to a method for improving the anticoagulant property of nano particles and application thereof, UV-Ag@TiO2 composite nano particles and a medical catheter, and belongs to the technical field of biological materials. Ultraviolet light is adopted to irradiate the Ag@TiO2 nano particles, and the irradiation time is more than 1 minute. According to the method, the Ag@TiO2 nanoparticles are pretreated through ultraviolet irradiation, so that the photoinduced anticoagulant property of the TiO2 nano particles is transferred to the Ag nano particles, and the anticoagulant property of the Ag nano particles is improved. And by combining the excellent antibacterial capability of the Ag nano particles, the UV-Ag@TiO2 composite nano particles with excellent antibacterial and anti-coagulation capabilities can be obtained. The modification method is simple and economic, and the obtained UV-Ag@TiO2 composite nano particles can be widely applied to surface modification of medicalmaterials with higher requirements on coagulation resistance and antibacterial property, and have remarkable practical value.

Description

technical field [0001] The invention relates to the technical field of biomaterials, and in particular to a method and application for improving anticoagulant properties of nanoparticles, UV-Ag@TiO2 composite nanoparticles and a medical catheter. Background technique [0002] Once the indwelling medical device is infected with bacteria, it will often bring great pain to the patient, as well as a huge economic and social burden. Silver nanoparticles (AgNPs) are the most widely used antibacterial nanomaterials. Due to their large specific surface area, AgNPs can continuously and slowly release Ag+ to react with -SH of bacterial surface enzymes, thus exerting a strong bactericidal effect. Therefore, AgNPs are widely used in the preparation of various antibacterial devices. [0003] But recent studies have pointed out that AgNPs have a significant defect in inducing blood clotting. Therefore, medical devices loaded with AgNPs may have a higher incidence of thrombosis. Obviou...

Claims

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Application Information

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IPC IPC(8): A61L29/10A61L29/16A61L33/02A61L33/00
Inventor 杨苹廖玉珍陈江刘鲁英戴胜黄楠
Owner SOUTHWEST JIAOTONG UNIV